Zobrazeno 1 - 10
of 2 618
pro vyhledávání: '"bcrp"'
Publikováno v:
Current Issues in Molecular Biology, Vol 46, Iss 9, Pp 9686-9706 (2024)
The aim of this review is to explore how diet and dietary supplements influence the activity of key multidrug resistance (MDR) transporters—MRP2, BCRP, and P-gp. These transporters play a crucial role in drug efflux from cancer cells and significan
Externí odkaz:
https://doaj.org/article/dd123db7cd224c3a8ec49aa06de61f08
Publikováno v:
Journal of Applied Poultry Research, Vol 33, Iss 3, Pp 100439- (2024)
SUMMARY: The administration of drugs via the oral route is challenging due to the presence of physiologic barrier. BCRP, which can actively transport substrates from intra- to extracellular environment, has an important functional role in the composi
Externí odkaz:
https://doaj.org/article/e87673548c574e53b0e27f999cd03177
Autor:
Lydia Kuhnert, Robert Kuhnert, Menyhárt B. Sárosi, Cathleen Lakoma, Birte K. Scholz, Peter Lönnecke, Evamarie Hey‐Hawkins, Walther Honscha
Publikováno v:
Molecular Oncology, Vol 18, Iss 2, Pp 280-290 (2024)
Success of chemotherapy is often hampered by multidrug resistance. One mechanism for drug resistance is the elimination of anticancer drugs through drug transporters, such as breast cancer resistance protein (BCRP; also known as ABCG2), and causes a
Externí odkaz:
https://doaj.org/article/e96a44f6f69c429da99bfd278b0a0705
Autor:
Xuan-Yu Chen, Zhuo-Xun Wu, Jing-Quan Wang, Qiu-Xu Teng, Hailin Tang, Qianwen Liu, Zhe-Sheng Chen, Wenkuan Chen
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
The therapeutic effect of chemotherapy and targeted therapy are known to be limited by drug resistance. Substantial evidence has shown that ATP-binding cassette (ABC) transporters P-gp and BCRP are significant contributors to multidrug resistance (MD
Externí odkaz:
https://doaj.org/article/5b33008691864d0b841b93d90e0769ec
Autor:
Agnieszka Jeleń, Marta Żebrowska-Nawrocka, Mariusz Łochowski, Dagmara Szmajda-Krygier, Ewa Balcerczak
Publikováno v:
Biomedicines, Vol 12, Iss 10, p 2394 (2024)
Background/Objectives: ATP-binding cassette subfamily G member 2 [ABCG2/breast cancer resistance protein (BCRP)] contributes to mechanisms of multidrug resistance (MDR) and is a marker of side population (SP) cells in human cancers. The primary objec
Externí odkaz:
https://doaj.org/article/173f2944d80e42e6888f478abcf261ec
Autor:
Pollinzi, Angela 1, Mirdamadi, Kamelia 1, Karimian-Pour, Navaz 1, Asthana-Nijjar, Rashi 1, Lee, Dennis 2, Nevo, Ori 2, Piquette-Miller, Micheline 1, ∗
Publikováno v:
In Drug Metabolism and Disposition November 2024
Autor:
Yu. S. Tranova, A. A. Slepnev, I. V. Chernykh, A. V. Shchulkin, P. Yu. Mylnikov, N. M. Popova, M. I. Povetko, E. N. Yakusheva
Publikováno v:
Разработка и регистрация лекарственных средств, Vol 12, Iss 2, Pp 87-94 (2023)
Introduction. Breast cancer resistance protein (BCRP) is an efflux membrane transporter that controls the pharmacokinetics of a large number of drugs. Its activity may change when taking some endo- and exogenous substances, thus making it a link in d
Externí odkaz:
https://doaj.org/article/a0fc4f5e332d4ee2a902ab9c13753670
Publikováno v:
Pharmaceutics, Vol 16, Iss 8, p 992 (2024)
Of the 450 cell membrane transporters responsible for shuttling substrates, nutrients, hormones, neurotransmitters, antioxidants, and signaling molecules, approximately nine are associated with clinically relevant drug–drug interactions (DDIs) due
Externí odkaz:
https://doaj.org/article/e673aa70b048492ea899e5b6e6643a58
Autor:
Emőke Sóskuti, Nóra Szilvásy, Csilla Temesszentandrási-Ambrus, Zoltán Urbán, Olivér Csíkvári, Zoltán Szabó, Gábor Kecskeméti, Éva Pusztai, Zsuzsanna Gáborik
Publikováno v:
Pharmaceutics, Vol 16, Iss 6, p 736 (2024)
Implementing the 3R initiative to reduce animal experiments in brain penetration prediction for CNS-targeting drugs requires more predictive in vitro and in silico models. However, animal studies are still indispensable to obtaining brain concentrati
Externí odkaz:
https://doaj.org/article/a94321fbe560458d94a6ee7221ab5362
Autor:
Chetan P. Kulkarni, Jia Yang, Megan L. Koleske, Giovanni Lara, Khondoker Alam, Andre Raw, Bhagwant Rege, Liang Zhao, Dongmei Lu, Lei Zhang, Lawrence X. Yu, Robert A. Lionberger, Kathleen M. Giacomini, Deanna L. Kroetz, Sook Wah Yee
Publikováno v:
Pharmaceutics, Vol 16, Iss 5, p 647 (2024)
The presence of mutagenic and carcinogenic N-nitrosamine impurities in medicinal products poses a safety risk. While incorporating antioxidants in formulations is a potential mitigation strategy, concerns arise regarding their interference with drug
Externí odkaz:
https://doaj.org/article/db2f7b3198274994a190b6df5cb02c07