Plasticity and therapeutic potential of cAMP and cGMP-specific phosphodiesterases in Toxoplasma gondii

Autor: Kim Chi Vo, Liberta Ruga, Olympia Ekaterini Psathaki, Rico Franzkoch, Ute Distler, Stefan Tenzer, Michael Hensel, Peter Hegemann, Nishith Gupta

Publikováno v: Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 5775-5789 (2022)

Toxoplasma gondii is a common zoonotic protozoan pathogen adapted to intracellular parasitism in many host cells of diverse organisms. Our previous work has identified 18 cyclic nucleotide phosphodiesterase (PDE) proteins encoded by the parasite geno

Externí odkaz: https://doaj.org/article/b52377f7bb7749cbacfacb575705260f

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The visinin-like proteins VILIP-1 and VILIP-3 in Alzheimer's disease—old wine in new bottles

Autor: Karl-Heinz Braunewell

Publikováno v: Frontiers in Molecular Neuroscience, Vol 5 (2012)
Frontiers in Molecular Neuroscience

The neuronal Ca(2+)-sensor (NCS) proteins VILIP-1 and VILIP-3 have been implicated in the etiology of Alzheimer's disease (AD). Genome-wide association studies (GWAS) show association of genetic variants of VILIP-1 (VSNL1) and VILIP-3 (HPCAL1) with A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::291f4ac805b435ba2da9829675699af1

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In vivo blockade of α1-adrenergic receptors mitigates stress-disturbed cAMP and cGMP signaling in Leydig cells.

Autor: Stojkov NJ; Reproductive Endocrinology and Signaling Group, Department of Biology and Ecology, Faculty of Sciences, University of Novi Sad, Dositeja Obradovica Square 2, Novi Sad 21000, Serbia., Baburski AZ, Bjelic MM, Sokanovic SJ, Mihajlovic AI, Drljaca DM, Janjic MM, Kostic TS, Andric SA

Publikováno v: Molecular human reproduction [Mol Hum Reprod] 2014 Jan; Vol. 20 (1), pp. 77-88. Date of Electronic Publication: 2013 Jul 26.