Zobrazeno 1 - 10
of 507
pro vyhledávání: '"brain Lipids"'
Publikováno v:
Journal of Lipid Research, Vol 65, Iss 11, Pp 100667- (2024)
Apolipoprotein B (APOB), a receptor-binding protein present in cholesterol-rich lipoproteins, has been implicated in Alzheimer's disease (AD). High levels of APOB-containing low-density lipoproteins (LDL) are linked to the pathogenesis of both early-
Externí odkaz:
https://doaj.org/article/d5a51dd6eada4d4f80a2a1d7067b7aa5
Publikováno v:
Heliyon, Vol 10, Iss 19, Pp e38871- (2024)
Several studies emphasized on the preventive and therapeutic potential of Docosahexaenoic Acid (DHA, 22:6n-3) supplementation in chronic and age-related disorders including neurodegenerative diseases. Researchers principally studied the cerebral accr
Externí odkaz:
https://doaj.org/article/3d3bb15b552844418f7843628258dcdc
Autor:
Danielle A. Becktel, Jennifer B. Frye, Elizabeth H. Le, Susan A. Whitman, Rick G. Schnellmann, Helena W. Morrison, Kristian P. Doyle
Publikováno v:
Journal of Lipid Research, Vol 65, Iss 9, Pp 100614- (2024)
Ischemic stroke remains a leading cause of mortality and long-term disability worldwide, necessitating efforts to identify biomarkers for diagnosis, prognosis, and treatment monitoring. The present study aimed to identify novel plasma biomarkers of n
Externí odkaz:
https://doaj.org/article/feeba4deab6342fbba07121e68c902ff
Autor:
Derek Besch, Drew R. Seeger, Brennon Schofield, Svetlana A. Golovko, Meredith Parmer, Mikhail Y. Golovko
Publikováno v:
Journal of Lipid Research, Vol 65, Iss 7, Pp 100583- (2024)
Dramatic postmortem prostanoid (PG) enzymatic synthesis in the brain causes a significant artifact during PG analysis. Thus, enzyme deactivation is required for an accurate in situ endogenous PG quantification. To date, the only method for preventing
Externí odkaz:
https://doaj.org/article/7ec5587d89cc472796beff42a0b10d23
Publikováno v:
Journal of Lipid Research, Vol 65, Iss 6, Pp 100555- (2024)
Cytochrome P450 46A1 (CYP46A1) is the CNS-specific cholesterol 24-hydroxylase that controls cholesterol elimination and turnover in the brain. In mouse models, pharmacologic CYP46A1 activation with low-dose efavirenz or by gene therapy mitigates the
Externí odkaz:
https://doaj.org/article/c33367ff731c493e950729642ca5ebf6
Autor:
Michele Cerasuolo, Irene Di Meo, Maria Chiara Auriemma, Giuseppe Paolisso, Michele Papa, Maria Rosaria Rizzo
Publikováno v:
Biomolecules, Vol 14, Iss 11, p 1362 (2024)
Aging induces complex changes in the lipid profiles across different areas of the brain. These changes can affect the function of brain cells and may contribute to neurodegenerative diseases such as Alzheimer’s disease. Research shows that while th
Externí odkaz:
https://doaj.org/article/094abd752aa546d7a04199499ae9450d
Autor:
Michele Dei Cas, Linda Montavoci, Claudia Pasini, Anna Caretti, Sara Penati, Carla Martinelli, Umberto Gianelli, Sara Casati, Francesca Nardecchia, Annalaura Torella, Nicola Brunetti-Pierri, Marco Trinchera
Publikováno v:
Journal of Lipid Research, Vol 65, Iss 3, Pp 100517- (2024)
The last step of ex novo ceramide biosynthesis consists of the conversion of dihydroceramide into ceramide catalyzed by sphingolipid Δ4-desaturase DEGS1. DEGS1 variants were found to be responsible for heterogeneous clinical pictures belonging to th
Externí odkaz:
https://doaj.org/article/c066db706c1b439f81926ed07b97410d
Autor:
Maria L. Allende, Y. Terry Lee, Colleen Byrnes, Cuiling Li, Galina Tuymetova, Jenna Y. Bakir, Elena-Raluca Nicoli, Virginia K. James, Jennifer S. Brodbelt, Cynthia J. Tifft, Richard L. Proia
Publikováno v:
Journal of Lipid Research, Vol 64, Iss 12, Pp 100463- (2023)
GM1 gangliosidosis is a neurodegenerative disorder caused by mutations in the GLB1 gene, which encodes lysosomal β-galactosidase. The enzyme deficiency blocks GM1 ganglioside catabolism, leading to accumulation of GM1 ganglioside and asialo-GM1 gang
Externí odkaz:
https://doaj.org/article/94f9b0fdff3447668849eed7667b5c00
Autor:
Peter Hofer, Gernot F. Grabner, Mario König, Hao Xie, Dominik Bulfon, Anton E. Ludwig, Heimo Wolinski, Robert Zimmermann, Rudolf Zechner, Christoph Heier
Publikováno v:
Journal of Lipid Research, Vol 64, Iss 11, Pp 100457- (2023)
Intracellular lipolysis—the enzymatic breakdown of lipid droplet-associated triacylglycerol (TAG)—depends on the cooperative action of several hydrolytic enzymes and regulatory proteins, together designated as lipolysome. Adipose triglyceride lip
Externí odkaz:
https://doaj.org/article/bfc34bab37db460bab35c37681986747
Autor:
Ami Oguro, Taichi Fujiyama, Yasuhiro Ishihara, Chisato Kataoka, Megumi Yamamoto, Komyo Eto, Yoshihiro Komohara, Susumu Imaoka, Toshihide Sakuragi, Mayumi Tsuji, Eiji Shibata, Yaichiro Kotake, Takeshi Yamazaki
Publikováno v:
Journal of Lipid Research, Vol 64, Iss 11, Pp 100458- (2023)
Although pregnant women’s fish consumption is beneficial for the brain development of the fetus due to the DHA in fish, seafood also contains methylmercury (MeHg), which adversely affects fetal brain development. Epidemiological studies suggest tha
Externí odkaz:
https://doaj.org/article/e92ba8be57fa4b2ea88b871630551256