Zobrazeno 1 - 10
of 3 028
pro vyhledávání: '"cGAS/STING"'
Autor:
Kyoung-Seok Oh, Ah-Rong Nam, Ju-Hee Bang, Yoojin Jeong, Sea Young Choo, Hyo Jung Kim, Su In Lee, Jae-Min Kim, Jeesun Yoon, Tae-Yong Kim, Do-Youn Oh
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-16 (2024)
Abstract Although the efficacy of trastuzumab deruxtecan (T-DXd) against HER2-positive gastric cancers (GCs) has driven its clinical application, the precise mechanisms governing its immunomodulatory role remain unclear. In this study, we examined th
Externí odkaz:
https://doaj.org/article/fda6107846d1415994d39964ffe7e727
Publikováno v:
International Journal of Nanomedicine, Vol Volume 19, Pp 10685-10697 (2024)
Ana RS Ribeiro,1,2 Theresa Neuper,1– 3 Jutta Horejs-Hoeck1– 3 1Department of Biosciences and Medical Biology, Paris Lodron University of Salzburg, Salzburg, Austria; 2Cancer Cluster Salzburg (CCS), Salzburg, 5020, Austria; 3Center for Tumor biolo
Externí odkaz:
https://doaj.org/article/8d5fb812996c48ae95a5e5f47c27d6ed
Publikováno v:
BMC Cancer, Vol 24, Iss 1, Pp 1-13 (2024)
Abstract The innate immune system is the first responder to infectious agents, cellular debris, and cancerous growths. This system plays critical roles in the antitumor immune responses by boosting and priming T cell-mediated cytotoxicity but is unde
Externí odkaz:
https://doaj.org/article/a0372b953f7d4b58bb992040a81e4e79
Autor:
Xiaodian Zhang, Hailong Tian, Yang Chen, Baichuan Liang, Edouard C. Nice, Canhua Huang, Na Xie, Shaojiang Zheng
Publikováno v:
Journal of Nanobiotechnology, Vol 22, Iss 1, Pp 1-20 (2024)
Abstract Immunotherapy has shown marked progress in promoting systemic anti-colorectal cancer (CRC) clinical effects. For further effectively sensitizing CRC to immunotherapy, we have engineered a pH-sensitive zeolitic imidazolate framework-8 (CS/NPs
Externí odkaz:
https://doaj.org/article/c680ef09da4d46f4a74a0ba001838a51
Publikováno v:
Machine Learning and Knowledge Extraction, Vol 6, Iss 3, Pp 2033-2048 (2024)
The study presented in this paper evaluated gene expression profiles from The Cancer Genome Atlas (TCGA). To reduce complexity, we focused on genes in the cGAS–STING pathway, crucial for cytosolic DNA detection and immune response. The study analyz
Externí odkaz:
https://doaj.org/article/3f827c73e1ee49de999dc93625291b3f
Publikováno v:
陆军军医大学学报, Vol 46, Iss 18, Pp 2036-2045 (2024)
Objective To investigate the role and possible mechanisms of transactive response DNA binding protein 43 (TDP-43) in mediating neuronal injury induced by oxidative stress in mouse neuro-2a (N2a) cells and mouse pain sensitization. Methods ① To eval
Externí odkaz:
https://doaj.org/article/95c278bf944f49f58106a8c7ea2e5a18
Autor:
Jong Hoon Lee, Consolato Sergi, Richard E. Kast, Badar A. Kanwar, Jean Bourbeau, Sangsuk Oh, Mun-Gi Sohn, Chul Joong Lee, Michael D. Coleman
Publikováno v:
Virology Journal, Vol 21, Iss 1, Pp 1-15 (2024)
Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) induces immune-mediated diseases. The pathophysiology of COVID-19 uses the following three mechanisms: (1) inflammasome activation mechanism; (2) cGAS–STING signaling mechanism;
Externí odkaz:
https://doaj.org/article/499a6cd62daa4ec48434023b2df37b92
Autor:
Congyang Zheng, Yuanyuan Chen, Tingting He, Ye Xiu, Xu Dong, Xianling Wang, Xinru Wen, Chengwei Li, Qing Yao, Simin Chen, Xiaoyan Zhan, Lili Gao, Zhaofang Bai
Publikováno v:
Molecular Medicine, Vol 30, Iss 1, Pp 1-16 (2024)
Abstract Background The cGAS-STING pathway is an important component of the innate immune system and plays significant role in acetaminophen-induced liver injury (AILI). Pentagalloylglucose (PGG) is a natural polyphenolic compound with various benefi
Externí odkaz:
https://doaj.org/article/3ebf47e73fe04a2aa173360846226518
Autor:
Xianglin Peng, Feifei Pu, Fangzheng Zhou, Xiyong Dai, Feng Xu, Junwen Wang, Jing Feng, Ping Xia
Publikováno v:
BMC Infectious Diseases, Vol 24, Iss 1, Pp 1-10 (2024)
Abstract Background This study aimed to investigate the differential expression levels of the cGAS-STING pathway in peripheral blood mononuclear cells (PBMCs) of spinal tuberculosis (TB) patients with different progression and its feasibility as a di
Externí odkaz:
https://doaj.org/article/b447c7a760a84d56af77c129d5fb236f
Autor:
Xiayi Liang, Duo Wang, Yuanquan Zhao, Xiaobo Wang, Siyang Yao, Wei Huang, Yongyu Yang, Xiaofeng Dong, Lei Zhang, Jianrong Yang
Publikováno v:
Journal of Nanobiotechnology, Vol 22, Iss 1, Pp 1-15 (2024)
Abstract Background Manganese ions (Mn2+) combined with adjuvants capable of damaging and lysing tumor cells form an antitumor nano-modulator that enhances the immune efficacy of cancer therapy through the cascade activation of the cyclic GMP-AMP int
Externí odkaz:
https://doaj.org/article/4c5d647fc6004d3ebabcbf1f7e986d0e