Zobrazeno 1 - 10
of 119
pro vyhledávání: '"beta cell imaging"'
Publikováno v:
Frontiers in Endocrinology, Vol 12 (2021)
Pancreatic beta (β)-cell dysfunction and reduced mass play a central role in the development and progression of diabetes mellitus. Conventional histological β-cell mass (BCM) analysis is invasive and limited to cross-sectional observations in a res
Externí odkaz:
https://doaj.org/article/abaa4ad68d5a4e3993ae2eca75a4b282
Autor:
Mahabuba Jahan, Peter Johnström, Ram K. Selvaraju, Marie Svedberg, Maria Sörhede Winzell, Jenny Bernström, Lee Kingston, Magnus Schou, Zhisheng Jia, Stanko Skrtic, Lars Johansson, Olle Korsgren, Lars Farde, Christer Halldin, Olof Eriksson
Publikováno v:
EJNMMI Research, Vol 8, Iss 1, Pp 1-14 (2018)
Abstract Background The G-protein-coupled receptor 44 (GPR44) is a beta cell-restricted target that may serve as a marker for beta cell mass (BCM) given the development of a suitable PET ligand. Methods The binding characteristics of the selected can
Externí odkaz:
https://doaj.org/article/adeebd397411476c89f34e68e0105f08
Autor:
Mark H. Dornan, Daniil Petrenyov, José-Mathieu Simard, Antonio Aliaga, Guoming Xiong, Julien Ghislain, Barry Bedell, Vincent Poitout, Jean N. DaSilva
Publikováno v:
EJNMMI Radiopharmacy and Chemistry, Vol 3, Iss 1, Pp 1-15 (2018)
Abstract Background The free-fatty acid receptor-1 (FFA-1) is expressed by β-cells and is a promising target for molecular imaging of functional β-cell mass. Recently, the ((3-[18F]fluoropropyl)sulfonyl)propoxy-derivative of the high-affinity FFA-1
Externí odkaz:
https://doaj.org/article/c7921ef1b9984e53b76aa893df52a43c
Akademický článek
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Publikováno v:
Journal of Lipid Research, Vol 52, Iss 9, Pp 1660-1671 (2011)
To devise successful imaging and therapeutic strategies, the identification of β-cell surface markers is one of the challenges in diabetes research that has to be resolved. We previously showed that IC2, a rat monoclonal IgM antibody, can be used fo
Externí odkaz:
https://doaj.org/article/20a5a9f6b028407d9c07c5507ca9a756
Autor:
Stéphane Demine, Alexander Balhuizen, Vinciane Debaille, Lieke Joosten, Maïté Fereau, Satya Narayana Murthy Chilla, Isabelle Millard, Raphaël Scharfmann, Dominique Egrise, Serge Goldman, Piero Marchetti, Martin Gotthardt, Sophie Laurent, Carmen Burtea, Decio L. Eizirik
Publikováno v:
Molecules, Vol 23, Iss 9, p 2100 (2018)
Non-invasive imaging and quantification of human beta cell mass remains a major challenge. We performed pre-clinical in vivo validation of a peptide previously discovered by our group, namely, P88 that targets a beta cell specific biomarker, FXYD2γa
Externí odkaz:
https://doaj.org/article/a15b205aba0e499cad4ae8b7004e0280
Publikováno v:
International journal of molecular sciences, 21 (19
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 21, Iss 7274, p 7274 (2020)
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 21, Iss 7274, p 7274 (2020)
There are presently no reliable ways to quantify human pancreatic beta cell mass (BCM) in vivo, which prevents an accurate understanding of the progressive beta cell loss in diabetes or following islet transplantation. Furthermore, the lack of beta c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::695ed1e232bd28c1c47e631f34d8bd2a
http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/313907
http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/313907
Publikováno v:
Frontiers in Endocrinology, Vol 12 (2021)
Frontiers in Endocrinology
Frontiers in Endocrinology
Pancreatic beta (β)-cell dysfunction and reduced mass play a central role in the development and progression of diabetes mellitus. Conventional histological β-cell mass (BCM) analysis is invasive and limited to cross-sectional observations in a res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82e4711795197496dcafa2cce2c8b4eb
https://www.frontiersin.org/articles/10.3389/fendo.2021.714348/full
https://www.frontiersin.org/articles/10.3389/fendo.2021.714348/full
Autor:
Shiuhwei Chen, ZhiJiang Huang, Harrison Kidd, Min Kim, Eul Hyun Suh, Shangkui Xie, Ebrahim H. Ghazvini Zadeh, Yan Xu, A. Dean Sherry, Philipp E. Scherer, Wen-hong Li
Publikováno v:
Frontiers in Endocrinology
Frontiers in Endocrinology, Vol 12 (2021)
Frontiers in Endocrinology, Vol 12 (2021)
Appropriate insulin secretion is essential for maintaining euglycemia, and impairment or loss of insulin release represents a causal event leading to diabetes. There have been extensive efforts of studying insulin secretion and its regulation using a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a621c009f5a9e00e96175d305d7e91ef
http://europepmc.org/articles/PMC7985533
http://europepmc.org/articles/PMC7985533
Autor:
Jahan, Mahabuba, Johnström, Peter, Selvaraju, Ram K., Svedberg, Marie, Winzell, Maria Sörhede, Bernström, Jenny, Kingston, Lee, Schou, Magnus, Jia, Zhisheng, Skrtic, Stanko, Johansson, Lars, Korsgren, Olle, Farde, Lars, Halldin, Christer, Eriksson, Olof
Publikováno v:
EJNMMI Research
EJNMMI Research, Vol 8, Iss 1, Pp 1-14 (2018)
EJNMMI Research, Vol 8, Iss 1, Pp 1-14 (2018)
Background: The G-protein-coupled receptor 44 (GPR44) is a beta cell-restricted target that may serve as a marker for beta cell mass (BCM) given the development of a suitable PET ligand. Methods: The binding characteristics of the selected candidate,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::96ae9484f343cd49d1f12776819ed41f
http://europepmc.org/articles/PMC6306373
http://europepmc.org/articles/PMC6306373