Posttranslational modification impact on the mechanism by which amyloid-β induces synaptic dysfunction

Autor: Stephan Schilling, Michael R. Kreutz, Julia Bär, Michaela Schweizer, Hans-Ulrich Demuth, PingAn Yuanxiang, Gemma Navarro Brugal, Katarzyna M. Grochowska, Arthur Bikbaev, Rajeev Raman, Giriraj Sahu

Publikováno v: EMBO reports
EMBO reports 18(6), 962-981 (2017). doi:10.15252/embr.201643519

Oligomeric amyloid-β (Aβ) 1-42 disrupts synaptic function at an early stage of Alzheimer's disease (AD). Multiple posttranslational modifications of Aβ have been identified, among which N-terminally truncated forms are the most abundant. It is not

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4959dc10d01783fecc14a64114ea1e46

Leptin activates human B cells to secrete TNF-α, IL-6, and IL-10 via JAK2/STAT3 and p38MAPK/ERK1/2 signaling pathway

Autor: Sastry Gollapudi, Sudhir Gupta, Sudhanshu Agrawal, Houfen Su

Publikováno v: Agrawal, Sudhanshu; Gollapudi, Sastry; Su, Houfen; & Gupta, Sudhir. (2011). Leptin activates human B cells to secrete TNF-α, IL-6, and IL-10 via JAK2/STAT3 and p38MAPK/ERK1/2 signaling pathway.. Journal of clinical immunology, 31(3), 472-478. UC Irvine: Institute for Clinical and Translational Science. Retrieved from: http://www.escholarship.org/uc/item/25g4r67r
Journal of Clinical Immunology

Leptin, one of the adipokines, functions as a hormone and a cytokine. In this investigation, we show for the first time that leptin, in a concentration-dependent manner, activates human peripheral blood B cells to induce secretion of IL-6, IL-10, and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a097d2c5cd3c00b99346293759b11ce
http://www.escholarship.org/uc/item/25g4r67r

Physicochemical and biological analysis of synthetic bacterial lipopeptides: validity of the concept of endotoxic conformation

Autor: Schromm, A. B., Howe, J., Ulmer, A. J., Wiesmüller, K. H., Seyberth, T., Jung, G., Rössle, M., Koch, M. H. J., Gutsmann, T., Brandenburg, K.

Publikováno v: The journal of biological chemistry 282, 11030-11037 (2007). doi:10.1074/jbc.M700287200

The importance of the biological function and activity of lipoproteins from the outer or cytoplasmic membranes of Gram-positive and Gram-negative bacteria is being increasingly recognized. It is well established that they are like the endotoxins (lip

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::86a53e1c64e4fbd25172ba175f28ac1f
https://pubmed.ncbi.nlm.nih.gov/17308304