Zobrazeno 1 - 10
of 43
pro vyhledávání: '"beta Catenin / metabolism"'
Autor:
Vincenzo Salemme, Mauro Vedelago, Alessandro Sarcinella, Federico Moietta, Alessio Piccolantonio, Enrico Moiso, Giorgia Centonze, Marta Manco, Andrea Guala, Alessia Lamolinara, Costanza Angelini, Alessandro Morellato, Dora Natalini, Raffaele Calogero, Danny Incarnato, Salvatore Oliviero, Laura Conti, Manuela Iezzi, Daniela Tosoni, Giovanni Bertalot, Stefano Freddi, Francesco A. Tucci, Francesco De Sanctis, Cristina Frusteri, Stefano Ugel, Vincenzo Bronte, Federica Cavallo, Paolo Provero, Marta Gai, Daniela Taverna, Emilia Turco, Salvatore Pece, Paola Defilippi
Publikováno v:
Nature Communications, 14(1):2350. Nature Publishing Group
The p140Cap adaptor protein is a tumor suppressor in breast cancer associated with a favorable prognosis. Here we highlight a function of p140Cap in orchestrating local and systemic tumor-extrinsic events that eventually result in inhibition of the p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2954a3b0484f1a7c6d65cdc019fb61bb
https://doi.org/10.1038/s41467-023-37824-y
https://doi.org/10.1038/s41467-023-37824-y
Autor:
Ida Sola, Valentina Karin‑Kujundzic, Frane Paic, Lada Lijovic, Mislav Glibo, Nikola Serman, Tihana Duic, Anita Skrtic, Krunoslav Kuna, Semir Vranic, Ljiljana Serman
Placental insufficiency is a common cause of intrauterine growth restriction (IUGR). It affects ~10% of pregnancies and increases fetal and neonatal morbidity and mortality. Although Wnt and Hh pathways are crucial for embryonic development and place
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::198042dc83dc8282d4c80692ceb07f04
https://doi.org/10.3892/mmr.2022.12914
https://doi.org/10.3892/mmr.2022.12914
Publikováno v:
Annual review of biochemistry. 91
The Wnt pathway is central to a host of developmental and disease-related processes. The remarkable conservation of this intercellular signaling cascade throughout metazoan lineages indicates that it coevolved with multicellularity to regulate the ge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4107c0f755b6d5296b6872840ac075d3
https://pubmed.ncbi.nlm.nih.gov/35303793
https://pubmed.ncbi.nlm.nih.gov/35303793
Autor:
Arpan Parichha, Varun Suresh, Mallika Chatterjee, Aditya Kshirsagar, Lihi Ben-Reuven, Tsviya Olender, M. Mark Taketo, Velena Radosevic, Mihaela Bobic-Rasonja, Sara Trnski, Michael J. Holtzman, Nataša Jovanov-Milosevic, Orly Reiner, Shubha Tole
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-20 (2022)
The choroid plexus secretes cerebrospinal fluid and is critical for the development and function of the brain. In the telencephalon, the choroid plexus epithelium arises from the Wnt- expressing cortical hem. Canonical Wnt signaling pathway molecules
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78188af730de0afd2ce5c5adc776ba8f
https://doi.org/10.1038/s41467-021-27602-z
https://doi.org/10.1038/s41467-021-27602-z
Autor:
Christine Sempoux, Massimo Bongiovanni, Nicolas Demartines, Vanessa Schneider, Stefano La Rosa, Edoardo Missiaglia, Gian Dorta, Bettina Bisig, Chiara Saglietti
Publikováno v:
Virchows Archiv, vol. 475, no. 6, pp. 789-794
Acinar cell carcinomas (ACCs) of the pancreas are a heterogeneous group of neoplasms showing a wide spectrum of morphological features including acinar, solid, glandular, and trabecular architecture. In addition, uncommon cytological aspects have rec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::695ffe4f15a2e02d8c7ffefe115f4cbe
https://doi.org/10.1007/s00428-019-02628-3
https://doi.org/10.1007/s00428-019-02628-3
Autor:
Cezanne Miete, Gonzalo P. Solis, Alexey Koval, Martina Brückner, Vladimir L. Katanaev, Jürgen Behrens, Dominic B. Bernkopf
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Nature communications, Vol. 13, No 1 (2022) P. 674
Nature communications, Vol. 13, No 1 (2022) P. 674
Conductin/axin2 is a scaffold protein negatively regulating the pro-proliferative Wnt/β-catenin signaling pathway. Accumulation of scaffold proteins in condensates frequently increases their activity, but whether condensation contributes to Wnt path
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe885a2c8672e90aca452bf1e54608d6
