Transcriptome Profile Identifies Actin as an Essential Regulator of Cardiac Myosin Binding Protein C3 Hypertrophic Cardiomyopathy in a Zebrafish Model

Autor: Sahar Isa Da’as, Waseem Hasan, Rola Salem, Nadine Younes, Doua Abdelrahman, Iman A. Mohamed, Arwa Aldaalis, Ramzi Temanni, Lisa Sara Mathew, Stephan Lorenz, Magdi Yacoub, Michail Nomikos, Gheyath K. Nasrallah, Khalid A. Fakhro

Publikováno v: International Journal of Molecular Sciences; Volume 23; Issue 16; Pages: 8840

Variants in cardiac myosin-binding protein C (cMyBP-C) are the leading cause of inherited hypertrophic cardiomyopathy (HCM), demonstrating the key role that cMyBP-C plays in the heart’s contractile machinery. To investigate the c-MYBPC3 HCM-related

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52f8469169f445c5aac84e954b5e6548

Human c-MYBPC3 RNA Targeted Therapy, Reversal of Hypertrophic Cardiomyopathy in the Zebrafish Model

Autor: Sahar I. Da'as, Magdi H. Yacoub, Huseyin C. Yalcin, Jasim Al Suwaidi, Gheyath K. Nasrallah, Iman A. Mohammed

Hypertrophic cardiomyopathy (HCM) is a serious heart disease and is defined as abnormal left ventricular (LV) wall thickening with diastolic dysfunction. HCM is an autosomal dominant monogenic disease caused by a mutation in 1 of 13 or more genes enc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::395dcd8a79705524403bb4f90531b6c9
http://www.qscience.com/doi/pdfplus/10.5339/qfarc.2016.HBPP2955

Hypertrophic cardiomyopathy-linked variants of cardiac myosin-binding protein C3 display altered molecular properties and actin interaction.

Autor: Da'as SI; Translational Medicine, Sidra Medicine, Doha, Qatar.; College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar., Fakhro K; Translational Medicine, Sidra Medicine, Doha, Qatar.; College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar.; Weill Cornell Medical College, Doha, Qatar., Thanassoulas A; National Center for Scientific Research 'Demokritos', Aghia Paraskevi, Greece., Krishnamoorthy N; Translational Medicine, Sidra Medicine, Doha, Qatar.; Heart Science Centre, National Heart and Lung Institute, Imperial College, London, U.K., Saleh A; College of Medicine, Member of QU Health, Qatar University, Doha, Qatar., Calver BL; College of Biomedical & Life Sciences, Cardiff University, Cardiff, U.K., Safieh-Garabedian B; College of Medicine, Member of QU Health, Qatar University, Doha, Qatar., Toft E; College of Medicine, Member of QU Health, Qatar University, Doha, Qatar., Nounesis G; National Center for Scientific Research 'Demokritos', Aghia Paraskevi, Greece., Lai FA; College of Medicine, Member of QU Health, Qatar University, Doha, Qatar.; College of Biomedical & Life Sciences, Cardiff University, Cardiff, U.K.; Biomedical Research Center, Qatar University, Doha, Qatar., Nomikos M; College of Medicine, Member of QU Health, Qatar University, Doha, Qatar mixosn@yahoo.com mnomikos@qu.edu.qa.

Publikováno v: The Biochemical journal [Biochem J] 2018 Dec 14; Vol. 475 (24), pp. 3933-3948. Date of Electronic Publication: 2018 Dec 14.