Zobrazeno 1 - 10
of 135
pro vyhledávání: '"bavituximab"'
Publikováno v:
ImmunoTargets and Therapy, Vol Volume 7, Pp 1-14 (2018)
Olivier Belzile,1 Xianming Huang,2,3 Jian Gong,2,3 Jay Carlson,2,3 Alan J Schroit,1 Rolf A Brekken,1 Bruce D Freimark2,3 1Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, TX, 2Department of Prec
Externí odkaz:
https://doaj.org/article/10115c296747468f8bde43a189d276b3
Autor:
Knez, Barbara
Fosfatidilserin (PS) je esencialni membranski fosfolipid, ki ga najdemo v vseh domenah življenja. Sodeluje v številnih bioloških procesih, pri čemer pa je najbolj pomembna njegova lokacija. V zdravih celicah se PS nahaja izključno na notranji st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______3505::ab964ff84e29f5adf1b43bfe6a0ecb7f
https://repozitorij.uni-lj.si/IzpisGradiva.php?id=139033
https://repozitorij.uni-lj.si/IzpisGradiva.php?id=139033
Publikováno v:
Theranostics
Cancer is a leading cause of mortality and morbidity worldwide. Despite major improvements in current therapeutic methods, ideal therapeutic strategies for improved tumor elimination are still lacking. Recently, immunotherapy has attracted much atten
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6749511f79e9b4ad3d3f88b770a32518
https://pubmed.ncbi.nlm.nih.gov/32802188
https://pubmed.ncbi.nlm.nih.gov/32802188
Autor:
Olivier Belzile, Bruce Freimark, Jian Gong, Jay Carlson, Alan J. Schroit, Rolf A. Brekken, Xianming Huang
Publikováno v:
ImmunoTargets and Therapy
Phosphatidylserine (PS) is a negatively charged phospholipid in all eukaryotic cells that is actively sequestered to the inner leaflet of the cell membrane. Exposure of PS on apoptotic cells is a normal physiological process that triggers their rapid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a544ee181beb80ec67bb021eb25189ef
https://doi.org/10.2147/itt.s134834
https://doi.org/10.2147/itt.s134834
Autor:
Jonathan E. Dowell, Ali A. Mokdad, Adam C. Yopp, Amit G. Singal, Hao Zhu, Muhammad Shaalan Beg, Yull Edwin Arriaga
Publikováno v:
Targeted Oncology. 14:541-550
Bavituximab, an immunomodulator, targets phosphatidylserine (PS), a membrane lipid externalized on tumor and endothelial cells in response to sorafenib.The objective of this phase II study was to assess the efficacy of combination bavituximab and sor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3f538a90e795901d97d9185e3a64bd1
https://doi.org/10.1007/s11523-019-00663-3
https://doi.org/10.1007/s11523-019-00663-3
Autor:
Haeseong Park, J.W. Lee, S. Gopal, V. Chamberlain Santos, L. Benjamin, Marya F. Chaney, I. Chau, H. Youssoufian, C. Mockbee, S. MacIntyre, Daniel Virgil Thomas Catenacci, Johanna C. Bendell, K. Culm-Merdek
Publikováno v:
Annals of Oncology. 32:S1050-S1051
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::92d6d3a90272b92e65c07b36213f6785
https://doi.org/10.1016/j.annonc.2021.08.1495
https://doi.org/10.1016/j.annonc.2021.08.1495
Publikováno v:
Annals of Oncology. 32:S822-S823
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::df388562a45402cb8168c9ed62c5d545
https://doi.org/10.1016/j.annonc.2021.08.159
https://doi.org/10.1016/j.annonc.2021.08.159
Autor:
Rolf A. Brekken, Sukhwinder Singh, Abraham Pinter, William J. Honnen, Maria Laura Gennaro, Raymond B. Birge, Varsha Gadiyar, Tamara Kreiss, Sergei V. Kotenko, Kevin C. Lahey, Viralkumar Davra, David S. Ucker, Dabbu Kumar Jaijyan, Charles Reichman, John J. Siekierka, Canan Kasikara, Alok Choudhary, David Calianese, Ke Geng
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 207(2)
Phosphatidylserine (PS)-targeting monoclonal Abs (mAbs) that directly target PS and target PS via β2-gp1 (β2GP1) have been in preclinical and clinical development for over 10 y for the treatment of infectious diseases and cancer. Although the inten
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::668e8109c500870a26b6d4f2f7506044
https://pubmed.ncbi.nlm.nih.gov/34215655
https://pubmed.ncbi.nlm.nih.gov/34215655
Autor:
Sun, Amy, Benet, Leslie Z
Publikováno v:
Pharmacology, vol 105, iss 3-4
AimTo analyze the late-stage failures of monoclonal antibody drugs. The later a drug fails in development, the more time and expense is incurred by the sponsor.MethodsWe review the late stage, Phase III, failures of 21 monoclonal antibody drugs betwe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::2d99e776bbea6081be4bdab56e32ae4d
https://escholarship.org/uc/item/76s2b1vp
https://escholarship.org/uc/item/76s2b1vp
Autor:
Bhupender Sharma, Shamsher S. Kanwar
Publikováno v:
Seminars in Cancer Biology. 52:17-25
Cancer is a leading cause of mortality and morbidity globally. Many prominent cancer-associated molecules have been identified over the recent years which include EGFR, CD44, TGFbRII, HER2, miR-497, NMP22, BTA, Fibrin/FDP etc. These biomarkers are of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37c007a6b654e08f18e80f94f3fdd98b
https://doi.org/10.1016/j.semcancer.2017.08.012
https://doi.org/10.1016/j.semcancer.2017.08.012