A broadly cross-reactive monoclonal antibody against hepatitis E virus capsid antigen

Autor: Paulius Lukas Tamosiunas, Martin H. Groschup, Kornelija Markuškienė, Marc Hovestädt, Frank Sellrie, Johannes Scholz, Laima Cepulyte, Henry Memczak, Franziska Ramm, Victor M. Corman, Rasa Petraityte-Burneikiene, Jochen Reetz, D. Becher, Jörg A. Schenk, René Ryll, Paul Dremsek, Stefan Kubick, Anika Andersson, Rainer G. Ulrich, Reimar Johne, Hoai Anh Trinh, Barbara Kubickova

Publikováno v: Applied microbiology and biotechnology, New York : Springer, 2021, vol. 105, iss. 12, p. 4957-4973
Applied Microbiology and Biotechnology

Abstract To generate a hepatitis E virus (HEV) genotype 3 (HEV-3)–specific monoclonal antibody (mAb), the Escherichia coli–expressed carboxy-terminal part of its capsid protein was used to immunise BALB/c mice. The immunisation resulted in the in

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