Zobrazeno 1 - 10
of 581
pro vyhledávání: '"cancer heterogeneity"'
Autor:
Jing Wang, He-Kang Ding, Han-Jiang Xu, De-Kai Hu, William Hankey, Li Chen, Jun Xiao, Chao-Zhao Liang, Bing Zhao, Ling-Fan Xu
Publikováno v:
Asian Journal of Andrology, Vol 26, Iss 5, Pp 451-463 (2024)
Tumor metabolic reprogramming is a hallmark of cancer development, and targeting metabolic vulnerabilities has been proven to be an effective approach for castration-resistant prostate cancer (CRPC) treatment. Nevertheless, treatment failure inevitab
Externí odkaz:
https://doaj.org/article/460fbeac57cf4d20964db8f66e364717
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-19 (2024)
Abstract The calcium-binding protein S100A9 has emerged as a pivotal biomolecular actor in oncology, implicated in numerous malignancies. This comprehensive bioinformatics study transcends traditional boundaries, investigating the prognostic and ther
Externí odkaz:
https://doaj.org/article/3ac1f95acf1d4954ad8dd6a74d79c838
Autor:
Nobendu Mukerjee, Swarup Sonar
Publikováno v:
Clinical and Translational Discovery, Vol 4, Iss 4, Pp n/a-n/a (2024)
Abstract Exosomes, small extracellular vesicles secreted by cells, have gained attention as potential therapeutic agents due to their natural ability to deliver biomolecules and traverse biological barriers. However, their limited targeting specifici
Externí odkaz:
https://doaj.org/article/4fbd40f592ec444cb6b86045f49d78f9
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-12 (2024)
Abstract Background Characterizing cancer molecular subtypes is crucial for improving prognosis and individualized treatment. Integrative analysis of multi-omics data has become an important approach for disease subtyping, yielding better understandi
Externí odkaz:
https://doaj.org/article/8e246f60aeea44979f0f15e7dea7e300
Autor:
Jinyuan Xu, Bo Pang, Yujia Lan, Renjie Dou, Shuai Wang, Shaobo Kang, Wanmei Zhang, Yuanyuan Liu, Yijing Zhang, Yanyan Ping
Publikováno v:
Molecular Oncology, Vol 17, Iss 11, Pp 2472-2490 (2023)
High heterogeneity in genome and phenotype of cancer populations made it difficult to apply population‐based common driver genes to the diagnosis and treatment of cancer individuals. Characterizing and identifying the personalized driver mechanism
Externí odkaz:
https://doaj.org/article/6e5f9cf62b4e430c89f015c4e7fc1bdc
Autor:
F Torricelli, B Donati, F Reggiani, V Manicardi, S Piana, R Valli, F Lococo, Alessia Ciarrocchi
Publikováno v:
Molecular Cancer, Vol 22, Iss 1, Pp 1-15 (2023)
Abstract Background Malignant Pleural Mesothelioma (MPM) is a dreadful disease escaping the classical genetic model of cancer evolution and characterized by wide heterogeneity and transcriptional plasticity. Clinical evolution of MPM is marked by a p
Externí odkaz:
https://doaj.org/article/71f3b5ed1c8a49c19f1b0b0ec4911f32
Autor:
Hana Q. Sadida, Alanoud Abdulla, Sara Al Marzooqi, Sheema Hashem, Muzafar A. Macha, Ammira S. Al-Shabeeb Akil, Ajaz A. Bhat
Publikováno v:
Translational Oncology, Vol 39, Iss , Pp 101821- (2024)
Cancer heterogeneity and drug resistance remain pivotal obstacles in effective cancer treatment and management. One major contributor to these challenges is epigenetic modifications - gene regulation that does not involve changes to the DNA sequence
Externí odkaz:
https://doaj.org/article/2bb1b351fffd41b4bdb969179d8d4c17
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
Since the domestication of dogs 10,000 years ago, they have shared their living environment with humans and have co-evolved. The breeding process that dogs have undergone in only a few centuries has led to a significant accumulation of specific genet
Externí odkaz:
https://doaj.org/article/03ceb0d13eff4177bf5c807b29988614
A novel method to identify and characterize personalized functional driver lncRNAs in cancer samples
Autor:
Xuan Zheng, Feng Li, Hongying Zhao, Yongjuan Tang, Ke Xue, Xiaomeng Zhang, Weixin Liang, Rui Zhao, Xingyu Lv, Xinyu Song, Chunlong Zhang, Yanjun Xu, Yunpeng Zhang
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 21, Iss , Pp 2471-2482 (2023)
Cancer is a highly heterogeneous disease, and different individuals of the same cancer type can display different therapeutic effects and prognosis. Genetic variation of long non-coding RNA is the key factor driving tumor development, and plays an im
Externí odkaz:
https://doaj.org/article/6068ba9930054629a761362f9319503c
Publikováno v:
Case Reports in Oncology, Vol 15, Iss 3, Pp 874-880 (2022)
A diagnosis of acute myeloid leukemia involving the central nervous system (CNS) can be confirmed through cerebrospinal fluid (CSF) and serum flow cytometry. These two detection methods should demonstrate the same immunophenotype due to hematogenous
Externí odkaz:
https://doaj.org/article/a4a818e7f80649a58568c4d262bcf911