Zobrazeno 1 - 10
of 1 107
pro vyhledávání: '"cGAS–STING pathway"'
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-18 (2024)
Abstract Background Polycystic ovary syndrome (PCOS) is the most common cause of anovulatory infertility. The ketogenic diet (KD), a diet high in fat and low in carbohydrates, has been applied clinically for the treatment of obese women with PCOS. We
Externí odkaz:
https://doaj.org/article/dbbbedcbd5594e7990d4fcfedc3a62c5
Autor:
Thurid Lauf, Antje Häder, Franziska Hornung, Yasmina Reisser, Sandor Nietzsche, Fabian Schanz, Verena Trümper, Aldona Jeznach, Sascha Brunke, Torsten Doenst, Tomasz Skirecki, Bettina Löffler, Stefanie Deinhardt-Emmer
Publikováno v:
Immunity & Ageing, Vol 21, Iss 1, Pp 1-15 (2024)
Abstract Ageing is a major risk factor that contributes to increased mortality and morbidity rates during influenza A virus (IAV) infections. Macrophages are crucial players in the defense against viral infections and display impaired function during
Externí odkaz:
https://doaj.org/article/a53e4bc03a7c4494b52dfbb0481c6c0d
Publikováno v:
International Journal of Nanomedicine, Vol Volume 19, Pp 10685-10697 (2024)
Ana RS Ribeiro,1,2 Theresa Neuper,1– 3 Jutta Horejs-Hoeck1– 3 1Department of Biosciences and Medical Biology, Paris Lodron University of Salzburg, Salzburg, Austria; 2Cancer Cluster Salzburg (CCS), Salzburg, 5020, Austria; 3Center for Tumor biolo
Externí odkaz:
https://doaj.org/article/8d5fb812996c48ae95a5e5f47c27d6ed
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
The cGAS-STING signaling pathway is a critical component of the innate immune response, playing a significant role in various diseases. As a central element of this pathway, STING responds to both endogenous and exogenous DNA stimuli, triggering the
Externí odkaz:
https://doaj.org/article/c7cae8e8df0e4bb6876110b5dfb71e4e
Autor:
Xiaodian Zhang, Hailong Tian, Yang Chen, Baichuan Liang, Edouard C. Nice, Canhua Huang, Na Xie, Shaojiang Zheng
Publikováno v:
Journal of Nanobiotechnology, Vol 22, Iss 1, Pp 1-20 (2024)
Abstract Immunotherapy has shown marked progress in promoting systemic anti-colorectal cancer (CRC) clinical effects. For further effectively sensitizing CRC to immunotherapy, we have engineered a pH-sensitive zeolitic imidazolate framework-8 (CS/NPs
Externí odkaz:
https://doaj.org/article/c680ef09da4d46f4a74a0ba001838a51
Publikováno v:
陆军军医大学学报, Vol 46, Iss 18, Pp 2036-2045 (2024)
Objective To investigate the role and possible mechanisms of transactive response DNA binding protein 43 (TDP-43) in mediating neuronal injury induced by oxidative stress in mouse neuro-2a (N2a) cells and mouse pain sensitization. Methods ① To eval
Externí odkaz:
https://doaj.org/article/95c278bf944f49f58106a8c7ea2e5a18
Autor:
Congyang Zheng, Yuanyuan Chen, Tingting He, Ye Xiu, Xu Dong, Xianling Wang, Xinru Wen, Chengwei Li, Qing Yao, Simin Chen, Xiaoyan Zhan, Lili Gao, Zhaofang Bai
Publikováno v:
Molecular Medicine, Vol 30, Iss 1, Pp 1-16 (2024)
Abstract Background The cGAS-STING pathway is an important component of the innate immune system and plays significant role in acetaminophen-induced liver injury (AILI). Pentagalloylglucose (PGG) is a natural polyphenolic compound with various benefi
Externí odkaz:
https://doaj.org/article/3ebf47e73fe04a2aa173360846226518
Autor:
Xiayi Liang, Duo Wang, Yuanquan Zhao, Xiaobo Wang, Siyang Yao, Wei Huang, Yongyu Yang, Xiaofeng Dong, Lei Zhang, Jianrong Yang
Publikováno v:
Journal of Nanobiotechnology, Vol 22, Iss 1, Pp 1-15 (2024)
Abstract Background Manganese ions (Mn2+) combined with adjuvants capable of damaging and lysing tumor cells form an antitumor nano-modulator that enhances the immune efficacy of cancer therapy through the cascade activation of the cyclic GMP-AMP int
Externí odkaz:
https://doaj.org/article/4c5d647fc6004d3ebabcbf1f7e986d0e
Autor:
An Shao, Lulu Jin, Yanni Ge, Ziqiang Ye, Mingyu Xu, Yifan Zhou, Yingyu Li, Linyan Wang, Pinglong Xu, Kai Jin, Zhengwei Mao, Juan Ye
Publikováno v:
Bioactive Materials, Vol 39, Iss , Pp 392-405 (2024)
Retinal neovascularization (RNV), a typical pathological manifestation involved in most neovascular diseases, causes retinal detachment, vision loss, and ultimately irreversible blindness. Repeated intravitreal injections of anti-VEGF drugs were deve
Externí odkaz:
https://doaj.org/article/45b5147555d34f59bc7d8743357b48d0
Publikováno v:
Experimental Hematology & Oncology, Vol 13, Iss 1, Pp 1-19 (2024)
Abstract Background Radiotherapy can modulate systemic antitumor immunity, while immune status in the tumor microenvironment also influences the efficacy of radiotherapy, but relevant molecular mechanisms are poorly understood in lung adenocarcinoma
Externí odkaz:
https://doaj.org/article/6bcfd859e16b49e493bba7b10b243443