Zobrazeno 1 - 10
of 246
pro vyhledávání: '"binding free energy calculations"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)
Abstract Cytosolic Glycerol-3-phosphate dehydrogenase 1 (GPD1, EC 1.1.1.8) plays a pivotal role in regulating the Embden-Meyerhof glucose glycolysis pathway (E-M pathway), as well as in conditions such as Huntington’s disease, cancer, and its poten
Externí odkaz:
https://doaj.org/article/1d748ee1fa5c43fdb0fcf4a717862acd
Publikováno v:
Pharmaceuticals, Vol 17, Iss 9, p 1120 (2024)
Sirtuin 2 (SIRT2), an NAD+-dependent deacetylase, is crucial for regulating vital physiological processes, including aging, DNA repair, and cell cycle progression. Its abnormal activity is linked to diseases such as Parkinson’s disease, cancer, and
Externí odkaz:
https://doaj.org/article/13180136154d4c62b7d50fe26155000d
Autor:
Guodong Zheng, Wuxia Liu, Qian Zhang, Tuo Shen, Jingfeng Zhang, Lei Jiang, Wenqi Liang, Bin Zhou, Ling Liu, Shenqian Xu, Minyu Li
Publikováno v:
Journal of Experimental Nanoscience, Vol 18, Iss 1 (2023)
AbstractFibroblast growth factor receptor 2 (FGFR2), as a transmembrane receptor tyrosine kinase, is implicated in a plethora of human cancers, including intrahepatic cholangiocarcinomas, breast cancers, and non-small cell lung cancer. The clinically
Externí odkaz:
https://doaj.org/article/6bed2bc269794760a0a344ce58593f64
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
da Costa Renato A., da Rocha João A.P., Pinheiro Alan S., da Costa Andréia S.S., da Rocha Elaine C.M., Josino Luiz P.C., da Gonçalves Arlan Silva, Lima Anderson H.L., Brasil Davi S.B.
Publikováno v:
Journal of the Serbian Chemical Society, Vol 87, Iss 6, Pp 693-706 (2022)
Although dengue is a disease that affects more than 100 countries and puts almost 400 million lives at risk each year, there is no approved antiviral in the treatment of this pathology. In this context, proteases are potential biological targets sinc
Externí odkaz:
https://doaj.org/article/2bae6882104741d98a6659b2f811e46a
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Publikováno v:
Molecules, Vol 28, Iss 14, p 5315 (2023)
As one of the crucial targets of epigenetics, histone lysine-specific demethylase 1 (LSD1) is significant in the occurrence and development of various tumors. Although several irreversible covalent LSD1 inhibitors have entered clinical trials, the la
Externí odkaz:
https://doaj.org/article/1a8dcd416c704fceacc723e93d73cfa1
Autor:
Emma Langella, Davide Esposito, Simona Maria Monti, Claudiu T. Supuran, Giuseppina De Simone, Vincenzo Alterio
Publikováno v:
Biology, Vol 12, Iss 2, p 281 (2023)
Aliphatic sulfonamides are an interesting class of carbonic anhydrase inhibitors (CAIs) proven to be effective for several carbonic anhydrase (CA) isoforms involved in pathologic states. Here we report the crystallographic structures of hCA II in com
Externí odkaz:
https://doaj.org/article/2b643e7e8bfd430c9ff810c7bbb70555
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 19, p 11838 (2022)
Xyloglucan endotransglycosylases (XETs) play key roles in the remodelling and reconstruction of plant cell walls. These enzymes catalyse homo-transglycosylation reactions with xyloglucan-derived donor and acceptor substrates and hetero-transglycosyla
Externí odkaz:
https://doaj.org/article/d3c491f8b14c49539a59953b6e6bacf2