Zobrazeno 1 - 10
of 2 471
pro vyhledávání: '"binding mode"'
Autor:
Meng WEI, Wenna ZHANG, Aiyun HAN, Libin XIE, Xiaochang LIU, Songshan ZHANG, Peng XIE, Baozhong SUN
Publikováno v:
Shipin gongye ke-ji, Vol 45, Iss 20, Pp 390-397 (2024)
Flavor significantly influences the quality of meat and meat products. The dynamic equilibrium between the release and retention of volatile flavor compounds, influenced by the interaction of muscle proteins and flavor compounds, is crucial in determ
Externí odkaz:
https://doaj.org/article/acbefaa24b884b6a8e1210a0f0420754
Publikováno v:
Food Frontiers, Vol 5, Iss 4, Pp 1613-1628 (2024)
Abstract Polysaccharides are widely used as quality improvers for meat products. However, the mechanisms of how different ionic polysaccharides regulate the gelling properties of myofibrillar protein (MP) are still unclear. This study aimed to elucid
Externí odkaz:
https://doaj.org/article/ef1638cd9b99424bb42b030b5a1a38ae
Autor:
Meiting Wang, Baoyi Fan, Wenfeng Lu, Ulf Ryde, Yuxiao Chang, Di Han, Jiarui Lu, Taigang Liu, Qinghe Gao, Changpo Chen, Yongtao Xu
Publikováno v:
Molecules, Vol 29, Iss 11, p 2650 (2024)
The stimulator of interferon genes (STING) plays a significant role in immune defense and protection against tumor proliferation. Many cyclic dinucleotide (CDN) analogues have been reported to regulate its activity, but the dynamic process involved w
Externí odkaz:
https://doaj.org/article/34ab4fa9d31e49c79ffe6ecc49b31d38
Publikováno v:
Exploration of Targeted Anti-tumor Therapy, Vol 4, Iss 3, Pp 447-459 (2023)
Aim: Human histone deacetylase 8 (KDAC8) is a well-recognized pharmaceutical target in Cornelia de Lange syndrome and different types of cancer, particularly childhood neuroblastoma. Several classes of chemotypes have been identified, which interfere
Externí odkaz:
https://doaj.org/article/09054771e1f548cf970cf8f87978e73c
Publikováno v:
Phytopathology Research, Vol 5, Iss 1, Pp 1-13 (2023)
Abstract Gray mold, caused by Botrytis cinerea, poses a significant threat to the strawberry industry worldwide. B. cinerea is a high-risk pathogen in the sense of fungicide resistance. The sensitivities of B. cinerea isolates collected from Zhejiang
Externí odkaz:
https://doaj.org/article/47b5bec7e282498696a8be2f69df4468
Publikováno v:
Pharmaceuticals, Vol 17, Iss 4, p 445 (2024)
Cytarabine (Ara-C) is a synthetic isomer of cytidine that differs from cytidine and deoxycytidine only in the sugar. The use of arabinose instead of deoxyribose hinders the formation of phosphodiester linkages between pentoses, preventing the DNA cha
Externí odkaz:
https://doaj.org/article/12d93809c9c345c39558a742bb228470
Autor:
Sina B Kirchhofer, Victor Jun Yu Lim, Sebastian Ernst, Noemi Karsai, Julia G Ruland, Meritxell Canals, Peter Kolb, Moritz Bünemann
Publikováno v:
eLife, Vol 12 (2023)
The µ opioid receptor (MOR) is the key target for analgesia, but the application of opioids is accompanied by several issues. There is a wide range of opioid analgesics, differing in their chemical structure and their properties of receptor activati
Externí odkaz:
https://doaj.org/article/d5eb377bbd5c46ab8998c51de514679a
Autor:
Jin Dong, Jiangqing Dong, Xin-He Yu, Yao-Chao Yan, Jia-Xu Nan, Bo He, Bao-Qin Ye, Wen-Chao Yang, Hong-Yan Lin, Guang-Fu Yang
Publikováno v:
Advanced Agrochem, Vol 1, Iss 2, Pp 174-181 (2022)
4-Hydrophenylpyruvate dioxygenase (HPPD), a key enzyme involved in tyrosine catabolism, has long been considered a promising target for herbicides and drugs. Several types of HPPD inhibitors have been developed as high-potency drugs or herbicides. Un
Externí odkaz:
https://doaj.org/article/9aa7e6bc183c4c999e703ceb994a0772
Publikováno v:
BMC Bioinformatics, Vol 23, Iss 1, Pp 1-18 (2022)
Abstract Protein ligand docking is an indispensable tool for computational prediction of protein functions and screening drug candidates. Despite significant progress over the past two decades, it is still a challenging problem, characterized by the
Externí odkaz:
https://doaj.org/article/7727630e494348689ff8c9280a7334a5
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