Zobrazeno 1 - 10
of 48
pro vyhledávání: '"braak hypothesis"'
Autor:
Shenjie Wu, Randy W. Schekman
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 17 (2024)
An emerging theme in Parkinson’s disease (PD) is the propagation of α-synuclein pathology as the disease progresses. Research involving the injection of preformed α-synuclein fibrils (PFFs) in animal models has recapitulated the pathological spre
Externí odkaz:
https://doaj.org/article/027e66cd3dc14be7a5076c01f0a7f726
Publikováno v:
Cell & Bioscience, Vol 11, Iss 1, Pp 1-24 (2021)
Abstract Dementia with Lewy bodies (DLB) is epitomized by the pathognomonic manifestation of α-synuclein-laden Lewy bodies within selectively vulnerable neurons in the brain. By virtue of prion-like inheritance, the α-synuclein protein inexorably u
Externí odkaz:
https://doaj.org/article/132f2e779abe473f8e4a5e4bfd3b76e0
Autor:
Yogesh Bhattarai, Jie Si, Meng Pu, Owen A. Ross, Pamela J. McLean, Lisa Till, William Moor, Madhusudan Grover, Karunya K. Kandimalla, Kara G. Margolis, Gianrico Farrugia, Purna C. Kashyap
Publikováno v:
Gut Microbes, Vol 13, Iss 1 (2021)
Parkinson’s disease (PD) is a common neurodegenerative disorder characterized primarily by motor and non-motor gastrointestinal (GI) deficits. GI symptoms’ including compromised intestinal barrier function often accompanies altered gut microbiota
Externí odkaz:
https://doaj.org/article/bb7a910acd7e4c189dc74f02a3e7ce28
Autor:
Mónica Gómez-Benito, Noelia Granado, Patricia García-Sanz, Anne Michel, Mireille Dumoulin, Rosario Moratalla
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
Alpha-synuclein (α-Syn) is a key protein involved in Parkinson's disease (PD) pathology. PD is characterized by the loss of dopaminergic neuronal cells in the substantia nigra pars compacta and the abnormal accumulation and aggregation of α-Syn in
Externí odkaz:
https://doaj.org/article/d5ab88ced7474a9a857c7a0a171b5364
Autor:
Jamie C. Blair, Matthew J. Barrett, James Patrie, Joseph L. Flanigan, Scott A. Sperling, W. Jeffrey Elias, T. Jason Druzgal
Publikováno v:
Frontiers in Neurology, Vol 10 (2019)
Models which assess the progression of Lewy pathology in Parkinson's disease have proposed ascending spread in a caudal-rostral pattern. In-vivo human evidence for this theory is limited, in part because there are no biomarkers that allow for direct
Externí odkaz:
https://doaj.org/article/6eb04b2275c84c768e72f0d01355800e
Akademický článek
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Publikováno v:
Cell & Bioscience, Vol 11, Iss 1, Pp 1-24 (2021)
Cell & Bioscience
Cell & Bioscience
Dementia with Lewy bodies (DLB) is epitomized by the pathognomonic manifestation of α-synuclein-laden Lewy bodies within selectively vulnerable neurons in the brain. By virtue of prion-like inheritance, the α-synuclein protein inexorably undergoes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7805706aa89aade44c300eb93333000e
https://doaj.org/article/132f2e779abe473f8e4a5e4bfd3b76e0
https://doaj.org/article/132f2e779abe473f8e4a5e4bfd3b76e0
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Kara, Eleanna, Crimi, Alessandro, Wiedmer, Anne, Emmenegger, Marc, Manzoni, Claudia, Bandres-Ciga, Sara, D’Sa, Karishma, Reynolds, Regina H., Botía, Juan A., Losa, Marco, Lysenko, Veronika, Carta, Manfredi, Heinzer, Daniel, Avar, Merve, Chincisan, Andra, Blauwendraat, Cornelis, García-Ruiz, Sonia, Pease, Daniel, Mottier, Lorene, Carrella, Alessandra, Beck-Schneider, Dezirae, Magalhães, Andreia D., Aemisegger, Caroline, Theocharides, Alexandre P.A., Fan, Zhanyun, Marks, Jordan D., Hopp, Sarah C., Abramov, Andrey Y., Lewis, Patrick A., Ryten, Mina, Hardy, John, Hyman, Bradley T., Aguzzi, Adriano
Publikováno v:
Cell Reports
Summary Neuropathological and experimental evidence suggests that the cell-to-cell transfer of α-synuclein has an important role in the pathogenesis of Parkinson’s disease (PD). However, the mechanism underlying this phenomenon is not fully unders
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4653ac240babe323de43c6b881a2f649
https://doi.org/10.5167/uzh-204144
https://doi.org/10.5167/uzh-204144
Autor:
Gianrico Farrugia, William Moor, Purna C. Kashyap, Kara Gross Margolis, Owen A. Ross, Yogesh Bhattarai, Meng Pu, Karunya K. Kandimalla, Jie Si, Lisa Till, Pamela J. McLean, Madhusudan Grover
Publikováno v:
Gut Microbes
article-version (VoR) Version of Record
Gut Microbes, Vol 13, Iss 1 (2021)
article-version (VoR) Version of Record
Gut Microbes, Vol 13, Iss 1 (2021)
Parkinson’s disease (PD) is a common neurodegenerative disorder characterized primarily by motor and non-motor gastrointestinal (GI) deficits. GI symptoms’ including compromised intestinal barrier function often accompanies altered gut microbiota
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec83dc5711aa7b2895713aae23cebc28
http://europepmc.org/articles/PMC7833732
http://europepmc.org/articles/PMC7833732