Zobrazeno 1 - 10
of 559
pro vyhledávání: '"brain distribution"'
Publikováno v:
International Journal of Nanomedicine, Vol Volume 19, Pp 10885-10898 (2024)
Zheng Wan,1 Tianyi Liu,1 Ning Xu,1 Wenhao Zhu,2 Xiaoyu Zhang,2 Qin Liu,1 Haifeng Wang,2 Honglei Wang1 1Department of Neurovascular Surgery, The First Hospital of Jilin University, Changchun, Jilin Province, People’s Republic of China; 2Department o
Externí odkaz:
https://doaj.org/article/bce57b54404c46c6ade11ca00595c2d6
Autor:
Bo Li, Yujie Chen, Yan Zhou, Xuanran Feng, Guojun Gu, Shuang Han, Nianhao Cheng, Yawen Sun, Yiming Zhang, Jiahui Cheng, Qi Zhang, Wei Zhang, Jianhui Liu
Publikováno v:
Neural Regeneration Research, Vol 19, Iss 7, Pp 1593-1601 (2024)
Mitochondrial dysfunction is a hallmark of Alzheimer’s disease. We previously showed that neural stem cell-derived extracellular vesicles improved mitochondrial function in the cortex of APP/PS1 mice. Because Alzheimer’s disease affects the entir
Externí odkaz:
https://doaj.org/article/ced927e5f7be4de18c260e0af22a217f
Autor:
Weitong Song, Lu Bai, Pingxiang Xu, Yuming Zhao, Xuelin Zhou, Jie Xiong, Xiaorong Li, Ming Xue
Publikováno v:
Pharmaceutics, Vol 16, Iss 8, p 975 (2024)
Isoliquiritigenin (ISL) has excellent neuroprotective effects. However, its limitations, including poor solubility, low bioavailability, and low accumulation in the brain, restrict its clinical promotion. In this study, a novel type of ISL-loaded lip
Externí odkaz:
https://doaj.org/article/fa18da3eb8a04ddc87bdd63008a4a745
Autor:
Hyeon Seok Oh, Minkyu Choi, Tae Suk Lee, Yejin An, Eun Ji Park, Tae Hwan Kim, Soyoung Shin, Beom Soo Shin
Publikováno v:
Journal of Analytical Science and Technology, Vol 14, Iss 1, Pp 1-11 (2023)
Abstract Liraglutide is a glucagon-like peptide-1 (GLP-1) analog that has been utilized for the treatment of type 2 diabetes mellitus. Liraglutide at a higher dose also shows beneficial effects in weight loss, which prompted its widespread use as an
Externí odkaz:
https://doaj.org/article/b07bcb10e27f4179826bf72df7de214b
Autor:
Thapa Chhitij, Jo-Eun Seo, Taekwang Keum, Gyubin Noh, Santosh Bashyal, Shrawani Lamichhane, Jung Hwan Kim, Jae Heon Lee, Jee Hun Park, Jaewoong Choi, Se Hyun Song, Sangkil Lee
Publikováno v:
Drug Delivery, Vol 29, Iss 1, Pp 2330-2342 (2022)
Our study aimed to develop a self-microemulsifying drug delivery system for the poorly aqueous-soluble drug Coenzyme Q10, to improve the dissolution and the oral bioavailability. Excipients were selected based on their Coenzyme Q10 solubility, and th
Externí odkaz:
https://doaj.org/article/81f09ba2bd1743c7bdf4be6ab70471a3
Publikováno v:
International Journal of Nanomedicine, Vol Volume 17, Pp 3655-3670 (2022)
Weitong Song,1 Lu Bai,1 Yuya Yang,1 Yongchao Wang,2 Pingxiang Xu,1,3 Yuming Zhao,1 Xuelin Zhou,1,3 Xiaorong Li,1,3 Ming Xue1,3 1Department of Pharmacology, School of Basic Medical Sciences, Capital Medical University, Beijing, People’s Republic of
Externí odkaz:
https://doaj.org/article/a6beccf60d30490191f34b0180138314
Autor:
Adele Romano, Marzia Friuli, Barbara Eramo, Cristina Anna Gallelli, Justyna Barbara Koczwara, Elnaz Karimian Azari, Adrien Paquot, Myrtha Arnold, Wolfgang Langhans, Giulio G. Muccioli, Thomas Alexander Lutz, Silvana Gaetani
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
IntroductionOleoylethanolamide (OEA), an endogenous N-acylethanolamine acting as a gut-to-brain signal to control food intake and metabolism, has been attracting attention as a target for novel therapies against obesity and eating disorders. Numerous
Externí odkaz:
https://doaj.org/article/a4a71c269d254baab06ed62af0e9408d
Publikováno v:
Frontiers in Neuroanatomy, Vol 16 (2023)
IntroductionProtein O-linked mannose β1,2-N-acetylglucosaminyltransferase 1 (POMGNT1) is crucial for the elongation of O-mannosyl glycans. Mutations in POMGNT1 cause muscle-eye-brain (MEB) disease, one of the main features of which is anatomical abe
Externí odkaz:
https://doaj.org/article/1b3190bf5b04429484197f6469e4f20d
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Akademický článek
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