Zobrazeno 1 - 10
of 51
pro vyhledávání: '"brain cell types"'
Autor:
Nicholas K. O’Neill, Thor D. Stein, Junming Hu, Habbiburr Rehman, Joshua D. Campbell, Masanao Yajima, Xiaoling Zhang, Lindsay A. Farrer
Publikováno v:
BMC Bioinformatics, Vol 24, Iss 1, Pp 1-16 (2023)
Abstract Background Quantifying cell-type abundance in bulk tissue RNA-sequencing enables researchers to better understand complex systems. Newer deconvolution methodologies, such as MuSiC, use cell-type signatures derived from single-cell RNA-sequen
Externí odkaz:
https://doaj.org/article/5a782d5b442d41b5ab02fe13b0f301c3
Autor:
Veronika Pak, Quadri Adewale, Danilo Bzdok, Mahsa Dadar, Yashar Zeighami, Yasser Iturria-Medina
Publikováno v:
eLife, Vol 12 (2024)
For over a century, brain research narrative has mainly centered on neuron cells. Accordingly, most neurodegenerative studies focus on neuronal dysfunction and their selective vulnerability, while we lack comprehensive analyses of other major cell ty
Externí odkaz:
https://doaj.org/article/c91a0051471f4d7aa892e4c6b81ff5ff
Autor:
Jeffrey Fessel
Publikováno v:
Discover Mental Health, Vol 3, Iss 1, Pp 1-18 (2023)
Abstract Background Pharmacotherapy for most psychiatric conditions was developed from serendipitous observations of benefit from drugs prescribed for different reasons. An algorithmic approach to formulating pharmacotherapy is proposed, based upon w
Externí odkaz:
https://doaj.org/article/a9e5b7a05d5a4eef8f3bc920878b527c
Autor:
Iman Sadeghi, Juan D. Gispert, Emilio Palumbo, Manuel Muñoz-Aguirre, Valentin Wucher, Valeria D'Argenio, Gabriel Santpere, Arcadi Navarro, Roderic Guigo, Natàlia Vilor-Tejedor
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 4549-4561 (2022)
Neurodegenerative and neuropsychiatric disorders (ND-NPs) are multifactorial, polygenic and complex behavioral phenotypes caused by brain abnormalities. Large-scale collaborative efforts have tried to identify the genetic architecture of these condit
Externí odkaz:
https://doaj.org/article/aedc58d2e187429084e7189989cf72bb
Autor:
Easwaran Ramamurthy, Gwyneth Welch, Jemmie Cheng, Yixin Yuan, Laura Gunsalus, David A. Bennett, Li-Huei Tsai, Andreas R. Pfenning
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 15 (2023)
We profile genome-wide histone 3 lysine 27 acetylation (H3K27ac) of 3 major brain cell types from hippocampus and dorsolateral prefrontal cortex (dlPFC) of subjects with and without Alzheimer’s Disease (AD). We confirm that single nucleotide polymo
Externí odkaz:
https://doaj.org/article/ceb332e45eeb48778b5b9d9ca1cfaaef
Autor:
Jiacheng Dai, Yu Chen, Rujia Dai, Yi Jiang, Jianghua Tian, Sihan Liu, Meng Xu, Miao Li, Jiaqi Zhou, Chunyu Liu, Chao Chen
Publikováno v:
Frontiers in Neuroscience, Vol 15 (2021)
Agonal factors, the conditions that occur just prior to death, can impact the molecular quality of postmortem brains, influencing gene expression results. Our study used gene expression data of 262 samples from ROSMAP with the detailed terminal state
Externí odkaz:
https://doaj.org/article/bc53f850eedd422cb332df2ec140b3f2
Autor:
John K. Mich, Lucas T. Graybuck, Erik E. Hess, Joseph T. Mahoney, Yoshiko Kojima, Yi Ding, Saroja Somasundaram, Jeremy A. Miller, Brian E. Kalmbach, Cristina Radaelli, Bryan B. Gore, Natalie Weed, Victoria Omstead, Yemeserach Bishaw, Nadiya V. Shapovalova, Refugio A. Martinez, Olivia Fong, Shenqin Yao, Marty Mortrud, Peter Chong, Luke Loftus, Darren Bertagnolli, Jeff Goldy, Tamara Casper, Nick Dee, Ximena Opitz-Araya, Ali Cetin, Kimberly A. Smith, Ryder P. Gwinn, Charles Cobbs, Andrew L. Ko, Jeffrey G. Ojemann, C. Dirk Keene, Daniel L. Silbergeld, Susan M. Sunkin, Viviana Gradinaru, Gregory D. Horwitz, Hongkui Zeng, Bosiljka Tasic, Ed S. Lein, Jonathan T. Ting, Boaz P. Levi
Publikováno v:
Cell Reports, Vol 34, Iss 13, Pp 108754- (2021)
Summary: Viral genetic tools that target specific brain cell types could transform basic neuroscience and targeted gene therapy. Here, we use comparative open chromatin analysis to identify thousands of human-neocortical-subclass-specific putative en
Externí odkaz:
https://doaj.org/article/f3fbdff3e4964a89bce059657aed05d2
Akademický článek
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Autor:
Zeng, Hongkui Zeng
To understand the function of the brain and how its dysfunction leads to brain diseases, it is essential to uncover the cell type composition of the brain, how the cell types are connected with each other and what their roles are in circuit function.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______325::d3c40ad74b5b47525005c2ddf1bae101
https://escholarship.org/uc/item/03w8c0f2
https://escholarship.org/uc/item/03w8c0f2
Akademický článek
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