Point mutations affecting yeast prion propagation change the structure of its amyloid fibrils

Autor: Mikhail V. Belousov, Irina M. Kuznetsova, Nina P. Trubitsina, Anna I. Sulatskaya, Galina A. Zhouravleva, Maksim I. Sulatsky, Konstantin K. Turoverov, Manuel A. Llanos, Stanislav A. Bondarev, Andrey V. Kajava

Publikováno v: Journal of Molecular Liquids
Journal of Molecular Liquids, Elsevier, 2020, 314, pp.113618. ⟨10.1016/j.molliq.2020.113618⟩
SEDICI (UNLP)
Universidad Nacional de La Plata
instacron:UNLP

We investigated the effect of the point substitutions in the N-terminal domain of the yeast prion protein Sup35 (Sup35NMp) on the structure of its amyloid fibrils. As the objects of the study, proteins with mutations that have different influence on

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1efef5b42e593965472eb28d8ce04d82
https://doi.org/10.1016/j.molliq.2020.113618

Prediction and Evaluation of Protein Aggregation with Computational Methods.

Autor: Hassan M; The Steve and Cindy Rasmussen Institute for Genomic Medicine, Nationwide Children's Hospital, Columbus, OH, USA. Mubasher.Hassan@nationwidechildrens.org., Shahzadi S; The Steve and Cindy Rasmussen Institute for Genomic Medicine, Nationwide Children's Hospital, Columbus, OH, USA., Li MS; Institute of Physics, Polish Academy of Sciences, Warsaw, Poland., Kloczkowski A; The Steve and Cindy Rasmussen Institute for Genomic Medicine, Nationwide Children's Hospital, Columbus, OH, USA. Andrzej.Kloczkowski@nationwidechildrens.org.; Department of Pediatrics, The Ohio State University, Columbus, OH, USA. Andrzej.Kloczkowski@nationwidechildrens.org.; Department of Biomedical Informatics, The Ohio State University, Columbus, OH, USA. Andrzej.Kloczkowski@nationwidechildrens.org.

Publikováno v: Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2025; Vol. 2867, pp. 299-314.

From Prions to Stress Granules: Defining the Compositional Features of Prion-Like Domains That Promote Different Types of Assemblies.

Autor: Fomicheva, Anastasia¹ (AUTHOR) Anastasia.Fomicheva@colostate.edu, Ross, Eric D.¹ (AUTHOR) eric.ross@colostate.edu, Sahara, Naruhiko (AUTHOR)

Publikováno v: International Journal of Molecular Sciences. Feb2021, Vol. 22 Issue 3, p1251-1251. 1p.

Bioinformatics Methods in Predicting Amyloid Propensity of Peptides and Proteins.

Autor: Kotulska M; Department of Biomedical Engineering, Wroclaw University of Science and Technology, 50-370 Wroclaw, Poland. malgorzata.kotulska@pwr.edu.pl., Wojciechowski JW; Department of Biomedical Engineering, Wroclaw University of Science and Technology, 50-370 Wroclaw, Poland.

Publikováno v: Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2022; Vol. 2340, pp. 1-15.

Structure-based machine-guided mapping of amyloid sequence space reveals uncharted sequence clusters with higher solubilities.

Autor: Louros N; Switch Laboratory, VIB Center for Brain and Disease Research, Herestraat 49, 3000, Leuven, Belgium.; Switch Laboratory, Department of Cellular and Molecular Medicine, KU Leuven, Herestraat 49, 3000, Leuven, Belgium., Orlando G; Switch Laboratory, VIB Center for Brain and Disease Research, Herestraat 49, 3000, Leuven, Belgium.; Switch Laboratory, Department of Cellular and Molecular Medicine, KU Leuven, Herestraat 49, 3000, Leuven, Belgium., De Vleeschouwer M; Switch Laboratory, VIB Center for Brain and Disease Research, Herestraat 49, 3000, Leuven, Belgium.; Switch Laboratory, Department of Cellular and Molecular Medicine, KU Leuven, Herestraat 49, 3000, Leuven, Belgium., Rousseau F; Switch Laboratory, VIB Center for Brain and Disease Research, Herestraat 49, 3000, Leuven, Belgium. Frederic.Rousseau@kuleuven.vib.be.; Switch Laboratory, Department of Cellular and Molecular Medicine, KU Leuven, Herestraat 49, 3000, Leuven, Belgium. Frederic.Rousseau@kuleuven.vib.be., Schymkowitz J; Switch Laboratory, VIB Center for Brain and Disease Research, Herestraat 49, 3000, Leuven, Belgium. Joost.Schymkowitz@kuleuven.vib.be.; Switch Laboratory, Department of Cellular and Molecular Medicine, KU Leuven, Herestraat 49, 3000, Leuven, Belgium. Joost.Schymkowitz@kuleuven.vib.be.

Publikováno v: Nature communications [Nat Commun] 2020 Jul 03; Vol. 11 (1), pp. 3314. Date of Electronic Publication: 2020 Jul 03.