Zobrazeno 1 - 10
of 1 335
pro vyhledávání: '"brain organoids"'
Publikováno v:
Jichu yixue yu linchuang, Vol 44, Iss 9, Pp 1208-1213 (2024)
In recent years, with rapid development of technology of regenerative medicine and tissue engineering, brain organoids, as an innovative in vitro model system, have become a hot spot in neuroscience research and drug development. Brain organoids simu
Externí odkaz:
https://doaj.org/article/134ed3b8a377454bbd3603a2902ffd7b
Autor:
Ying Su, Aimei Liu, Hongguang Chen, Qingjie Chen, Bo Zhao, Runze Gao, Kangwei Zhang, Tie Peng, Zhenwang Zhang, Changhan Ouyang, Dan Zhu
Publikováno v:
Molecular Brain, Vol 17, Iss 1, Pp 1-14 (2024)
Abstract Human embryonic stem cells and human induced pluripotent stem cells may be used to create 3D tissues called brain organoids. They duplicate the physiological and pathological characteristics of human brain tissue more faithfully in terms of
Externí odkaz:
https://doaj.org/article/64945afa33304cbda9399da8521ba339
Autor:
Jong-Tae Kim, Kang Song, Sung Woo Han, Dong Hyuk Youn, Harry Jung, Keun-Suh Kim, Hyo-Jung Lee, Ji Young Hong, Yong-Jun Cho, Sung-Min Kang, Jin Pyeong Jeon
Publikováno v:
Cell & Bioscience, Vol 14, Iss 1, Pp 1-18 (2024)
Abstract Clinical outcome after traumatic brain injury (TBI) is closely associated conditions of other organs, especially lungs as well as degree of brain injury. Even if there is no direct lung damage, severe brain injury can enhance sympathetic ton
Externí odkaz:
https://doaj.org/article/a1333ceffce7493286d56a62a2492116
Autor:
Hugo Alonso-Olivares, Margarita M. Marques, Anna Prieto-Colomina, Lorena López-Ferreras, Nicole Martínez-García, Alberto Vázquez-Jiménez, Victor Borrell, Maria C. Marin, Rosalia Fernandez-Alonso
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
IntroductionNeurogenesis is tightly regulated in space and time, ensuring the correct development and organization of the central nervous system. Critical regulators of brain development and morphogenesis in mice include two members of the p53 family
Externí odkaz:
https://doaj.org/article/a0f4649edac84157a5122025cfc2b2a7
Autor:
Hannah C. Leeson, Julio Aguado, Cecilia Gómez-Inclán, Harman Kaur Chaggar, Atefah Taherian Fard, Zoe Hunter, Martin F. Lavin, Alan Mackay-Sim, Ernst J. Wolvetang
Publikováno v:
Neurobiology of Disease, Vol 199, Iss , Pp 106562- (2024)
Ataxia Telangiectasia (AT) is a rare disorder caused by mutations in the ATM gene and results in progressive neurodegeneration for reasons that remain poorly understood. In addition to its central role in nuclear DNA repair, ATM operates outside the
Externí odkaz:
https://doaj.org/article/b826d148b82f43529a6250e191ea9f40
Autor:
Adam Pavlinek, Dwaipayan Adhya, Alex Tsompanidis, Varun Warrier, Anthony C. Vernon, Madeline Lancaster, Jonathan Mill, Deepak P. Srivastava, Simon Baron-Cohen, Carrie Allison, Rosie Holt, Paula Smith, Tracey Parsons, Joanna Davis, Matthew Hassall, Daniel H. Geschwind, Alexander EP. Heazell, Alice Franklin, Rosie Bamford, Jonathan Davies, Matthew E. Hurles, Hilary C. Martin, Mahmoud Mousa, David H. Rowitch, Kathy K. Niakan, Graham J. Burton, Fateneh Ghafari, Lucia Dutan-Polit, Madeline A. Lancaster, Ilaria Chiaradia, Tal Biron-Shental, Lidia V. Gabis
Publikováno v:
Biological Psychiatry Global Open Science, Vol 4, Iss 5, Pp 100343- (2024)
Sex differences are widespread during neurodevelopment and play a role in neuropsychiatric conditions such as autism, which is more prevalent in males than females. In humans, males have been shown to have larger brain volumes than females with devel
Externí odkaz:
https://doaj.org/article/696dcf6345f647389e6fcc214263b982
Autor:
Kaneyasu Nishimura, Hironobu Osaki, Kotaro Tezuka, Daisuke Nakashima, Shintaro Numata, Yoshito Masamizu
Publikováno v:
Frontiers in Neural Circuits, Vol 18 (2024)
Recent advances in human pluripotent stem cell (hPSC) technologies have prompted the emergence of new research fields and applications for human neurons and brain organoids. Brain organoids have gained attention as an in vitro model system that recap
Externí odkaz:
https://doaj.org/article/506dcb9d835843a18fafd931d3f589e5
Autor:
Sarah Fernandes, Jasmin Revanna, Joshua Pratt, Nicholas Hayes, Maria C. Marchetto, Fred H. Gage
Publikováno v:
Frontiers in Neuroscience, Vol 18 (2024)
Age-related neurodegenerative diseases, like Alzheimer’s disease (AD), are challenging diseases for those affected with no cure and limited treatment options. Functional, human derived brain tissues that represent the diverse genetic background and
Externí odkaz:
https://doaj.org/article/03dfc399614b4a6989b5d881186043fa
Autor:
Shi‐Bo Xu, Xin‐Rui Li, Pan Fan, Xiyang Li, Yuan Hong, Xiao Han, Shanshan Wu, Chu Chu, Yuejun Chen, Min Xu, Mingyan Lin, Xing Guo, Yan Liu
Publikováno v:
Advanced Science, Vol 11, Iss 28, Pp n/a-n/a (2024)
Abstract Human stem cells and derivatives transplantation are widely used to treat nervous system diseases, while the fate determination of transplanted cells is not well elucidated. To explore cell fate changes of human brain organoids before and af
Externí odkaz:
https://doaj.org/article/5c7d05072fd14583a59a7e4b2a9461ed