Zobrazeno 1 - 10
of 663
pro vyhledávání: '"broadly neutralizing antibody"'
Autor:
Ameena Goga, Trisha Ramraj, Logashvari Naidoo, Brodie Daniels, Masefetsane Matlou, Terusha Chetty, Reshmi Dassaye, Nobubelo K. Ngandu, Laura Galli, Tarylee Reddy, Ishen Seocharan, Qondeni Ndlangamandla, Qholokazi September, Nokwanda Ngcobo, Mayuri Reddy, Tamon Cafun-Naidoo, Kubashni Woeber, Nitesha Jeenarain, Rabia Imamdin, Keshnee Maharajh, Ashmintha Ramjeth, Thobile Bhengu, Emma Clarence, Philippe Van de Perre, Thorkild Tylleskär, Nicolas Nagot, Jean-Pierre Moles, Penny L. Moore, Nonhlanhla N. Mkhize, Lucio Gama, Stefania Dispinseri, Priscilla Biswas, Gabriella Scarlatti, the PedMAb1 clinical trial team
Publikováno v:
BMC Infectious Diseases, Vol 24, Iss 1, Pp 1-17 (2024)
Abstract Background The ambitious goal to eliminate new pediatric HIV infections by 2030 requires accelerated prevention strategies in high-risk settings such as South Africa. One approach could be pre-exposure prophylaxis (PrEP) with broadly neutral
Externí odkaz:
https://doaj.org/article/289c4aae8d584a3bb56f8bc46eb6cc68
Autor:
Mengxiao Luo, Runhong Zhou, Bingjie Tang, Hang Liu, Bohao Chen, Na Liu, Yufei Mo, Pengfei Zhang, Ye Lim Lee, Jonathan Daniel Ip, Allen Wing-Ho Chu, Wan-Mui Chan, Hiu-On Man, Yuting Chen, Kelvin Kai-Wang To, Kwok-Yung Yuen, Shangyu Dang, Zhiwei Chen
Publikováno v:
EBioMedicine, Vol 108, Iss , Pp 105354- (2024)
Summary: Background: The spread of emerging SARS-CoV-2 immune escape sublineages, especially JN.1 and KP.2, has resulted in new waves of COVID-19 globally. The evolving memory B cell responses elicited by the parental Omicron variants to subvariants
Externí odkaz:
https://doaj.org/article/d26a7daabd354e91b2e59e929858c0b6
Autor:
Minghui Li, Chaoyue Zhao, Jialu Shi, Xun Wang, Yuanchen Liu, Xiaoyu Zhao, Guonan Cai, Hin Chu, Pengfei Wang
Publikováno v:
Emerging Microbes and Infections, Vol 13, Iss 1 (2024)
Human coronaviruses such as SARS-CoV, MERS-CoV, and SARS-CoV-2 have recurrently emerged as significant pathogens, causing severe respiratory illnesses and presenting challenges to monoclonal antibody therapeutics due to their rapid evolution, particu
Externí odkaz:
https://doaj.org/article/50b7be676f08459e88685f7bf60c61bd
Autor:
Jianliang Xu, Tongqing Zhou, Krisha McKee, Baoshan Zhang, Cuiping Liu, Alexandra F. Nazzari, Amarendra Pegu, Chen‐Hsiang Shen, Jordan E. Becker, Michael F. Bender, Payton Chan, Anita Changela, Ridhi Chaudhary, Xuejun Chen, Tal Einav, Young Do Kwon, Bob C. Lin, Mark K. Louder, Jonah S. Merriam, Nicholas C. Morano, Sijy O'Dell, Adam S. Olia, Reda Rawi, Ryan S. Roark, Tyler Stephens, I‐Ting Teng, Emily Tourtellott‐Fogt, Shuishu Wang, Eun Sung Yang, Lawrence Shapiro, Yaroslav Tsybovsky, Nicole A. Doria‐Rose, Rafael Casellas, Peter D. Kwong
Publikováno v:
Advanced Science, Vol 11, Iss 26, Pp n/a-n/a (2024)
Abstract Broadly neutralizing antibodies are proposed as therapeutic and prophylactic agents against HIV‐1, but their potency and breadth are less than optimal. This study describes the immunization of a llama with the prefusion‐stabilized HIV‐
