MiR-20a promotes osteogenic differentiation in bone marrow-derived mesenchymal stem/stromal cells and bone repair of the maxillary sinus defect model in rabbits

Autor: Yi-Xuan Wang, Zhu-Li Peng, Zhi-Wen Sun, Yan-Jun Pan, Hong Ai, Zhi-Hui Mai

Publikováno v: Frontiers in Bioengineering and Biotechnology, Vol 11 (2023)

Introduction: This study aimed to determine whether miR-20 promoted osteogenic differentiation in bone marrow-derived mesenchymal stem/stromal cells (BMSCs) and accelerated bone formation in the maxillary sinus bone defect model in rabbits.Methods: B

Externí odkaz: https://doaj.org/article/b63ad208d81d423f91a8a1c379050fad

NF-κB activation impedes the transdifferentiation of hypertrophic chondrocytes at the growth plate of mouse embryos in diabetic pregnancy

Autor: Xi Liu, Fan Qian, Qiwei Fan, Li Lin, Meiyao He, Peizhi Li, Hongmei Cai, Lisha Ma, Xin Cheng, Xuesong Yang

Publikováno v: Journal of Orthopaedic Translation, Vol 31, Iss , Pp 52-61 (2021)

Background: Diabetes mellitus could cause numerous complications and health problems including abnormality of endochondral bone formation during embryogenesis. However, the underlying mechanisms still remain obscure. Methods: Streptozotoci (STZ) was

Externí odkaz: https://doaj.org/article/c6d424e094e0452ebf705f048e3b92c7

Influences of donor and host age on human muscle-derived stem cell-mediated bone regeneration

Autor: Xueqin Gao, Aiping Lu, Ying Tang, Johannes Schneppendahl, Andrea B. Liebowitz, Alex C. Scibetta, Elizabeth R. Morris, Haizi Cheng, Charles Huard, Sarah Amra, Bing Wang, Mary A. Hall, Walter R. Lowe, Johnny Huard

Publikováno v: Stem Cell Research & Therapy, Vol 9, Iss 1, Pp 1-18 (2018)

Abstract Background Human muscle-derived stem cells (hMDSCs) have been shown to regenerate bone efficiently when they were transduced with Lenti-viral bone morphogenetic protein 2 (LBMP2). However, whether the age of hMDSCs and the animal host affect

Externí odkaz: https://doaj.org/article/8f0630ab8801446dab770466b032643e

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Site-Directed Immobilization of an Engineered Bone Morphogenetic Protein 2 (BMP2) Variant to Collagen-Based Microspheres Induces Bone Formation In Vivo

Autor: Claudia Siverino, Shorouk Fahmy-Garcia, Didem Mumcuoglu, Heike Oberwinkler, Markus Muehlemann, Thomas Mueller, Eric Farrell, Gerjo J. V. M. van Osch, Joachim Nickel

Publikováno v: International Journal of Molecular Sciences; Volume 23; Issue 7; Pages: 3928
International Journal of Molecular Sciences, 23(7):3928. Multidisciplinary Digital Publishing Institute (MDPI)

For the treatment of large bone defects, the commonly used technique of autologous bone grafting presents several drawbacks and limitations. With the discovery of the bone-inducing capabilities of bone morphogenetic protein 2 (BMP2), several delivery

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6522d08ef88a8cd64d3ab95fd52da6b1