Novel regulators of PrPC biosynthesis revealed by genome-wide RNA interference

Autor: Simon Mead, Simone Hornemann, Marc Emmenegger, Elke Schaper, Kevin Maggi, Peter Heutink, Jiang-An Yin, Anna Spinelli, Ashutosh Dhingra, Daniel Heinzer, Berre Doğançay, Merve Avar, Daniel Patrick Pease, Adriano Aguzzi, Andra Chincisan

Publikováno v: PLoS Pathogens, Vol 17, Iss 10 (2021)
PLoS pathogens 17(10), e1010013 (2021). doi:10.1371/journal.ppat.1010013
PLoS Pathogens, Vol 17, Iss 10, p e1010013 (2021)
PLoS Pathogens

The cellular prion protein PrPC is necessary for prion replication, and its reduction greatly increases life expectancy in animal models of prion infection. Hence the factors controlling the levels of PrPC may represent therapeutic targets against hu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59f070e22194fd9e3258e126ce44b9be
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8575309/?tool=EBI