Zobrazeno 1 - 10
of 90
pro vyhledávání: '"biomimetic chromatography"'
Autor:
E. Grządka, I. Malinowska
Publikováno v:
Applied Sciences, Vol 14, Iss 10, p 4265 (2024)
This paper presents various aspects of the use of chromatography to determine the biological activity of substances. On the one hand, the use of chromatography to determine the lipophilicity of a substance, a property that affects all LADME steps in
Externí odkaz:
https://doaj.org/article/1af0b53514b8466b8c65401f5fdf67bd
Akademický článek
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Publikováno v:
Pharmaceutics, Vol 15, Iss 4, p 1172 (2023)
Chromatographic retention data collected on immobilized keratin (KER) or immobilized artificial membrane (IAM) stationary phases were used to predict skin permeability coefficient (log Kp) and bioconcentration factor (log BCF) of structurally unrelat
Externí odkaz:
https://doaj.org/article/f8494ceed3b14c55bb23db8a5ce0db00
Publikováno v:
Pharmaceuticals, Vol 15, Iss 8, p 965 (2022)
In the present study, various procedures have been compared for the determination of lipophilicity, hydrophobicity, and plasma protein binding of curcuminoids, boswellic acids, andrographolides, and piperine as biologically active ingredients of bota
Externí odkaz:
https://doaj.org/article/ef4544cfeedb499fa1196073b9e3a605
Publikováno v:
Molecules, Vol 27, Iss 12, p 3668 (2022)
The development of high-throughput approaches for the valid estimation of brain disposition is of great importance in the early drug screening of drug candidates. However, the complexity of brain tissue, which is protected by a unique vasculature for
Externí odkaz:
https://doaj.org/article/65a59db46d5f4dd89a1c58e04873fbe1
Akademický článek
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Akademický článek
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Autor:
Shenaz Bunnally, Rob J Young
Publikováno v:
ADMET and DMPK, Vol 6, Iss 2, Pp 74-84 (2018)
During the early phase of drug discovery, it is becoming increasingly important to acquire the full physicochemical profile of molecules. For this purpose, there is a strong interest in developing efficient and cost-effective platforms for fast and r
Externí odkaz:
https://doaj.org/article/ee2d31fa3e4a412088396a66e641328d
Autor:
Annita Katopodi, Evangelia Tsotsou, Triantafylia Iliou, Georgia-Eirini Deligiannidou, Eleni Pontiki, Christos Kontogiorgis, Fotios Tsopelas, Anastasia Detsi
Publikováno v:
Molecules, Vol 26, Iss 19, p 5999 (2021)
A series of novel multi-substituted coumarin derivatives were synthesized, spectroscopically characterized, and evaluated for their antioxidant activity, soybean lipoxygenase (LOX) inhibitory ability, their influence on cell viability in immortalized
Externí odkaz:
https://doaj.org/article/5cc935ce33a14700a5ce386e826f0fd4
Autor:
Klara Livia Valko
Publikováno v:
ADMET and DMPK, Vol 6, Iss 2, Pp 71-73 (2018)
The drug discovery process usually involves the discovery of a potent new chemical entity which has shown some activity on a target that is believed to be relevant in a certain type of disease. However, the structure and property of these putative dr
Externí odkaz:
https://doaj.org/article/36b84f8ba67b47ae9b7a8aca415debd6