Inhibition of RANK signaling in breast cancer induces an anti-tumor immune response orchestrated by CD8+ T cells

Autor: Thierry Walzer, Josef M. Penninger, Peter Vuylsteke, Gert Van den Eynden, Bastien Nguyen, Eva González-Suárez, Sherene Loi, Soizic Garaud, C. Velghe, David Venet, Françoise Rothé, Purificación Muñoz, Lourdes Planelles, Enrique Hernández-Jiménez, Philippe Simon, Hans Wildiers, Eva M. Trinidad, Sandra Benítez, Hatem A. Azim, Guillermo Yoldi, Christos Sotiriou, Roberto Salgado, Geoffrey J. Lindeman, Maria Zafeiroglou, Marina Ciscar, Alexandra Barranco, Stefan Michiels, Clara Gómez-Aleza, Martine Piccart, Laura Polastro, Karen Willard-Gallo, Pasquale Pellegrini, Marion Maetens, Denis Larsimont

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
Nature Communications
Nature communications, 11 (1
Repisalud
Instituto de Salud Carlos III (ISCIII)

Most breast cancers exhibit low immune infiltration and are unresponsive to immunotherapy. We hypothesized that inhibition of the receptor activator of nuclear factor-κB (RANK) signaling pathway may enhance immune activation. Here we report that los

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eaab5273f7d1563d1814cb86c4091fe2
https://doaj.org/article/25343e5b801f4662be448798ebe81a76

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Mechanisms for the Antihyperglycemic Effect of Sitagliptin in Patients with Type 2 Diabetes

Autor: Y. Chen, Brenno Astiarraga, Elza Muscelli, A Casolaro, Giuseppe Seghieri, Ele Ferrannini, Amalia Gastaldelli, Jens J. Holst, Andrea Mari, Maria Alba

Publikováno v: The Journal of clinical endocrinology and metabolism 97 (2012): 2818–2826.
info:cnr-pdr/source/autori:Muscelli, E.;Casolaro, A.;Gastaldelli, A.;Mari, A.;Seghieri, G.;Astiarraga, B.;Chen, Y.;Alba, M.;Holst, J.;Ferrannini, E.,/titolo:Mechanisms for the antihyperglycemic effect of sitagliptin in patients with type 2 diabetes/doi:/rivista:The Journal of clinical endocrinology and metabolism/anno:2012/pagina_da:2818/pagina_a:2826/intervallo_pagine:2818–2826/volume:97

Context: Dipeptidyl peptidase IV (DPP-4) inhibitors improve glycemic control in patients with type 2 diabetes. The underlying mechanisms (incretin effect, β-cell function, endogenous glucose production) are not well known. Objective: The aim of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d00bdeaa759ea743ddad63474bcfab79
https://doi.org/10.1210/jc.2012-1205

Predictive value of admission blood glucose level on short-term mortality in acute cerebral ischemia

Autor: Giancarlo Agnelli, Maurizio Paciaroni, Paolo Eusebi, Katiuscia Nardi, Paolo Milia, Valeria Caso

Publikováno v: Journal of Diabetes and its Complications. 26:70-76

Admission hyperglycemia increases the risk of death in patients with acute stroke. However, the most appropriate cut-off of glucose level indicating an increased risk of short-term mortality remains unknown.We aimed at establishing the optimum cut-of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ae419e9a543a2705f45f52dca899563
https://doi.org/10.1016/j.jdiacomp.2012.03.001

Cellular Viral Rebound after Cessation of Potent Antiretroviral Therapy Predicted by Levels of Multiply Spliced HIV-1 RNA Encoding nef

Autor: Marek Fischer, Beda Joos, Gabriela Bleiber, Huldrych F. Günthard, Rainer Weber, Bernard Hirschel

Publikováno v: The Journal of Infectious Diseases, Vol. 190, No 11 (2004) pp. 1979-1988
Journal of Infectious Diseases, vol. 190, no. 11, pp. 1979-1988

To characterize newly arising replication of human immunodeficiency virus (HIV) type 1 in vivo at the cellular level, distinct viral RNA species in peripheral blood mononuclear cells (PBMCs) from HIV-1-infected patients were monitored during 2 weeks

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8795abb5cd62992526c1b008f7d9186
http://doc.rero.ch/record/293571/files/190-11-1979.pdf