Neural tube-associated boundary caps are a major source of mural cells in the skin

Autor: Gaspard Gerschenfeld, Fanny Coulpier, Aurélie Gresset, Pernelle Pulh, Bastien Job, Thomas Topilko, Julie Siegenthaler, Maria Eleni Kastriti, Isabelle Brunet, Patrick Charnay, Piotr Topilko

Publikováno v: eLife, Vol 12 (2023)

In addition to their roles in protecting nerves and increasing conduction velocity, peripheral glia plays key functions in blood vessel development by secreting molecules governing arteries alignment and maturation with nerves. Here, we show in mice

Externí odkaz: https://doaj.org/article/f791afb5a092412fabba20cf586ad994

Cellular Origin, Tumor Progression, and Pathogenic Mechanisms of Cutaneous Neurofibromas Revealed by Mice with Nf1 Knockout in Boundary Cap Cells

Autor: Jean-Michel Vallat, Katarzyna J .Radomska, Pierre Wolkenstein, Patrick Charnay, Amal Debbiche, Aurélie Gresset, Fanny Coulpier, Sophie Lemoine, Piotr Topilko, Alain Schmitt

Publikováno v: Cancer Discovery
Cancer Discovery, American Association for Cancer Research, In press, 9 (1), pp.130-147. ⟨10.1158/2159-8290.CD-18-0156⟩
Cancer Discovery, In press, 9 (1), pp.130-147. ⟨10.1158/2159-8290.CD-18-0156⟩

Patients carrying an inactive NF1 allele develop tumors of Schwann cell origin called neurofibromas (NF). Genetically engineered mouse models have significantly enriched our understanding of plexiform forms of NFs (pNF). However, this has not been th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfab8e1bc1c83c4c4c78a8a493e30668
https://doi.org/10.1158/2159-8290.cd-18-0156