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Autor:
Mathias B. Danielsen, Jesper Wengel
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 17, Iss 1, Pp 1828-1848 (2021)
Antisense oligonucleotides (ASOs) have the ability of binding to endogenous nucleic acid targets, thereby inhibiting the gene expression. Although ASOs have great potential in the treatment of many diseases, the search for favorable toxicity profiles
Externí odkaz:
https://doaj.org/article/1b7504243dad401e8ba68390a09d57d8
Autor:
Tarsila G. Castro, Manuel Melle-Franco, Cristina E. A. Sousa, Artur Cavaco-Paulo, João C. Marcos
Publikováno v:
Biomolecules, Vol 13, Iss 6, p 981 (2023)
This review provides a fresh overview of non-canonical amino acids and their applications in the design of peptidomimetics. Non-canonical amino acids appear widely distributed in nature and are known to enhance the stability of specific secondary str
Externí odkaz:
https://doaj.org/article/332b1706db364d5c98cacec22c789940
Autor:
Yeon Sun Lee
Publikováno v:
Biomolecules, Vol 12, Iss 9, p 1241 (2022)
Despite various advantages, opioid peptides have been limited in their therapeutic uses due to the main drawbacks in metabolic stability, blood-brain barrier permeability, and bioavailability. Therefore, extensive studies have focused on overcoming t
Externí odkaz:
https://doaj.org/article/1ab80e1aceb04f98a40958a963293296
Autor:
Santo Previti, Roberta Ettari, Carla Di Chio, Rahul Ravichandran, Marta Bogacz, Ute A. Hellmich, Tanja Schirmeister, Sandro Cosconati, Maria Zappalà
Publikováno v:
Molecules, Vol 27, Iss 12, p 3765 (2022)
Human African Trypanosomiasis (HAT) is an endemic protozoan disease widespread in the sub-Saharan region that is caused by T. b. gambiense and T. b. rhodesiense. The development of molecules targeting rhodesain, the main cysteine protease of T. b. rh
Externí odkaz:
https://doaj.org/article/5873f4bdecaa4d6e87e4e4cfc50782cc
Autor:
Melissa Meng, Christian Ducho
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 14, Iss 1, Pp 1293-1308 (2018)
Their unique ability to selectively bind specific nucleic acid sequences makes oligonucleotides promising bioactive agents. However, modifications of the nucleic acid structure are an essential prerequisite for their application in vivo or even in ce
Externí odkaz:
https://doaj.org/article/0e3b0ab0d1a24a0fbf21fd96e4aba461
Autor:
Castro, Tarsila Gabriel, Melle-Franco, Manuel, Sousa, Cristina E. A., Cavaco-Paulo, Artur, Marcos, João Carlos
This review provides a fresh overview of non-canonical amino acids and their applications in the design of peptidomimetics. Non-canonical amino acids appear widely distributed in nature and are known to enhance the stability of specific secondary str
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______307::711b5174082c4af04500dcfd9e83d8a9
https://hdl.handle.net/1822/84992
https://hdl.handle.net/1822/84992
Autor:
Dagmara Baraniak, Jerzy Boryski
Publikováno v:
Biomedicines, Vol 9, Iss 6, p 628 (2021)
This review covers studies which exploit triazole-modified nucleic acids in the range of chemistry and biology to medicine. The 1,2,3-triazole unit, which is obtained via click chemistry approach, shows valuable and unique properties. For example, it
Externí odkaz:
https://doaj.org/article/1d38c62abe6e445dbf0224e45fc34c37
Autor:
Jesper Wengel, Mathias B. Danielsen
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 17, Iss 1, Pp 1828-1848 (2021)
Danielsen, M B & Wengel, J 2021, ' Cationic oligonucleotide derivatives and conjugates : A favorable approach for enhanced DNA and RNA targeting oligonucleotides ', Beilstein Journal of Organic Chemistry, vol. 17, pp. 1828-1848 . https://doi.org/10.3762/bjoc.17.125
Beilstein Journal of Organic Chemistry
Danielsen, M B & Wengel, J 2021, ' Cationic oligonucleotide derivatives and conjugates : A favorable approach for enhanced DNA and RNA targeting oligonucleotides ', Beilstein Journal of Organic Chemistry, vol. 17, pp. 1828-1848 . https://doi.org/10.3762/bjoc.17.125
Beilstein Journal of Organic Chemistry
Antisense oligonucleotides (ASOs) have the ability of binding to endogenous nucleic acid targets, thereby inhibiting the gene expression. Although ASOs have great potential in the treatment of many diseases, the search for favorable toxicity profiles
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::505ce1f1d0bed89122f9bec96980b431
https://doaj.org/article/1b7504243dad401e8ba68390a09d57d8
https://doaj.org/article/1b7504243dad401e8ba68390a09d57d8
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 11, Iss 1, Pp 50-60 (2015)
Modifications of the nucleic acid backbone are essential for the development of oligonucleotide-derived bioactive agents. The NAA-modification represents a novel artificial internucleotide linkage which enables the site-specific introduction of posit
Externí odkaz:
https://doaj.org/article/fe88db2eea504042bbcf7c354d2bc4be