Výsledky vyhledávání - "breast hypoxia"

Akademický článek

Benzenesulfonamides with different rigidity-conferring linkers as carbonic anhydrase inhibitors: an insight into the antiproliferative effect on glioblastoma, pancreatic, and breast cancer cells

Autor: Francesco Liguori, Simone Carradori, Roberto Ronca, Sara Rezzola, Serena Filiberti, Fabrizio Carta, Marta Turati, Claudiu T. Supuran

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 1857-1869 (2022)

Among the chemotypes studied for selective inhibition of tumour-associated carbonic anhydrases (CAs), SLC-0111, a ureido-bearing benzenesulfonamide CA IX inhibitor, displayed promising antiproliferative effects in cancer cells in vitro and in vivo, b

Externí odkaz: https://doaj.org/article/ec590cbc66a448ba909f6c31d3ad72a3

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Akademický článek

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Hypoxia modulates the stem cell population and induces EMT in the MCF-10A breast epithelial cell line

Autor: Sarah Dean, Carl S. Daly, Myra E. Conway, David Qualtrough, Mai Ahmed Shafei, Arwa Flemban

Publikováno v: Oncology Reports

A common feature among pre-malignant lesions is the induction of hypoxia through increased cell propagation and reduced access to blood flow. Hypoxia in breast cancer has been associated with poor patient prognosis, resistance to chemotherapy and inc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae232b4925a0011bddfb9e9896b5d1c4
https://doi.org/10.3892/or.2017.6125

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