Considerations of growth factor and material use in bone tissue engineering using biodegradable scaffolds in vitro and in vivo

Autor: Karen M. Marshall, Jonathan P. Wojciechowski, Vineetha Jayawarna, Abshar Hasan, Cécile Echalier, Øystein Øvrebø, Tao Yang, Kun Zhou, Janos M. Kanczler, Alvaro Mata, Manuel Salmeron-Sanchez, Molly M. Stevens, Richard O. C. Oreffo

Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-18 (2024)

Abstract Bone tissue engineering aims to harness materials to develop functional bone tissue to heal ‘critical-sized’ bone defects. This study examined a robust, coated poly(caprolactone) trimethacrylate (PCL-TMA) 3D-printable scaffold designed t

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Considerations of growth factor and material use in bone tissue engineering using biodegradable scaffolds in vitro and in vivo.

Autor: Marshall KM; Bone and Joint Research Group, Centre for Human Development, Stem Cells and Regeneration, Institute of Developmental Sciences, University of Southampton, Southampton, SO16 6YD, United Kingdom. K.M.Marshall@soton.ac.uk., Wojciechowski JP; Department of Materials, Department of Bioengineering and Institute for Biomedical Engineering, Imperial College London, London, SW7 2AZ, United Kingdom.; Kavli Institute for Nanoscience Discovery, Department of Physiology, Anatomy and Genetics, Department of Engineering Science, University of Oxford, Oxford, OX1 3QU, United Kingdom., Jayawarna V; School of Engineering, Centre for the Cellular Microenvironment, Advanced Research Centre, University of Glasgow, Glasgow, G11 6EW, United Kingdom., Hasan A; School of Pharmacy, University of Nottingham, Nottingham, NG7 2RD, United Kingdom., Echalier C; Department of Materials, Department of Bioengineering and Institute for Biomedical Engineering, Imperial College London, London, SW7 2AZ, United Kingdom., Øvrebø Ø; Department of Materials, Department of Bioengineering and Institute for Biomedical Engineering, Imperial College London, London, SW7 2AZ, United Kingdom., Yang T; Department of Materials, Department of Bioengineering and Institute for Biomedical Engineering, Imperial College London, London, SW7 2AZ, United Kingdom.; Kavli Institute for Nanoscience Discovery, Department of Physiology, Anatomy and Genetics, Department of Engineering Science, University of Oxford, Oxford, OX1 3QU, United Kingdom., Zhou K; Department of Materials, Department of Bioengineering and Institute for Biomedical Engineering, Imperial College London, London, SW7 2AZ, United Kingdom., Kanczler JM; Bone and Joint Research Group, Centre for Human Development, Stem Cells and Regeneration, Institute of Developmental Sciences, University of Southampton, Southampton, SO16 6YD, United Kingdom., Mata A; School of Pharmacy, University of Nottingham, Nottingham, NG7 2RD, United Kingdom.; Department of Chemical and Environmental Engineering and NIHR Nottingham Biomedical Research Centre, University of Nottingham, Nottingham, NG7 2RD, United Kingdom., Salmeron-Sanchez M; School of Engineering, Centre for the Cellular Microenvironment, Advanced Research Centre, University of Glasgow, Glasgow, G11 6EW, United Kingdom., Stevens MM; Department of Materials, Department of Bioengineering and Institute for Biomedical Engineering, Imperial College London, London, SW7 2AZ, United Kingdom.; Kavli Institute for Nanoscience Discovery, Department of Physiology, Anatomy and Genetics, Department of Engineering Science, University of Oxford, Oxford, OX1 3QU, United Kingdom., Oreffo ROC; Bone and Joint Research Group, Centre for Human Development, Stem Cells and Regeneration, Institute of Developmental Sciences, University of Southampton, Southampton, SO16 6YD, United Kingdom. Richard.Oreffo@soton.ac.uk.

Publikováno v: Scientific reports [Sci Rep] 2024 Oct 28; Vol. 14 (1), pp. 25832. Date of Electronic Publication: 2024 Oct 28.