Výsledky vyhledávání - "beta amyloids"

Akademický článek

Dual response of BDNF to sublethal concentrations of β-amyloid peptides in cultured cortical neurons

Autor: E. Aliaga, M. Silhol, N. Bonneau, T. Maurice, S. Arancibia, L. Tapia-Arancibia

Publikováno v: Neurobiology of Disease, Vol 37, Iss 1, Pp 208-217 (2010)

Beta-amyloid (Aβ) deposition is one important pathological hallmark in Alzheimer's disease (AD). However, low levels of Aβ may modify critical endogenous protection systems before neurodegeneration occurs. We examined the time-course effect of subl

Externí odkaz: https://doaj.org/article/ed57b260f8af4dd1beabc404802457fd

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Akademický článek

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Akademický článek

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Multicomponent, fragment-based synthesis of polyphenol-containing peptidomimetics and their inhibiting activity on beta-amyloid oligomerization

Autor: Denise Galante, Alessia Traverso, Giulio Gancia, Luca Banfi, Cristina D'Arrigo, Renata Riva, Lisa Moni, Chiara Lambruschini, Francesco Ferraro

Publikováno v: Organic & biomolecular chemistry 15 (2017): 9331–9351. doi:10.1039/c7ob02182h
info:cnr-pdr/source/autori:Lambruschini, Chiara; Galante, Denise; Moni, Lisa; Ferraro, Francesco; Gancia, Giulio; Riva, Renata; Traverso, Alessia; Banfi, Luca; D'Arrigo, Cristina/titolo:Multicomponent, fragment-based synthesis of polyphenol-containing peptidomimetics and their inhibiting activity on beta-amyloid oligomerization/doi:10.1039%2Fc7ob02182h/rivista:Organic & biomolecular chemistry/anno:2017/pagina_da:9331/pagina_a:9351/intervallo_pagine:9331–9351/volume:15

A new and short fragment-based approach towards artificial (but "natural-based") complex polyphenols has been developed, exploiting the Ugi multicomponent reaction of phenol-containing simple substrates. The resulting library of compounds has been te

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c0a5fe35ba188eb574cc36d65f14c5e
http://www.cnr.it/prodotto/i/381783

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A critical concentration of N-terminal pyroglutamylated amyloid beta drives the misfolding of Ab1-42 into more toxic aggregates

Autor: Alessandro Corsaro, Francesca Pellistri, Tullio Florio, Elena Gatta, Denise Galante, Giovanni Dietler, Cristina D'Arrigo, Francesco Simone Ruggeri, Angelo Perico

Publikováno v: International Journal of Biochemistry and Cell Biology, 79, 261-270
International Journal of Biochemistry and Cell Biology 79 (2016)

A wide consensus based on robust experimental evidence indicates pyroglutamylated amyloid-beta isoform (A beta pE3-42) as one of the most neurotoxic peptides involved in the onset of Alzheimer's disease. Furthermore, A beta pE3-42 co-oligomerized wit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f429c23f4a1ab0f7feb428384cb829fa
https://research.wur.nl/en/publications/a-critical-concentration-of-n-terminal-pyroglutamylated-amyloid-b

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PYROGLUTAMYLATED AMYLOID-beta AFFECTS THE STRUCTURE, MORPHOLOGY AND TOXICITY OF THE FULL LENGTH BY SMALL QUANTITIES

Autor: Galante Denise, Ruggeri F.S., Pellistri Francesca, Elena Gatta, Tullio Florio, Angelo Perico, Simona Tomaselli, Cristina D'Arrigo

Publikováno v: The 12th international conference on Alzheimer's&Parkinson's diseases AD/PD2015, Nizza, 18-22/03/2015
info:cnr-pdr/source/autori:Galante Denise, Ruggeri F.S., Pellistri Francesca, Elena Gatta, Tullio Florio, Angelo Perico, Simona Tomaselli, Cristina D'Arrigo/congresso_nome:The 12th international conference on Alzheimer's&Parkinson's diseases AD%2FPD2015/congresso_luogo:Nizza/congresso_data:18-22%2F03%2F2015/anno:2015/pagina_da:/pagina_a:/intervallo_pagine

Objectives: to determine which is the ratio in the mixture of A?py3-42 and A?1-42, where A?py3-42 has the major influence on the aggregation kinetics, secondary structure, morphology and toxicity of A?1-42. Methods: We characterized the cell toxicity

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=cnr_________::4f54a44c71f739aa119ee166bab23c18
https://publications.cnr.it/doc/365611

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