Výsledky vyhledávání - "bacterial protein toxin"

Akademický článek

Combined Pharmacological Inhibition of Cyclophilins, FK506-Binding Proteins, Hsp90, and Hsp70 Protects Cells From Clostridium botulinum C2 Toxin

Autor: Katharina Ernst, Carolin Kling, Marc Landenberger, Holger Barth

Publikováno v: Frontiers in Pharmacology, Vol 9 (2018)

The Clostridium botulinum C2 toxin is an exotoxin causing severe enterotoxic symptoms. The C2 toxin consists of the binding/translocation component C2II, and the enzymatic active component C2I. After proteolytic activation, C2IIa forms heptamers that

Externí odkaz: https://doaj.org/article/47b554fcf2fc40b8b959bd79d1ac4cc6

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Akademický článek

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Akademický článek

Pasteurella multocida Toxin Activation of Heterotrimeric G Proteins by Deamidation

Autor: Orth, Joachim H. C., Preuss, Inga, Fester, Ines, Schlosser, Andreas, Wilson, Brenda A., Aktories, Klaus, Collier, R. John

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, 2009 Apr . 106(17), 7179-7184.

Externí odkaz: https://www.jstor.org/stable/40483394

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Akademický článek

The Modes of Action of MARTX Toxin Effector Domains

Autor: Byoung Sik Kim

Publikováno v: Toxins, Vol 10, Iss 12, p 507 (2018)

Many Gram-negative bacterial pathogens directly deliver numerous effector proteins from the bacterium to the host cell, thereby altering the target cell physiology. The already well-characterized effector delivery systems are type III, type IV, and t

Externí odkaz: https://doaj.org/article/0254195a971341c0adde95dca81e6c97

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Validated MALDI-TOF-MS method for anthrax lethal factor provides early diagnosis and evaluation of therapeutics

Autor: Alex R. Hoffmaster, Conrad P. Quinn, Adrian R. Woolfitt, Judy Brumlow, Gabriel T. Meister, Anne E. Boyer, Maribel Gallegos-Candela, John R. Barr, Renato C. Lins

Publikováno v: Analytical biochemistry

Anthrax lethal factor (LF) is a zinc-dependent endoprotease and a critical virulence factor for Bacillus anthracis, the causative agent of anthrax. The mass spectrometry (MS) method for total-LF quantification includes three steps; 1) LF specific ant

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::461c72bba79af7d4c0c622c2ce1a98ad
https://doi.org/10.1016/j.ab.2017.12.007

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Gut Microbiota and Colon Cancer: A Role for Bacterial Protein Toxins?

Autor: Zaira Maroccia, Elena Angela Pia Germinario, Alessia Fabbri, Sara Travaglione, Carla Fiorentini, Francesca Carlini

Publikováno v: International Journal of Molecular Sciences, Vol 21, Iss 6201, p 6201 (2020)
International Journal of Molecular Sciences

Accumulating evidence indicates that the human intestinal microbiota can contribute to the etiology of colorectal cancer. Triggering factors, including inflammation and bacterial infections, may favor the shift of the gut microbiota from a mutualisti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff6fe03563d32e890c84ae488747361f
https://doi.org/10.3390/ijms21176201

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Cyclophilin-Facilitated Membrane Translocation as Pharmacological Target to Prevent Intoxication of Mammalian Cells by Binary Clostridial Actin ADP-Ribosylated Toxins

Autor: Jens Michaelis, Simon Langer, Katharina Ernst, Eva Kaiser, Christian Osseforth, Miroslav Malesevic, Cordelia Schiene-Fischer, Viktoria Kahlert, Holger Barth, Carsten Schwan, Michel R. Popoff, Klaus Aktories

Publikováno v: Journal of Molecular Biology
Journal of Molecular Biology, Elsevier, 2015, 427 (6), pp.1224-1238. 〈10.1016/j.jmb.2014.07.013〉
Journal of Molecular Biology, Elsevier, 2015, 427 (6), pp.1224-1238. ⟨10.1016/j.jmb.2014.07.013⟩
Journal of Molecular Biology, 2015, 427 (6), pp.1224-1238. ⟨10.1016/j.jmb.2014.07.013⟩

International audience; Clostridium botulinum C2 toxin, Clostridium perfringens iota toxin and Clostridium difficile CDT belong to the family of binary actin ADP-ribosylating toxins and are composed of a binding/translocation component and a separate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::337f4383520a42318f8fc2bea83acfb8
https://doi.org/10.1016/j.jmb.2014.07.013

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ExoY, an actin-activated nucleotidyl cyclase toxin from P. aeruginosa: a minireview

Autor: Undine Mechold, Daniel Ladant, Alexander Belyy, Louis Renault

Publikováno v: Toxicon
Toxicon, Elsevier, 2017, ⟨10.1016/j.toxicon.2017.12.046⟩
Toxicon, 2017, ⟨10.1016/j.toxicon.2017.12.046⟩
Toxicon, Elsevier, 2017, 〈10.1016/j.toxicon.2017.12.046〉

International audience; ExoY is one of four well-characterized Pseudomonas aeruginosa type 3 secretion system (T3SS) effectors. It is a nucleotidyl cyclase toxin that is inactive inside the bacteria, but becomes potently activated once it is delivere

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8168d8240bd9671c562fb52febbb1e65
https://hal-pasteur.archives-ouvertes.fr/pasteur-01765203

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