Zobrazeno 1 - 10
of 247
pro vyhledávání: '"brain capillaries"'
Publikováno v:
Fluids and Barriers of the CNS, Vol 20, Iss 1, Pp 1-12 (2023)
Abstract Background The functions and protein expressions of the blood–brain barrier are changed throughout brain development following birth. This study aimed to develop a method to isolate brain capillaries from a single frozen neonatal mouse bra
Externí odkaz:
https://doaj.org/article/cfa326baa8ff4e819d5575dee0347b5c
Publikováno v:
Neurobiology of Disease, Vol 187, Iss , Pp 106298- (2023)
Dysfunction of the blood-brain barrier (BBB) is suggested to play a critical role in the pathological mechanisms of Parkinson's disease (PD). PD-related pathology such as alpha-synuclein accumulation and inflammatory processes potentially affect the
Externí odkaz:
https://doaj.org/article/217dcfb9dab846bf9240c64a11f7abef
Publikováno v:
Fluids and Barriers of the CNS, Vol 18, Iss 1, Pp 1-13 (2021)
Abstract Background Failure to clear Aβ from the brain is partly responsible for Aβ brain accumulation in Alzheimer’s disease (AD). A critical protein for clearing Aβ across the blood-brain barrier is the efflux transporter P-glycoprotein (P-gp)
Externí odkaz:
https://doaj.org/article/e55f794616b34ad4a714e16d390a6c63
Publikováno v:
Ecotoxicology and Environmental Safety, Vol 238, Iss , Pp 113620- (2022)
Sulfamethoxazole (SMX) is a widespread broad-spectrum bacteriostatic antibiotic. Its residual is frequently detected in the water and may therefore bioaccumulate in the brain of aquatic organisms via blood circulation. Brain capillaries toxicity is v
Externí odkaz:
https://doaj.org/article/ef752bc95d834e5cbdd59a51b3bbceac
Autor:
Hallel C. Paraiso, Xueqian Wang, Ping-Chang Kuo, Destin Furnas, Barbara A. Scofield, Fen-Lei Chang, Jui-Hung Yen, I-Chen Yu
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 14 (2020)
Brain microvasculature forms a specialized structure, the blood-brain barrier (BBB), to maintain homeostasis and integrity of the central nervous system (CNS). The BBB dysfunction is emerging as a critical contributor to multiple neurological disorde
Externí odkaz:
https://doaj.org/article/3e11009792f844cda3e2560db913c467
Autor:
Amy R. Nelson, Meghana A. Sagare, Yaoming Wang, Kassandra Kisler, Zhen Zhao, Berislav V. Zlokovic
Publikováno v:
Frontiers in Aging Neuroscience, Vol 12 (2020)
Brains depend on blood flow for the delivery of oxygen and nutrients essential for proper neuronal and synaptic functioning. French physiologist Rouget was the first to describe pericytes in 1873 as regularly arranged longitudinal amoeboid cells on c
Externí odkaz:
https://doaj.org/article/e8dddcae75f446d48d4b07898e99fcb2
Akademický článek
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Akademický článek
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Publikováno v:
eLife, Vol 7 (2018)
We recently reported that the inward-rectifier Kir2.1 channel in brain capillary endothelial cells (cECs) plays a major role in neurovascular coupling (NVC) by mediating a neuronal activity-dependent, propagating vasodilatory (hyperpolarizing) signal
Externí odkaz:
https://doaj.org/article/36a3959b2839416b96d944daee300602
Publikováno v:
Frontiers in Aging Neuroscience, Vol 10 (2018)
One characteristic of Alzheimer’s disease (AD) is excessive accumulation of amyloid-β (Aβ) in the brain. Aβ brain accumulation is, in part, due to a reduction in Aβ clearance from the brain across the blood-brain barrier. One key element that c
Externí odkaz:
https://doaj.org/article/e3183faacd1443919b3e9aba41429b4f