Zobrazeno 1 - 10
of 296
pro vyhledávání: '"brain microvessels"'
Autor:
Gloria Solano-Aguilar, Gregory Matuszek, Nirupa R. Matthan, Alice H. Lichtenstein, Xuedi Wang, Sukla Lakshman, Kathryn Barger, Joseph F. Urban, Aleksey Molokin, Rachel E. Bennett, Bradley T. Hyman, Stefania Lamon-Fava
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Diet is a potentially modifiable neurodegenerative disease risk factor. We studied the effects of a typical Western diet (WD; high in refined carbohydrates, cholesterol and saturated fat), relative to a heart-healthy diet (HHD; high in unref
Externí odkaz:
https://doaj.org/article/7132af9e0f0c4276b4647f0cda0ab6c0
Autor:
Michelle A. Erickson, Richard S. Johnson, Mamatha Damodarasamy, Michael J. MacCoss, C. Dirk Keene, William A. Banks, May J. Reed
Publikováno v:
Fluids and Barriers of the CNS, Vol 21, Iss 1, Pp 1-17 (2024)
Abstract Brain microvascular dysfunction is an important feature of Alzheimer’s disease (AD). To better understand the brain microvascular molecular signatures of AD, we processed and analyzed isolated human brain microvessels by data-independent a
Externí odkaz:
https://doaj.org/article/e994c165eb8342aa9d8dc47f7b392243
Akademický článek
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Akademický článek
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Autor:
Nina Choublier, Meryam Taghi, Marie-Claude Menet, Morgane Le Gall, Johanna Bruce, Philippe Chafey, François Guillonneau, Amélie Moreau, Claire Denizot, Yannick Parmentier, Samir Nakib, Didier Borderie, Haniaa Bouzinba-Segard, Pierre-Olivier Couraud, Sandrine Bourdoulous, Xavier Declèves
Publikováno v:
Fluids and Barriers of the CNS, Vol 19, Iss 1, Pp 1-24 (2022)
Abstract Endothelial cells (ECs) are constantly submitted in vivo to hemodynamical forces derived from the blood circulation, including shear stress (SS). ECs are able to detect SS and consequently adapt their phenotype, thus affecting many endotheli
Externí odkaz:
https://doaj.org/article/19fc31ee25ba4de8bf040d26425522eb
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Elena Puris, Seppo Auriola, Sabrina Petralla, Robin Hartman, Mikko Gynther, Elizabeth C.M. de Lange, Gert Fricker
Publikováno v:
Neurobiology of Disease, Vol 169, Iss , Pp 105741- (2022)
There is growing evidence that membrane transporters expressed at the blood-brain barrier (BBB) and brain parenchymal cells play an important role in Alzheimer's disease (AD) development and progression. However, quantitative information about change
Externí odkaz:
https://doaj.org/article/195f09b68eac45ce9396e5e3fb99bd6a
Autor:
Wandong Zhang, Qing Yan Liu, Arsalan S. Haqqani, Ziying Liu, Caroline Sodja, Sonia Leclerc, Ewa Baumann, Christie E. Delaney, Eric Brunette, Danica B. Stanimirovic
Publikováno v:
Pharmaceutics, Vol 15, Iss 5, p 1563 (2023)
Background: ATP-binding cassette (ABC) transporters comprise a superfamily of genes encoding membrane proteins with nucleotide-binding domains (NBD). These transporters, including drug efflux across the blood–brain barrier (BBB), carry a variety of
Externí odkaz:
https://doaj.org/article/91954c0f4d754cb0af20377522dc9cdd
Autor:
Rachel E. Bennett, Miwei Hu, Analiese Fernandes, Marta Perez-Rando, Ashley Robbins, Tarun Kamath, Simon Dujardin, Bradley T. Hyman
Publikováno v:
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-16 (2020)
Abstract Microangiopathy, including proliferation of small diameter capillaries, increasing vessel tortuosity, and increased capillary blockage by leukocytes, was previously observed in the aged rTg4510 mouse model. Similar gene expression changes re
Externí odkaz:
https://doaj.org/article/abc4d2d9442f4705a8bfeb396fb4e6d4
Autor:
Wandong Zhang, Qing Yan Liu, Arsalan S. Haqqani, Sonia Leclerc, Ziying Liu, François Fauteux, Ewa Baumann, Christie E. Delaney, Dao Ly, Alexandra T. Star, Eric Brunette, Caroline Sodja, Melissa Hewitt, Jagdeep K. Sandhu, Danica B. Stanimirovic
Publikováno v:
Fluids and Barriers of the CNS, Vol 17, Iss 1, Pp 1-17 (2020)
Abstract Receptor-mediated transcytosis (RMT) is a principal pathway for transport of macromolecules essential for brain function across the blood–brain barrier (BBB). Antibodies or peptide ligands which bind RMT receptors are often co-opted for br
Externí odkaz:
https://doaj.org/article/0b303c3f54f44cd1a6df157f40dd7f54