1,3-Dichloroadamantyl-Containing Ureas as Potential Triple Inhibitors of Soluble Epoxide Hydrolase, p38 MAPK and c-Raf.

Autor: Gladkikh, Boris P.¹ (AUTHOR) gladkih-boris@mail.ru, Danilov, Dmitry V.¹ (AUTHOR) danilov.dmitry.vlz@yandex.ru, D'yachenko, Vladimir S.^1,2 (AUTHOR) gmbutov@mail.ru, Butov, Gennady M.^1,2 (AUTHOR)

Publikováno v: International Journal of Molecular Sciences. Jan2024, Vol. 25 Issue 1, p338. 29p.

Exploiting c-RAF dependency in RAS mutant cancer: beyond catalytic activity.

Autor: Cooke, Sean F., Blair, Connor M.

Publikováno v: Expert Review of Anticancer Therapy; Mar/Apr2024, Vol. 24 Issue 3/4, p95-100, 6p

Disruption of the pro-oncogenic c-RAF–PDE8A complex represents a differentiated approach to treating KRAS–c-RAF dependent PDAC

Autor: Sean F. Cooke, Thomas A. Wright, Yuan Yan Sin, Jiayue Ling, Elka Kyurkchieva, Nattaporn Phanthaphol, Thomas Mcskimming, Katharine Herbert, Selma Rebus, Andrew V. Biankin, David K. Chang, George S. Baillie, Connor M. Blair

Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)

Abstract Pancreatic ductal adenocarcinoma (PDAC) is considered the third leading cause of cancer mortality in the western world, offering advanced stage patients with few viable treatment options. Consequently, there remains an urgent unmet need to d

Externí odkaz: https://doaj.org/article/16d4a69d0ef14307a98c84f3b800fbc9

Oxidative protein damage negatively affects protein-protein interaction: The case of KRAS-cRAF.

Autor: Rudan Dimlić M; Mediterranean Institute for Life Sciences, Split, Croatia. Electronic address: marina.rudandimlic@medils.hr., Raić S; Mediterranean Institute for Life Sciences, Split, Croatia., Močibob M; Department of Chemistry, Faculty of Science, University of Zagreb, Zagreb, Croatia., Sanader Maršić Ž; Department of Physics, Faculty of Science, University of Split, Split, Croatia., Yao Z; Donnelly Centre, University of Toronto, Temerty School of Medicine, Ontario, Canada., Radman M; Mediterranean Institute for Life Sciences, Split, Croatia., Stagljar I; Mediterranean Institute for Life Sciences, Split, Croatia; Donnelly Centre, University of Toronto, Temerty School of Medicine, Ontario, Canada; Department of Molecular Genetics, University of Toronto, Ontario, Canada; Department of Biochemistry, University of Toronto, Ontario, Canada; School of Medicine, University of Split, Croatia. Electronic address: igor.stagljar@utoronto.ca.

Publikováno v: Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2024 Nov 19; Vol. 734, pp. 150792. Date of Electronic Publication: 2024 Oct 03.

Arabidopsis group C Raf-like protein kinases negatively regulate abscisic acid signaling and are direct substrates of SnRK2

Autor: Kamiyama, Yoshiaki, Hirotani, Misaki, Ishikawa, Shinnosuke, Minegishi, Fuko, Katagiri, Sotaro, Rogan, Conner J., Takahashi, Fuminori, Nomoto, Mika, Ishikawa, Kazuya, Kodama, Yutaka, Tada, Yasuomi, Takezawa, Daisuke, Anderson, Jeffrey C., Peck, Scott C., Shinozaki, Kazuo, Umezawa, Taishi

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, 2021 Jul . 118(30), 1-9.

Externí odkaz: https://www.jstor.org/stable/27052654