Zobrazeno 1 - 10
of 836
pro vyhledávání: '"calcium sparks"'
Publikováno v:
Biomolecules, Vol 14, Iss 11, p 1371 (2024)
Previous studies have observed alterations in excitation–contraction (EC) coupling during end-stage heart failure that include action potential and calcium (Ca2+) transient prolongation and a reduction of the Ca2+ transient amplitude. Underlying th
Externí odkaz:
https://doaj.org/article/06a1d2fc0b2b40e39addabbf52512765
Akademický článek
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Publikováno v:
Biomolecules, Vol 13, Iss 8, p 1259 (2023)
Calcium (Ca2+) sparks are the elementary events of excitation–contraction coupling, yet they are not explicitly represented in human ventricular myocyte models. A stochastic ventricular cardiomyocyte human model that adapts to intracellular Ca2+ ([
Externí odkaz:
https://doaj.org/article/ab0704475f0241f6996558e6c961f2bf
Autor:
Xin Shen, Jonas van den Brink, Anna Bergan-Dahl, Terje R Kolstad, Einar S Norden, Yufeng Hou, Martin Laasmaa, Yuriana Aguilar-Sanchez, Ann P Quick, Emil KS Espe, Ivar Sjaastad, Xander HT Wehrens, Andrew G Edwards, Christian Soeller, William E Louch
Publikováno v:
eLife, Vol 11 (2022)
Ryanodine receptors (RyRs) exhibit dynamic arrangements in cardiomyocytes, and we previously showed that ‘dispersion’ of RyR clusters disrupts Ca2+ homeostasis during heart failure (HF) (Kolstad et al., eLife, 2018). Here, we investigated whether
Externí odkaz:
https://doaj.org/article/8009cf35beb44a249e475603ed937272
Autor:
Rogelio Salazar-Enciso, Agustín Guerrero-Hernández, Ana M. Gómez, Jean-Pierre Benitah, Angélica Rueda
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
In mesenteric arteries (MAs), aldosterone (ALDO) binds to the endogenous mineralocorticoid receptor (MR) and increases the expression of the voltage-gated L-type Cav1.2 channel, an essential ion channel for vascular contraction, sarcoplasmic reticulu
Externí odkaz:
https://doaj.org/article/653addf7fc8e4380b8526cd6db8e7914
Autor:
Casey Reid, Monica Romero, Stephanie B. Chang, Noah Osman, Jose L. Puglisi, Christopher G. Wilson, Arlin B. Blood, Lubo Zhang, Sean M. Wilson
Publikováno v:
Frontiers in Physiology, Vol 12 (2022)
Cerebral arterial vasoreactivity is vital to the regulation of cerebral blood flow. Depolarization of arterial myocytes elicits whole-cell Ca2+ oscillations as well as subcellular Ca2+ sparks due to activation of ryanodine receptors on the sarcoplasm
Externí odkaz:
https://doaj.org/article/ca2f1c78ab6c417ca7961d33da443583
Autor:
Jianxin Deng, Xiangsheng Cai, Mingyu Hao, Xueting Liu, Zelong Chen, Haiyan Li, Junying Liu, Yunxiu Liao, Hao Fu, Huiyan Chen, Gangjian Qin, Dewen Yan
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 8 (2021)
Calcium dobesilate (CaD) is used effectively in patients with diabetic microvascular disorder, retinopathy, and nephropathy. Here we sought to determine whether it has an effect on cardiomyocytes calcium mishandling that is characteristic of diabetic
Externí odkaz:
https://doaj.org/article/6b34c0b4316c48d79afeac324affc431
Publikováno v:
Biomolecules, Vol 12, Iss 8, p 1030 (2022)
The ryanodine receptor (RyR2) has a critical role in controlling Ca2+ release from the sarcoplasmic reticulum (SR) throughout the cardiac cycle. RyR2 protein has multiple functional domains with specific roles, and four of these RyR2 protomers are re
Externí odkaz:
https://doaj.org/article/5d32932f269b45ba99b47a43c7e980f9
Akademický článek
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Autor:
Gaudencio Fernández-Miranda, Tatiana Romero-Garcia, Tarín P. Barrera-Lechuga, Martha Mercado-Morales, Angélica Rueda
Publikováno v:
Frontiers in Physiology, Vol 10 (2019)
Metabolic syndrome (MetS) has become a global epidemic. MetS is a serious health problem because of its related cardiovascular complications, which include hypertension and delayed heart rate recovery after exercise. The molecular bases of cardiac dy
Externí odkaz:
https://doaj.org/article/26b59160a24e4203ae0fe5c1a0483a68