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pro vyhledávání: '"basket trial"'
Basket trials can efficiently evaluate a single treatment across multiple diseases with a common shared target. Prior methods for randomized basket trials required baskets to have the same sample and effect sizes. To that end, we developed a general
Externí odkaz:
http://arxiv.org/abs/2411.13692
Autor:
Schmitt, Sabrina, Baumann, Lukas
Basket trials examine the efficacy of an intervention in multiple patient subgroups simultaneously. The division into subgroups, called baskets, is based on matching medical characteristics, which may result in small sample sizes within baskets that
Externí odkaz:
http://arxiv.org/abs/2409.10318
Optimizing doses for multiple indications is challenging. The pooled approach of finding a single optimal biological dose (OBD) for all indications ignores that dose-response or dose-toxicity curves may differ between indications, resulting in varyin
Externí odkaz:
http://arxiv.org/abs/2408.15502
Basket trials test a single therapeutic treatment on several patient populations under one master protocol. A desirable adaptive design feature in these studies may be the incorporation of new baskets to an ongoing study. Limited basket sample sizes
Externí odkaz:
http://arxiv.org/abs/2407.06069
Autor:
Baumann, Lukas1 (AUTHOR) baumann@imbi.uni-heidelberg.de, Sauer, Lukas D.1 (AUTHOR), Kieser, Meinhard1 (AUTHOR)
Publikováno v:
Statistics in Biopharmaceutical Research. Sep2024, p1-11. 11p. 2 Illustrations.
Basket trial designs are a type of master protocol in which the same therapy is tested in several strata of the patient cohort. Many basket trial designs implement borrowing mechanisms. These allow sharing information between similar strata with the
Externí odkaz:
http://arxiv.org/abs/2403.02058
Publikováno v:
Statistics in Biopharmaceutical Research. Apr-Jun2024, Vol. 16 Issue 2, p229-240. 12p.
Autor:
Baumann, Lukas
Basket trials are a new type of clinical trial in which a treatment is investigated in several subgroups. For the analysis of these trials, information is shared between the subgroups based on the observed data to increase the power. Many approaches
Externí odkaz:
http://arxiv.org/abs/2403.17510
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