Phosphorylation of muramyl peptides by NAGK is required for NOD2 activation

Autor: Che A. Stafford, Alicia-Marie Gassauer, Carina C. de Oliveira Mann, Maria C. Tanzer, Evelyn Fessler, Benedikt Wefers, Dennis Nagl, Gunnar Kuut, Karolina Sulek, Catherine Vasilopoulou, Sophia J. Schwojer, Andreas Wiest, Marie K. Pfautsch, Wolfgang Wurst, Monica Yabal, Thomas Fröhlich, Matthias Mann, Nicolas Gisch, Lucas T. Jae, Veit Hornung

Publikováno v: Stafford, C A, Gassauer, A M, de Oliveira Mann, C C, Tanzer, M C, Fessler, E, Wefers, B, Nagl, D, Kuut, G, Sulek, K, Vasilopoulou, C, Schwojer, S J, Wiest, A, Pfautsch, M K, Wurst, W, Yabal, M, Fröhlich, T, Mann, M, Gisch, N, Jae, L T & Hornung, V 2022, ' Phosphorylation of muramyl peptides by NAGK is required for NOD2 activation ', Nature, vol. 609, pp. 590-596 . https://doi.org/10.1038/s41586-022-05125-x
Nature
Nature 609, 590-596 (2022)
Nature 609(7927), 590-596 (2022). doi:10.1038/s41586-022-05125-x

Bacterial cell wall components provide various unique molecular structures that are detected by pattern recognition receptors (PRRs) of the innate immune system as non-self. Most bacterial species form a cell wall that consists of peptidoglycan (PGN)

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