Zobrazeno 1 - 10
of 829
pro vyhledávání: '"cancer drug resistance"'
Publikováno v:
Cancer Cell International, Vol 24, Iss 1, Pp 1-14 (2024)
Abstract Currently, even the most effective anti-cancer therapies are often limited by the development of drug resistance and tumor relapse, which is a major challenge facing current cancer research. A deep understanding of the molecular and biochemi
Externí odkaz:
https://doaj.org/article/25e4b951c5084cd382a309289391e41d
Publikováno v:
Discover Oncology, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract Purpose This study was designed to investigate the function of RAD51AP1 in the self-renewal and chemosensitivity of CD133 positive (CD133+) ovarian cancer (OC) stem-like cells. Methods CD133+ (CD133 positive) OVCAR4 and CD133 negative (CD133
Externí odkaz:
https://doaj.org/article/d3e993e0977540a3ad3d401a6dd4d1d0
Publikováno v:
Current Issues in Molecular Biology, Vol 46, Iss 6, Pp 5178-5193 (2024)
Histone deacetylase 9 (HDAC9) is known to be upregulated in various cancers. Cancer-associated antigens (CAGEs) are cancer/testis antigens that play an important role in anti-cancer drug resistance. This study aimed to investigate the relationship be
Externí odkaz:
https://doaj.org/article/9dd815432e864cd188e5daf6888066f8
Autor:
Olga A. Sukocheva, Margarita E. Neganova, Yulia Aleksandrova, Jack T. Burcher, Elena Chugunova, Ruitai Fan, Edmund Tse, Gautam Sethi, Anupam Bishayee, Junqi Liu
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-40 (2024)
Abstract Anticancer immune surveillance and immunotherapies trigger activation of cytotoxic cytokine signaling, including tumor necrosis factor-α (TNF-α) and TNF-related apoptosis-inducing ligand (TRAIL) pathways. The pro-inflammatory cytokine TNF-
Externí odkaz:
https://doaj.org/article/3f34fcd20ba7425ab38ab6412822252b
Autor:
Minh Hien Nguyen, Thi Yen Nhi Nguyen, Thien Han Nguyen Le, Thi Ngoc Tam Le, Ngoc Trong Nghia Chau, Tu Manh Huy Le, Bui Quoc Huy Nguyen
Publikováno v:
Heliyon, Vol 10, Iss 20, Pp e39229- (2024)
Despite extensive research in chemotherapy, global cancer concerns persist, exacerbated by the challenge of drug resistance, which imposes economic and medical burdens. Natural compounds, particularly secondary metabolites from medicinal plants, pres
Externí odkaz:
https://doaj.org/article/0ccd57f7dca94ccf82a32b3a19c1ea1c
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Externí odkaz:
https://doaj.org/article/e98cac53f46a45cfbb070e01861b0272
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Epidermal growth factor receptor (EGFR) gene mutations are prevalent in about 50% of lung adenocarcinoma patients. Highly effective tyrosine kinase inhibitors (TKIs) targeting the EGFR protein have revolutionized treatment for the prevalent and aggre
Externí odkaz:
https://doaj.org/article/c55b972464f5461f8a354b404cd3bc39
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 35, Iss 2, Pp 102177- (2024)
Lung cancer remains a significant global health concern with limited treatment options and poor prognosis, particularly in advanced stages. Small extracellular vesicles such as exosomes, secreted by cancer cells, play a pivotal role in mediating drug
Externí odkaz:
https://doaj.org/article/41a117f7c3254b6c8a38732d4c3c077c
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 18, p 9825 (2024)
The tumor-suppressor sphingolipid ceramide is recognized as a key participant in the cytotoxic mechanism of action of many types of chemotherapy drugs, including anthracyclines, Vinca alkaloids, the podophyllotoxin etoposide, taxanes, and the platinu
Externí odkaz:
https://doaj.org/article/4d0c581bb64441318ce014ad4da87a7b
Autor:
Mahesh Koirala, Mario DiPaola
Publikováno v:
Biomedicines, Vol 12, Iss 8, p 1801 (2024)
Resistance to cancer drugs is a complex phenomenon that poses a significant challenge in the treatment of various malignancies. This review comprehensively explores cancer resistance mechanisms and discusses emerging strategies and modalities to over
Externí odkaz:
https://doaj.org/article/5535ea3c7c7d46dab378ce2791594e05