Externí odkaz:
https://doaj.org/article/2af27b428ce0453586e0f60b99fd2446
Publikováno v:
Viruses, Vol 16, Iss 10, p 1588 (2024)
Although combination antiretroviral therapy (ART) has been a landmark achievement for the treatment of human immunodeficiency virus (HIV), an HIV cure has remained elusive. Elimination of latent HIV reservoirs that persist throughout HIV infection is
Externí odkaz:
https://doaj.org/article/de68b5a0fb304d55bc9aea030444186b
Autor:
Adam S. Olia, Madhu Prabhakaran, Darcy R. Harris, Crystal Sao-Fong Cheung, Rebecca A. Gillespie, Jason Gorman, Abigayle Hoover, Nicholas C. Morano, Amine Ourahmane, Abhinaya Srikanth, Shuishu Wang, Weiwei Wu, Tongqing Zhou, Sarah F. Andrews, Masaru Kanekiyo, Lawrence Shapiro, Adrian B. McDermott, Peter D. Kwong
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
The VH6-1 class of antibodies includes some of the broadest and most potent antibodies that neutralize influenza A virus. Here, we elicit and isolate anti-idiotype antibodies against germline versions of VH6-1 antibodies, use these to sort human leuk
Externí odkaz:
https://doaj.org/article/086e3f3dbf7c436b9fc0aa65fce2326a
Publikováno v:
Vaccines, Vol 12, Iss 8, p 927 (2024)
Although many people have been vaccinated against COVID-19, infections with SARS-CoV-2 seem hard to avoid. There is a need to develop more effective vaccines and immunization strategies against emerging variants of infectious diseases. To understand
Externí odkaz:
https://doaj.org/article/4e4dfe0bb64244f3884d9c2f21bcb610
Autor:
Chang-Kyu Heo, Won-Hee Lim, Ki-Beom Moon, Jihyun Yang, Sang Jick Kim, Hyun-Soon Kim, Doo-Jin Kim, Eun-Wie Cho
Publikováno v:
Vaccines, Vol 12, Iss 6, p 676 (2024)
Approved COVID-19 vaccines primarily induce neutralizing antibodies targeting the receptor-binding domain (RBD) of the SARS-CoV-2 spike (S) protein. However, the emergence of variants of concern with RBD mutations poses challenges to vaccine efficacy
Externí odkaz:
https://doaj.org/article/5d3cc60b97e84872af4f17fef3c28f83
Autor:
Ghofrani J, Bowen A, Chen J, Balakrishnan PB, Powell AB, Cherukula K, Cruz CRY, Jones RB, Lynch RM, Sweeney EE, Fernandes R
Publikováno v:
International Journal of Nanomedicine, Vol Volume 18, Pp 4055-4066 (2023)
Joshua Ghofrani,1,2 Allan Bowen,2 Jie Chen,2 Preethi Bala Balakrishnan,2 Allison B Powell,1,2 Kondareddy Cherukula,2 Conrad Russell Y Cruz,2,3 R Brad Jones,4 Rebecca M Lynch,5 Elizabeth E Sweeney,2,6 Rohan Fernandes1,2,7 1The Institute for Biomedical
Externí odkaz:
https://doaj.org/article/c386ef98a5174665b0d5fd3230365028
Autor:
Lujia Sun, Bo Chen, Xianbo Liu, Yun Zhu, Guangxu Zhang, Xiaoxing Liang, Lixiao Xing, Wei Xu, Shibo Jiang, Xinling Wang
Publikováno v:
Current Research in Microbial Sciences, Vol 7, Iss , Pp 100263- (2024)
The highly conserved hydrophobic pocket region of HIV-1 gp41 NHR triple-stranded coiled coil is crucial for the binding of CHR to NHR to form a six-helix bundle (6-HB). This pocket is only exposed instantaneously during fusion, making it an ideal tar
Externí odkaz:
https://doaj.org/article/b1599c8680fd4699ba607c86828fa3e0