Zobrazeno 1 - 10
of 416
pro vyhledávání: '"base excision repair (BER)"'
Autor:
María Castejón-Griñán, Sonia Cerdido, José Sánchez-Beltrán, Ana Lambertos, Marta Abrisqueta, Cecilia Herraiz, Celia Jiménez-Cervantes, José Carlos García-Borrón
Publikováno v:
Redox Biology, Vol 72, Iss , Pp 103135- (2024)
Cutaneous melanoma, a lethal skin cancer, arises from malignant transformation of melanocytes. Solar ultraviolet radiation (UVR) is a major environmental risk factor for melanoma since its interaction with the skin generates DNA damage, either direct
Externí odkaz:
https://doaj.org/article/ba0a1e95cb73498d8a5a5f348a60c744
Autor:
Qingming Fang
Publikováno v:
Cancers, Vol 16, Iss 2, p 331 (2024)
O6-methylguanine-DNA methyltransferase (MGMT or AGT) is a DNA repair protein with the capability to remove alkyl groups from O6-AlkylG adducts. Moreover, MGMT plays a crucial role in repairing DNA damage induced by methylating agents like temozolomid
Externí odkaz:
https://doaj.org/article/3832a9f2bccd40d0880b3bba7207c5f9
Autor:
Dhia Azzouz, Nades Palaniyar
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Reactive oxygen species (ROS) is essential for neutrophil extracellular trap formation (NETosis), and generated either by NADPH oxidases (e.g., during infections) or mitochondria (e.g., sterile injury) in neutrophils. We recently showed that ultravio
Externí odkaz:
https://doaj.org/article/b4b1747eba5b483db5827d9c6092c851
Akademický článek
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Autor:
Xhaferr Tanushi, Guillaume Pinna, Marie Vandamme, Capucine Siberchicot, Ostiane D’Augustin, Anne-Marie Di Guilmi, J. Pablo Radicella, Bertrand Castaing, Rebecca Smith, Sebastien Huet, François Leteurtre, Anna Campalans
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
One of the most abundant DNA lesions induced by Reactive oxygen species (ROS) is 8-oxoG, a highly mutagenic lesion that compromises genetic instability when not efficiently repaired. 8-oxoG is specifically recognized by the DNA-glycosylase OGG1 that
Externí odkaz:
https://doaj.org/article/fb33b2e5d9f54efa87ae4201e6d9c02a
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Mitochondria are the primary sites for cellular energy production and are required for many essential cellular processes. Mitochondrial DNA (mtDNA) is a 16.6 kb circular DNA molecule that encodes only 13 gene products of the approximately 90 differen
Externí odkaz:
https://doaj.org/article/c88bfd5e0ecc4e4798daa6b421924502
Publikováno v:
Medičnì Perspektivi, Vol 27, Iss 1, Pp 4-9 (2022)
Heavy metals in model conditions as well as industrial pollution launch disturbances in neural cells of different animals and human beings. The neurotoxicity of mercury, which is one of the most toxic heavy metals, has been studied for several decade
Externí odkaz:
https://doaj.org/article/0645c937d0764066847326bcfd9dafad
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 18, p 14186 (2023)
Base excision repair (BER) corrects forms of oxidative, deamination, alkylation, and abasic single-base damage that appear to have minimal effects on the helix. Since its discovery in 1974, the field has grown in several facets: mechanisms, biology a
Externí odkaz:
https://doaj.org/article/a7574eda18f348268e8e4db465e2f367
Autor:
Dhia Azzouz, Nades Palaniyar
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Reactive oxygen species (ROS) is essential for neutrophil extracellular trap formation (NETosis). Nevertheless, how ROS induces NETosis at baseline and during neutrophil activation is unknown. Although neutrophils carry DNA transcription, replication
Externí odkaz:
https://doaj.org/article/87ded783422a47248915b59324558967
Autor:
Nidhi Sharma, Marlo K. Thompson, Jennifer F. Arrington, Dava M. Terry, Srinivas Chakravarthy, Peter E. Prevelige, Aishwarya Prakash
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
The maintenance of human mitochondrial DNA (mtDNA) is critical for proper cellular function as damage to mtDNA, if left unrepaired, can lead to a diverse array of pathologies. Of the pathways identified to participate in DNA repair within the mitocho
Externí odkaz:
https://doaj.org/article/1c42ca856e2647e582d990dc323a4999