Zobrazeno 1 - 10
of 7 212
pro vyhledávání: '"breakpoint cluster region"'
Publikováno v:
Iraqi Journal of Hematology, Vol 12, Iss 2, Pp 176-183 (2023)
BACKGROUND: Chronic myeloid leukemia (CML) has been well recognized as an exemplary instance of a malignant disease characterized by a distinctive molecular occurrence, namely the presence of the breakpoint cluster region (BCR)-c-ABL oncogene 1 (ABL1
Externí odkaz:
https://doaj.org/article/6c2f295e00424f19933c8354e04acf73
Autor:
Rafael Amorim Belo Nunes, Precil Diego Miranda de Menezes Neves, Leandro Menezes Alves da Costa, Philip Bachour, Marcelo José de Carvalho Cantarelli, Gustavo Bernardes de Figueiredo Oliveira, Álvaro Avezum Jr.
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 10 (2023)
BackgroundBreakpoint cluster region-Abelson gene (BCR-ABL) tyrosine kinase inhibitors (TKIs) have revolutionized the treatment of patients with chronic myeloid leukemia (CML). However, concern has arisen about the cardiac safety profile of these drug
Externí odkaz:
https://doaj.org/article/44e65b622a364ef68ed0c128015029dc
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Several tyrosine kinase inhibitors (TKIs) have been developed as targeted therapies to inhibit the oncogenic activity of several tyrosine kinases in chronic myeloid leukemia (CML), acute lymphoid leukemia (ALL), gastrointestinal stromal tumor (GIST),
Externí odkaz:
https://doaj.org/article/f64df5eaf56f4047833f88b7ea030076
Autor:
Amin Huma, Ahmed Suhaib
Publikováno v:
Open Medicine, Vol 16, Iss 1, Pp 904-912 (2021)
Depending on breakpoints of rearrangement different types of BCR–ABL fusion protein can be generated in patients of chronic myeloid leukemia (CML). The aim of this study is to observe frequencies of major transcripts in CML patients by reverse tran
Externí odkaz:
https://doaj.org/article/506ed547dec04fe48c66cd72fecf7eb5
Autor:
Min-Hye Kim, Gi-Eun Yang, Mi-So Jeong, Jeong-Yeon Mun, Sang-Yeop Lee, Jong-Kil Nam, Yung Hyun Choi, Tae Nam Kim, Sun-Hee Leem
Publikováno v:
BMC Medical Genomics, Vol 14, Iss 1, Pp 1-12 (2021)
Abstract Background ABL1 is primarily known as a leukemia-related oncogene due to translocation, but about 2.2% of ABL1 mutations have been identified in bladder cancer, and high expression in solid cancer has also been detected. Methods Here, we use
Externí odkaz:
https://doaj.org/article/406102819d384dd18d51c29bdec1b7fd
Publikováno v:
Human Genomics, Vol 13, Iss 1, Pp 1-9 (2019)
Abstract Background RUNX1 gene, a master regulator of the hematopoietic process, participates in pathological conditions as a partner for several genes in chromosomal translocations. One of the most frequent chromosomal translocations found in acute
Externí odkaz:
https://doaj.org/article/ac1b68fd6cf1490992ed862c477f8339
Autor:
Karthik B K. Bommannan, Shano Naseem, Neelam Varma, Jogeshwar Binota, Pankaj Malhotra, Subhash Varma
Publikováno v:
Journal of Applied Hematology, Vol 10, Iss 2, Pp 51-60 (2019)
BACKGROUND: Cytogenetic evaluation is required till a complete cytogenetic remission is achieved in chronic myelogenous leukemia (CML) patients on tyrosine kinase inhibitor (TKI) therapy. The routine dual colour fluorescence in situ hybridization (FI
Externí odkaz:
https://doaj.org/article/b810e42ad7a549989e16cb095ed1c069
Autor:
Kolijn, Martijn, Saberi Hosnijeh, Fatemeh, Spath, Florentin, Hengeveld, P., Andreas, Agathangelidis, Saleh, Manal, Casabonne, Delphine, Benavente, Yolanda, Jerkeman, Mats, Aguado, Antonio, Barricante, Aurelio, Besson, Caroline M, Sanchez, Maria-Jose, Chirlaque, Maria Dolores, Masala, Giovanna, Sacerdote, Carlotta, Grioni, Sara, Schulze, M.B., Nieters, Alexandra, Engelfriet, Peter M, Hultdin, Magnus, McKay, J., Vermeulen, Roel, Langerak, Anton W, IRAS OH Epidemiology Chemical Agents
Publikováno v:
Blood, 139(10), 1557-1563. American Society of Hematology
Blood, 139(10). American Society of Hematology
Blood, 139(10). American Society of Hematology
Chronic lymphocytic leukemia (CLL) is preceded by monoclonal B-cell lymphocytosis (MBL), a CLL precursor state with a prevalence of up to 12% in aged individuals; however, the duration of MBL and the mechanisms of its evolution to CLL remain largely
Publikováno v:
Clinical Immunology ISBN: 9780702081651
The establishment of the mature B-cell pool involves a delicate balance that ensures a broad spectrum of specificities and at the same time avoids self-reactivity. B lymphocytes develop from hematopoietic stem cells and their progeny are characterize
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa8b93442b7571d80ed99254f670b97a
https://doi.org/10.1016/b978-0-7020-8165-1.00007-1
https://doi.org/10.1016/b978-0-7020-8165-1.00007-1
Autor:
Sebastian Wolf, Constanze Schneider, Roland Schmitz, Kwang Seok Lee, Mikolaj Slabicki, Hans Christian Reinhardt, Henning Urlaub, Craig J. Thomas, Anne C. Wilke, Hubert Serve, Fernando Kreuz, Joshua D. Rabinowitz, Dominique Jahn, Michele Ceribelli, Christian Brandts, Kimberly Stegmaier, Matthew G. Vander Heiden, Caroline A. Lewis, Thomas Oellerich, Kamil Bojarczuk, Thorsten Zenz, Daniel J. Hodson, Sara A Rieke, Yana Pikman, James Q Wang, Xincheng Xu, Michael Engelke, Hahn Kim, Hanibal Bohnenberger, Zana A. Coulibaly, Clemens A Schmitt, Federico Comoglio, James D. Phelan, Louis M. Staudt, Carmen Doebele, Sebastian Scheich, Björn Chapuy, Frank Schnuetgen, Gero Knittel, Frances A. Tosto, Philipp Stroebel, Alena Zindel, Björn Häupl, Philipp Stauder, Thanh Hung Dang
Publikováno v:
Blood
Burkitt lymphoma (BL) is an aggressive lymphoma type that is currently treated by intensive chemoimmunotherapy. Despite the favorable clinical outcome for most patients with BL, chemotherapy-related toxicity and disease relapse remain major clinical