Delineation of molecular changes in intrahepatic cholesterol metabolism resulting from diminished cholesterol absorption

Autor: Joyce J. Repa, Stephen D. Turley, Gang Quan, John M. Dietschy

Publikováno v: Journal of Lipid Research, Vol 46, Iss 4, Pp 779-789 (2005)

The absorption of cholesterol by the small intestine is a major route for the net entry of cholesterol into the body and can therefore affect the plasma low density lipoprotein-cholesterol (LDL-C) concentration. These studies used ezetimibe, a potent

Externí odkaz: https://doaj.org/article/5d7ba2b2b52a401e873ca841d7d6bc9f

Persistent fat malabsorption in cystic fibrosis; lessons from patients and mice

Autor: Frank A J A Bodewes, Henkjan J. Verkade, Marjan Wouthuyzen-Bakker

Publikováno v: Journal of Cystic Fibrosis. 10(3):150-158

Fat malabsorption in pancreatic insufficient cystic fibrosis (CF) patients is classically treated with pancreatic enzyme replacement therapy (PERT). Despite PERT, intestinal fat absorption remains insufficient in most CF patients. Several factors hav

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e613d0fb04783541a4b9880c1ecb008
https://hdl.handle.net/11370/130c42ce-d369-413a-8ef5-4be21f249e32

Fish oil increases bile acid synthesis in male patients with hypertriglyceridemia

Publikováno v: The Journal of Nutrition. 136(4):987-991

Fibrates are drugs of choice in patients with hypertriglyceridemia (HTG), but may increase the risk for gallstones by decreasing bile acid synthesis. Fish oil might be a therapeutic alternative, but its effect on bile acid metabolism in humans is unk

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dris___00893::e50c31443dacc0ee707b6fd5966552ad
http://jn.nutrition.org/content/136/4/987.full

Bile salts induce long polar fimbriae expression favouring Crohn's disease-associated adherent-invasive Escherichia coli interaction with Peyer's patches

Autor: Chassaing, Benoit, Etienne-Mesmin, Lucie, Bonnet, Richard, Darfeuille-Michaud, Arlette

Publikováno v: Environmental Microbiology
Environmental Microbiology, Society for Applied Microbiology and Wiley-Blackwell, 2013, 15 (2), pp.355-371. ⟨10.1111/j.1462-2920.2012.02824.x⟩
Environmental Microbiology, 2013, 15 (2), pp.355-371. ⟨10.1111/j.1462-2920.2012.02824.x⟩

International audience; Ileal lesions of patients with Crohn's disease are colonized by adherent-invasive Escherichia coli (AIEC). The earliest lesions of recurrent Crohn's disease are erosions of Peyer's patches (PP). We recently reported the presen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::4e42d8e0c3f541e84f1cbf489090530b
https://hal.inrae.fr/hal-02646043

Gelucire 44/14 improves fat absorption in rats with impaired lipolysis

Autor: Frans Stellaard, Henkjan J. Verkade, Karin E. R. Gooijert, G. Shlieout, E. H. H. M. Rings, P. C. Gregory, Sabina Lukovac

Publikováno v: Biochimica et biophysica acta-Molecular and cell biology of lipids, 1801(6), 665-673. ELSEVIER SCIENCE BV

Clinically relevant fat malabsorption is usually due to impaired intestinal fat digestion (lipolysis) and/or to impaired solubilization of the lipolytic metabolites. We hypothesized that Gelucire 44/14 - a semi-solid self-micro-emulsifying excipient

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94479e932ea9a68f8dc3cc515d1e9e0c
https://pubmed.ncbi.nlm.nih.gov/20298808