Dichloroacetate reduces cisplatin-induced apoptosis by inhibiting the JNK/14-3-3/Bax/caspase-9 pathway and suppressing caspase-8 activation via cFLIP in murine tubular cells

Autor: Hideki Kimura, Kazuko Kamiyama, Toru Imamoto, Izumi Takeda, Mamiko Kobayashi, Naoki Takahashi, Kenji Kasuno, Takeshi Sugaya, Masayuki Iwano

Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-19 (2024)

Abstract Cisplatin-induced injury to renal proximal tubular cells stems from mitochondrial damage-induced apoptosis and inflammation. Dichloroacetate (DCA), a pyruvate dehydrogenase kinase (PDK) inhibitor, a potential generator of ROS and ATP, protec

Externí odkaz: https://doaj.org/article/b817c57363ca4a61a060f910d74cccee

cFLIP in the molecular regulation of astroglia-driven neuroinflammation in experimental glaucoma

Autor: Xiangjun Yang, Qun Zeng, Maide Gözde İnam, Onur İnam, Chyuan-Sheng Lin, Gülgün Tezel

Publikováno v: Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-19 (2024)

Abstract Background Recent experimental studies of neuroinflammation in glaucoma pointed to cFLIP as a molecular switch for cell fate decisions, mainly regulating cell type-specific caspase-8 functions in cell death and inflammation. This study aimed

Externí odkaz: https://doaj.org/article/898c58d6393d4678b4a15463d1028d07

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HuR inhibition overcomes cFLIP-mediated doxorubicin resistance in triple-negative breast cancer.

Autor: Wei L; Bioengineering Program, The University of Kansas, Lawrence, KS, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Kim SH; Department of Molecular Biosciences, The University of Kansas, Lawrence, KS, USA., Armaly AM; Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, The University of North Carolina, Chapel Hill, NC, USA., Aubé J; Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, The University of North Carolina, Chapel Hill, NC, USA., Xu L; Department of Molecular Biosciences, The University of Kansas, Lawrence, KS, USA. xul@ku.edu.; The University of Kansas Cancer Center, The University of Kansas Medical Center, Kansas City, KS, USA. xul@ku.edu.; Department of Radiation Oncology, The University of Kansas Medical Center, Kansas City, KS, USA. xul@ku.edu., Wu X; Department of Molecular Biosciences, The University of Kansas, Lawrence, KS, USA. wuxq@ku.edu.; The University of Kansas Cancer Center, The University of Kansas Medical Center, Kansas City, KS, USA. wuxq@ku.edu.

Publikováno v: NPJ precision oncology [NPJ Precis Oncol] 2024 Dec 20; Vol. 8 (1), pp. 286. Date of Electronic Publication: 2024 Dec 20.

Triple Silencing of HSP27, cFLIP, and CLU Genes Promotes the Sensitivity of Doxazosin-Induced Apoptosis in PC-3 Prostate Cancer Cells

Autor: Jeong Man Cho, Sojung Sun, Eunji Im, Hyunwon Yang, Tag Keun Yoo

Publikováno v: Medicines, Vol 11, Iss 3, p 7 (2024)

Background: This study investigated how the expression of heat shock protein 27 (HSP27), cellular FLICE-like inhibitory protein (cFLIP), and clusterin (CLU) affects the progression of cancer cells and their susceptibility to doxazosin-induced apoptos

Externí odkaz: https://doaj.org/article/63de43ba634147849449aaf4c3fd881c