Zobrazeno 1 - 10
of 1 281
pro vyhledávání: '"bone biology"'
Autor:
Sunil Wadhwa, Taylor R. Finn, Karolina Kister, Satoko Matsumura, Michael Levit, Anyelina Cantos, Jayesh Shah, Bruno Bohn, Evanthia Lalla, John T. Grbic, Ryan T. Demmer, Michael T. Yin
Publikováno v:
BMC Oral Health, Vol 24, Iss 1, Pp 1-10 (2024)
Abstract Background With effective antiretroviral therapy, people with HIV (PWH) are living longer and aging; the majority of PWH in the United States are now over the age of 50 and in women have gone through the menopause transition. Menopause poten
Externí odkaz:
https://doaj.org/article/26405f31d6ba428d9a9cf1f7f0aebd11
Autor:
Jennifer Zieba, Lisette Nevarez, Davis Wachtell, Jorge H. Martin, Alexander Kot, Sereen Wong, Daniel H. Cohn, Deborah Krakow
Publikováno v:
JCI Insight, Vol 8, Iss 21 (2023)
Osteogenesis imperfecta (OI), or brittle bone disease, is a disorder characterized by bone fragility and increased fracture incidence. All forms of OI also feature short stature, implying an effect on endochondral ossification. Using the Aga2+/– mo
Externí odkaz:
https://doaj.org/article/4946e1029cdd4585be516202cc6f5d0d
Autor:
Elizabeth Hwang-Wong, Gabrielle Amar, Nanditha Das, Xiaoli Zhang, Nina Aaron, Kirsten Gale, Nyanza Rothman, Massimo Fante, Andrew Baik, Ajay Bhargava, Arun Fricker, Michelle McAlister, Jeremy Rabinowitz, John Lees-Shepard, Kalyan Nannuru, Aris N. Economides, Katherine D. Cygnar
Publikováno v:
JCI Insight, Vol 8, Iss 21 (2023)
Mucopolysaccharidosis VI (MPS VI) is a rare lysosomal disease arising from impaired function of the enzyme arylsulfatase B (ARSB). This impairment causes aberrant accumulation of dermatan sulfate, a glycosaminoglycan (GAG) abundant in cartilage. Whil
Externí odkaz:
https://doaj.org/article/d478567e5dad49448a74c8913282750d
Autor:
Yun-Wen Lin, Hsiao-Jung Kao, Wei-Ting Chen, Cheng-Fu Kao, Jer-Yuarn Wu, Yuan-Tsong Chen, Yi-Ching Lee
Publikováno v:
JCI Insight, Vol 8, Iss 22 (2023)
Overactive fibroblast growth factor receptor 3 (FGFR3) signaling drives pathogenesis in a variety of cancers and a spectrum of short-limbed bone dysplasias, including the most common form of human dwarfism, achondroplasia (ACH). Targeting FGFR3 activ
Externí odkaz:
https://doaj.org/article/726be9a941254a5595ff0d4f50e4c86d
Autor:
Kenji Takami, Kazuki Okamoto, Yuki Etani, Makoto Hirao, Akira Miyama, Gensuke Okamura, Atsushi Goshima, Taihei Miura, Takuya Kurihara, Yuji Fukuda, Takashi Kanamoto, Ken Nakata, Seiji Okada, Kosuke Ebina
Publikováno v:
JCI Insight, Vol 8, Iss 22 (2023)
NF-κB is a transcription factor that is activated with aging. It plays a key role in the development of osteoporosis by promoting osteoclast differentiation and inhibiting osteoblast differentiation. In this study, we developed a small anti–NF-κB
Externí odkaz:
https://doaj.org/article/92566f0759554cdeb09b17a795bb8af6
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 19 (2023)
Externí odkaz:
https://doaj.org/article/21158086210f4d4899fa9d8a52c8c541
Autor:
Zhengtao Lv, Jiaming Zhang, Shuang Liang, Chenhe Zhou, Dorothy Hu, Daniel J. Brooks, Mary L. Bouxsein, Beate Lanske, Paul Kostenuik, Francesca Gori, Roland Baron
Publikováno v:
JCI Insight, Vol 8, Iss 20 (2023)
Osteocytes express parathyroid hormone (PTH)/PTH-related protein (PTHrP) receptors and respond to the PTHrP analog abaloparatide (ABL) and to the PTH 1-34 fragment teriparatide (TPTD), which are used to treat osteoporosis. Several studies indicate ov
Externí odkaz:
https://doaj.org/article/1fa370aa0f214e7faf41ab04fe5dc50a
Autor:
Manabu Kawata, Daniel B. McClatchy, Jolene K. Diedrich, Merissa Olmer, Kristen A. Johnson, John R. Yates, Martin K. Lotz
Publikováno v:
JCI Insight, Vol 8, Iss 17 (2023)
Osteoarthritis (OA) is the most common joint disorder, and disease-modifying OA drugs (DMOADs) represent a major need in OA management. Krüppel-like factor 4 (KLF4) is a central transcription factor upregulating regenerative and protective functions
Externí odkaz:
https://doaj.org/article/84f445dd7562469d8561ab051947bdb1
Autor:
Qiang Fu, Nancy C. Bustamante-Gomez, Humberto Reyes-Pardo, Igor Gubrij, Diana Escalona-Vargas, Jeff D. Thostenson, Michela Palmieri, Joseph J. Goellner, Intawat Nookaew, C. Lowry Barnes, Jeffrey B. Stambough, Elena Ambrogini, Charles A. O’Brien
Publikováno v:
JCI Insight, Vol 8, Iss 18 (2023)
Denosumab is an anti-RANKL Ab that potently suppresses bone resorption, increases bone mass, and reduces fracture risk. Discontinuation of denosumab causes rapid rebound bone resorption and bone loss, but the molecular mechanisms are unclear. We gene
Externí odkaz:
https://doaj.org/article/82f9bbc937414ac8a33804dad0b78c04
Publikováno v:
Frontiers in Surgery, Vol 10 (2023)
Externí odkaz:
https://doaj.org/article/52470054472e4ff28448124e4098a462