Skin cancer biology and barriers to treatment: Recent applications of polymeric micro/nanostructures

Autor: Xin-Ying Ji, Muhammad Farhan Khan, Asim Ur Rehman, Mahnoor Baloch, Lei Qian, Dongdong Wu, Ebenezeri Erasto Ngowi, Nazeer Hussain Khan, Maria Mir

Publikováno v: Journal of Advanced Research, Vol 36, Iss, Pp 223-247 (2022)
Journal of Advanced Research

Graphical abstract
Highlights • Skin cancer is a fatal public health concern rising continuously all over the world. • Several environmental and genetic risk factors are associated with cutaneous carcinogenesis. • Use of nanocarriers for t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4504efcb0df22ab6d14aa8271e9a2d16
https://doi.org/10.1016/j.jare.2021.06.014

Key reaction components affect the kinetics and performance robustness of cell-free protein synthesis reactions

Autor: Alice M. Banks, Colette J. Whitfield, Steven R. Brown, David A. Fulton, Sarah A. Goodchild, Christopher Grant, John Love, Dennis W. Lendrem, Jonathan E. Fieldsend, Thomas P. Howard

Publikováno v: Computational and Structural Biotechnology Journal, Vol 20, Iss, Pp 218-229 (2022)
Computational and Structural Biotechnology Journal

Graphical abstract
Highlights • Novel cell-free protein synthesis reaction buffer improves performance by 400%. • Enhanced performance is maintained across the synthesis of different proteins. • Protein synthesis performance is robust acro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75d8a1b131f6dc02f2654a6fd7aef7a7
http://www.sciencedirect.com/science/article/pii/S2001037021005213

Clinical efficacies, underlying mechanisms and molecular targets of Chinese medicines for diabetic nephropathy treatment and management

Autor: Hai-Yong Chen, Yibin Feng, Cheng Zhang, Ning Wang, Sha Li, Guoyi Tang

Publikováno v: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 9, Pp 2749-2767 (2021)

Diabetic nephropathy (DN) has been recognized as a severe complication of diabetes mellitus and a dominant pathogeny of end-stage kidney disease, which causes serious health problems and great financial burden to human society worldwide. Conventional

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68d8ab4193adc39b242fa3c089b4f517
https://doi.org/10.1016/j.apsb.2020.12.020

Fasting Hormones Synergistically Induce Amino Acid Catabolism Genes to Promote Gluconeogenesis

Autor: Maya Finkel, Nufar Buchshtab, Meirav Bar-Shimon, Noga Korenfeld, Ido Goldstein, Meital Charni-Natan

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 3, Pp 1021-1036 (2021)
Cellular and Molecular Gastroenterology and Hepatology

Background & Aims Gluconeogenesis from amino acids (AAs) maintains glucose homeostasis during fasting. Although glucagon is known to regulate AA catabolism, the contribution of other hormones to it and the scope of transcriptional regulation dictatin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ae2cd9101a9b091bf3a2c1fa8f4cfbf
https://doi.org/10.1016/j.jcmgh.2021.04.017

Role of calcineurin biosignaling in cell secretion and the possible regulatory mechanisms

Autor: Saeedah Hamdan Al-Jadani, Saad Saeed Alamri, Hani Alothaid, Jehan S. Alrahimi, Mohammed S. Aldughaim

Publikováno v: Saudi Journal of Biological Sciences
Saudi Journal of Biological Sciences, Vol 28, Iss 1, Pp 116-124 (2021)

Cyclic adenosine monophosphate (cAMP) and calcium ions (Ca2+) are two chemical molecules that play a central role in the stimulus-dependent secretion processes within cells. Ca2+ acts as the basal signaling molecule responsible to initiate cell secre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73bd077992989fe7b70db57b5b7a848a
http://europepmc.org/articles/PMC7783665