https://pubmed.ncbi.nlm.nih.gov/35115535
https://pubmed.ncbi.nlm.nih.gov/35115535
Autor:
Kang Yell Choi, Jong Chan Park, Jeong Su Yoon, Yong Hee Cho, Dong Woo Kang, Eun Ji Ro, Hans Clevers, Tae Il Kim, Tomohiro Mizutani
Publikováno v:
Nature Communications, 11(1). Nature Publishing Group
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Nature Communications
5-Fluorouracil (5-FU) remains the first-line treatment for colorectal cancer (CRC). Although 5-FU initially de-bulks the tumor mass, recurrence after chemotherapy is the barrier to effective clinical outcomes for CRC patients. Here, we demonstrate th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5c3cd05c8716e3e7fd22f0717726d0f
https://hdl.handle.net/20.500.11755/de483e27-9a68-49de-bf37-80bb92ac9c00
https://hdl.handle.net/20.500.11755/de483e27-9a68-49de-bf37-80bb92ac9c00
Autor:
Silvia Corrochano, Abigail Harris, Hans Clevers, Caroline Eozenou, Isabelle Stévant, Joelle Bignon-Topalovic, Nick Warr, Neila Belguith, Sara Wells, Bochra Ben Rhouma, Pam Siggers, Serge Nef, Daniel T. Grimes, Ken McElreavey, Rebecca D. Burdine, Feng Cong, Makoto Suzuki, Andy Greenfield, Danielle Sagar, Anu Bashamboo, Bon-Kyoung Koo, Raja Brauner
Publikováno v:
Proceedings of the National Academy of Sciences, Vol. 115, No 21 (2018) pp. 5474-5479
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, 2018, 115 (21), pp.5474-5479. ⟨10.1073/pnas.1801223115⟩
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2018, 115 (21), pp.5474-5479. ⟨10.1073/pnas.1801223115⟩
Proceedings of the National Academy of Sciences of the United States of America, 115(21), 5474
Proceedings of the National Academy of Sciences of the United States of America, 115(21), 5474-5479. National Academy of Sciences
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, 2018, 115 (21), pp.5474-5479. ⟨10.1073/pnas.1801223115⟩
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2018, 115 (21), pp.5474-5479. ⟨10.1073/pnas.1801223115⟩
Proceedings of the National Academy of Sciences of the United States of America, 115(21), 5474
Proceedings of the National Academy of Sciences of the United States of America, 115(21), 5474-5479. National Academy of Sciences
International audience; Mammalian sex determination is controlled by the antagonistic interactions of two genetic pathways: The SRY-SOX9-FGF9 network promotes testis determination partly by opposing proovarian pathways, while RSPO1/WNT-β-catenin/FOX
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f785b7c346bbb98027161ca7382405e7
https://hdl.handle.net/20.500.11755/a85a814a-a5a7-4064-9ca8-516f15a8bb58
https://hdl.handle.net/20.500.11755/a85a814a-a5a7-4064-9ca8-516f15a8bb58
Autor:
Anja Kafka, Anja Bukovac, Darko Orešković, Katarina Dragičević, Sanja Cesarec-Augustinović, Nives Pećina-Šlaus
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 11996, p 11996 (2021)
International Journal of Molecular Sciences, Vol 22, Iss 11996, p 11996 (2021)
In the search for molecular candidates for targeted meningioma therapies, increasing attention has been paid to the role of signaling pathways in the development and progression of intracranial meningiomas. Although it is well known that the Wnt sign
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02ec410a5b0c83459cf7f7e05af24669
https://doi.org/10.3390/ijms222111996
https://doi.org/10.3390/ijms222111996
Autor:
Etienne Meylan, Anne-Laure Rougemont, Pierre-Benoit Ancey, Mauro Delorenzi, Catherine Guettier, Jessica Vazquez, Vincent Zoete, Stefania Crippa, Olivier Michielin, Paolo Angelino
Publikováno v:
EMBO Molecular Medicine, Vol. 9, No 11 (2017) pp. 1589-1604
EMBO molecular medicine, vol. 9, no. 11, pp. 1589-1604
EMBO Molecular Medicine
EMBO molecular medicine, vol. 9, no. 11, pp. 1589-1604
EMBO Molecular Medicine
Hepatoblastoma is the most common malignant pediatric liver cancer. Histological evaluation of tumor biopsies is used to distinguish among the different subtypes of hepatoblastoma, with fetal and embryonal representing the two main epithelial compone
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c492244964b91e0f36752bc02c8ac9ce
https://doi.org/10.15252/emmm.201707814
https://doi.org/10.15252/emmm.201707814