Zobrazeno 1 - 10
of 509
pro vyhledávání: '"brain lipids"'
Publikováno v:
Heliyon, Vol 10, Iss 19, Pp e38871- (2024)
Several studies emphasized on the preventive and therapeutic potential of Docosahexaenoic Acid (DHA, 22:6n-3) supplementation in chronic and age-related disorders including neurodegenerative diseases. Researchers principally studied the cerebral accr
Externí odkaz:
https://doaj.org/article/3d3bb15b552844418f7843628258dcdc
Autor:
Danielle A. Becktel, Jennifer B. Frye, Elizabeth H. Le, Susan A. Whitman, Rick G. Schnellmann, Helena W. Morrison, Kristian P. Doyle
Publikováno v:
Journal of Lipid Research, Vol 65, Iss 9, Pp 100614- (2024)
Ischemic stroke remains a leading cause of mortality and long-term disability worldwide, necessitating efforts to identify biomarkers for diagnosis, prognosis, and treatment monitoring. The present study aimed to identify novel plasma biomarkers of n
Externí odkaz:
https://doaj.org/article/feeba4deab6342fbba07121e68c902ff
Autor:
Derek Besch, Drew R. Seeger, Brennon Schofield, Svetlana A. Golovko, Meredith Parmer, Mikhail Y. Golovko
Publikováno v:
Journal of Lipid Research, Vol 65, Iss 7, Pp 100583- (2024)
Dramatic postmortem prostanoid (PG) enzymatic synthesis in the brain causes a significant artifact during PG analysis. Thus, enzyme deactivation is required for an accurate in situ endogenous PG quantification. To date, the only method for preventing
Externí odkaz:
https://doaj.org/article/7ec5587d89cc472796beff42a0b10d23
Publikováno v:
Journal of Lipid Research, Vol 65, Iss 6, Pp 100555- (2024)
Cytochrome P450 46A1 (CYP46A1) is the CNS-specific cholesterol 24-hydroxylase that controls cholesterol elimination and turnover in the brain. In mouse models, pharmacologic CYP46A1 activation with low-dose efavirenz or by gene therapy mitigates the
Externí odkaz:
https://doaj.org/article/c33367ff731c493e950729642ca5ebf6
Autor:
Michele Dei Cas, Linda Montavoci, Claudia Pasini, Anna Caretti, Sara Penati, Carla Martinelli, Umberto Gianelli, Sara Casati, Francesca Nardecchia, Annalaura Torella, Nicola Brunetti-Pierri, Marco Trinchera
Publikováno v:
Journal of Lipid Research, Vol 65, Iss 3, Pp 100517- (2024)
The last step of ex novo ceramide biosynthesis consists of the conversion of dihydroceramide into ceramide catalyzed by sphingolipid Δ4-desaturase DEGS1. DEGS1 variants were found to be responsible for heterogeneous clinical pictures belonging to th
Externí odkaz:
https://doaj.org/article/c066db706c1b439f81926ed07b97410d
Autor:
Maria L. Allende, Y. Terry Lee, Colleen Byrnes, Cuiling Li, Galina Tuymetova, Jenna Y. Bakir, Elena-Raluca Nicoli, Virginia K. James, Jennifer S. Brodbelt, Cynthia J. Tifft, Richard L. Proia
Publikováno v:
Journal of Lipid Research, Vol 64, Iss 12, Pp 100463- (2023)
GM1 gangliosidosis is a neurodegenerative disorder caused by mutations in the GLB1 gene, which encodes lysosomal β-galactosidase. The enzyme deficiency blocks GM1 ganglioside catabolism, leading to accumulation of GM1 ganglioside and asialo-GM1 gang
Externí odkaz:
https://doaj.org/article/94f9b0fdff3447668849eed7667b5c00
Autor:
Peter Hofer, Gernot F. Grabner, Mario König, Hao Xie, Dominik Bulfon, Anton E. Ludwig, Heimo Wolinski, Robert Zimmermann, Rudolf Zechner, Christoph Heier
Publikováno v:
Journal of Lipid Research, Vol 64, Iss 11, Pp 100457- (2023)
Intracellular lipolysis—the enzymatic breakdown of lipid droplet-associated triacylglycerol (TAG)—depends on the cooperative action of several hydrolytic enzymes and regulatory proteins, together designated as lipolysome. Adipose triglyceride lip
Externí odkaz:
https://doaj.org/article/bfc34bab37db460bab35c37681986747
Autor:
Ami Oguro, Taichi Fujiyama, Yasuhiro Ishihara, Chisato Kataoka, Megumi Yamamoto, Komyo Eto, Yoshihiro Komohara, Susumu Imaoka, Toshihide Sakuragi, Mayumi Tsuji, Eiji Shibata, Yaichiro Kotake, Takeshi Yamazaki
Publikováno v:
Journal of Lipid Research, Vol 64, Iss 11, Pp 100458- (2023)
Although pregnant women’s fish consumption is beneficial for the brain development of the fetus due to the DHA in fish, seafood also contains methylmercury (MeHg), which adversely affects fetal brain development. Epidemiological studies suggest tha
Externí odkaz:
https://doaj.org/article/e92ba8be57fa4b2ea88b871630551256
Autor:
Drew R. Seeger, Brennon Schofield, Derek Besch, Svetlana A. Golovko, Peddanna Kotha, Meredith Parmer, Shahram Solaymani-Mohammadi, Mikhail Y. Golovko
Publikováno v:
Journal of Lipid Research, Vol 64, Iss 11, Pp 100452- (2023)
Previously, we and others reported a rapid and dramatic increase in brain prostanoids (PG), including prostaglandins, prostacyclins, and thromboxanes, under ischemia that is traditionally explained through the activation of esterified arachidonic aci
Externí odkaz:
https://doaj.org/article/05757f17b6e94829ae02f7e9e56a72e9
Publikováno v:
Molecules, Vol 29, Iss 1, p 135 (2023)
The lanthanide metal gadolinium has been used in the healthcare industry as a paramagnetic contrast agent for years. Gadolinium deposition in brain tissue and kidneys has been reported following gadolinium-based contrast agent administration to patie
Externí odkaz:
https://doaj.org/article/f41d6dce61054f189a398265dd4ce134