The role of streptavidin and its variants in catalysis by biotinylated secondary amines

Autor: Louis C. Morrill, Katarzyna Świderek, Nicolò Santi, Raquel Castillo, Magdalena Lipka-Lloyd, Alexander R. Nödling, Louis Yp Luk, Vicent Moliner, Yi Jin

Publikováno v: Repositori Universitat Jaume I
Universitat Jaume I
Organic & Biomolecular Chemistry
Nödling, A R, Santi, N, Castillo, R, Lipka-Lloyd, M, Jin, Y, Morrill, L C, Świderek, K, Moliner, V & Luk, L Y P 2021, ' The role of streptavidin and its variants in catalysis by biotinylated secondary amines ', Organic & biomolecular chemistry, vol. 19, no. 47, pp. 10424-10431 . https://doi.org/10.1039/d1ob01947c

Here, we combine the use of host screening, protein crystallography and QM/MM molecular dynamics simulations to investigate how the protein structure affects iminium catalysis by biotinylated secondary amines in a model 1,4 conjugate addition reactio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c76ab33f16ee8ab6862ad4600d00010d
https://doi.org/10.1039/D1OB01947C