Zobrazeno 1 - 10
of 5 990
pro vyhledávání: '"cancer development"'
Publikováno v:
Discover Oncology, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Copper (Cu) is used as a cofactor in all organisms, and yet it can be toxic at high intracellular concentrations, causing cell death. Diethyldithiocarbamate (DDC) is a Cu ionophore that can transport Cu effectively into the cell. Copper-diet
Externí odkaz:
https://doaj.org/article/0c5fe8a60e204cda86d41b97315b43b0
Publikováno v:
Discover Oncology, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Prostate cancer (PCa) is a commonly occurring malignancy in elderly men. Olaparib, a poly ADP-ribose polymerase inhibitor, is utilized in PCa treatment. However, patients often develop resistance to olaparib after a period of treatment. Gene
Externí odkaz:
https://doaj.org/article/7f615adb8c2a44f29c8a4b128e6aebd9
Autor:
Zixu Zhang, David Westover, Zhantong Tang, Yue Liu, Jinghan Sun, Yunxi Sun, Runqing Zhang, Xingyue Wang, Shihui Zhou, Nigaerayi Hesilaiti, Qi Xia, Zhenfang Du
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-26 (2024)
Abstract Wnt/β-catenin signaling is a critical pathway that influences development and therapeutic response of non-small cell lung cancer (NSCLC). In recent years, many Wnt regulators, including proteins, miRNAs, lncRNAs, and circRNAs, have been fou
Externí odkaz:
https://doaj.org/article/4ed9d1047bf4444f8b031273f0e24e68
Publikováno v:
Discover Oncology, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Castration-resistant prostate cancer (CRPC) represents the final stage of prostate cancer (PCa). Cabazitaxel, a taxane chemotherapy drug, is used in treating CRPC. However, patients with CRPC eventually develop resistance to cabazitaxel, and
Externí odkaz:
https://doaj.org/article/7d1117980af84257be763aff6bbcbcf5
Autor:
Shanika Karunasagara, Ali Taghizadeh, Sang‐Hyun Kim, So Jung Kim, Yong‐Jae Kim, Mohsen Taghizadeh, Moon‐Young Kim, Kyu‐Young Oh, Jung‐Hwan Lee, Hye Sung Kim, Jeongeun Hyun, Hae‐Won Kim
Publikováno v:
Advanced Science, Vol 11, Iss 35, Pp n/a-n/a (2024)
Abstract Epithelial‐stromal interplay through chemomechanical cues from cells and matrix propels cancer progression. Elevated tissue stiffness in potentially malignant tissues suggests a link between matrix stiffness and enhanced tumor growth. In t
Externí odkaz:
https://doaj.org/article/5d9ed89cb8184bc5be14e2bdcc15a4b7
Publikováno v:
Genes and Diseases, Vol 11, Iss 2, Pp 861-873 (2024)
Microrchidia CW-type zinc finger 2 (MORC2) is a member of the MORC superfamily of nuclear proteins. Growing evidence has shown that MORC2 not only participates in gene transcription and chromatin remodeling but also plays a key in human disease and t
Externí odkaz:
https://doaj.org/article/e812af5fab914708a319705b5982587d
Publikováno v:
Gut Microbes, Vol 16, Iss 1 (2024)
ABSTRACTThe role of gut fungal species in tumor-related processes remains largely unexplored, with most studies still focusing on fungal infections. This review examines the accumulating evidence suggesting the involvement of commensal and pathogenic
Externí odkaz:
https://doaj.org/article/c79f604e8a7d4c9091e1b27b2bd7051f
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Notch signaling pathway is a highly conserved system of cell-to-cell communication that participates in various biological processes, such as stem cell maintenance, cell fate decision, cell proliferation and death during homeostasis and development.
Externí odkaz:
https://doaj.org/article/47a4925fdee140f0885ef4a2b142a0c8
Autor:
Ryo Takasaki, Fumihiko Uchida, Shohei Takaoka, Ryota Ishii, Satoshi Fukuzawa, Eiji Warabi, Naomi Ishibashi-Kanno, Kenji Yamagata, Hiroki Bukawa, Toru Yanagawa
Publikováno v:
Current Issues in Molecular Biology, Vol 45, Iss 9, Pp 7630-7641 (2023)
To determine the intracellular behavior of p62, a marker of selective autophagy, in oral potentially malignant disorders (OPMDs). This retrospective study includes 70 patients who underwent biopsy or surgical resection and were definitively diagnosed
Externí odkaz:
https://doaj.org/article/c0e1533cb1ad4318bfce7d306158cfef
Publikováno v:
Open Medicine, Vol 18, Iss 1, Pp 7-33 (2023)
Copper can be toxic at very high intracellular concentrations and can inhibit prostate cancer (PCa) progression. Recently, a study reported the mechanism of cuproptosis and the potentially associated genes. However, the function of these cuproptosis-
Externí odkaz:
https://doaj.org/article/b07944a008a6458d8614fa9aae477a1b