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Autor:
Pulla Reddy Singam, Jufang Barkalow, Gary Callen, b Mukund Chorghade, c and Howard Foote, Michael Cain, a Roger Koops, Richard Pariza d, David Brown, Patel Ketan M, Subhash R. Patel, Ashok K. Gupta, Mahendra N. Deshpande
Publikováno v:
Organic Process Research & Development. 2:351-356
A scalable process for the novel antidepressant ABT-200, starting with 5,6-methylenedioxy-1-tetralone, is described. The new process improves the scale-up and safety concerns associated with the previously employed route to ABT-200. The scalable proc