Sterol 14α-Demethylase Ligand-Binding Pocket-Mediated Acquired and Intrinsic Azole Resistance in Fungal Pathogens

Autor: Katharina Rosam, Brian C. Monk, Michaela Lackner

Publikováno v: Journal of Fungi, Vol 7, Iss 1, p 1 (2020)

The fungal cytochrome P450 enzyme sterol 14α-demethylase (SDM) is a key enzyme in the ergosterol biosynthesis pathway. The binding of azoles to the active site of SDM results in a depletion of ergosterol, the accumulation of toxic intermediates and

Externí odkaz: https://doaj.org/article/16428c8277c2480488d0ed485c34fcf7

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Sterol 14α-Demethylase Ligand-Binding Pocket-Mediated Acquired and Intrinsic Azole Resistance in Fungal Pathogens.

Autor: Rosam K; Institute of Hygiene and Medical Microbiology, Medical University of Innsbruck, Schöpfstrasse 41, 6020 Innsbruck, Austria., Monk BC; Sir John Walsh Research Institute and Department of Oral Biology, Faculty of Dentistry, University of Otago, PO Box 56, 9054 Dunedin, New Zealand., Lackner M; Institute of Hygiene and Medical Microbiology, Medical University of Innsbruck, Schöpfstrasse 41, 6020 Innsbruck, Austria.

Publikováno v: Journal of fungi (Basel, Switzerland) [J Fungi (Basel)] 2020 Dec 22; Vol. 7 (1). Date of Electronic Publication: 2020 Dec 22.