Structural and Mechanistic Regulation of the Pro-degenerative NAD Hydrolase SARM1

Autor: Matthew Bratkowski, Tian Xie, Desiree A. Thayer, Shradha Lad, Prakhyat Mathur, Yu-San Yang, Gregory Danko, Thomas C. Burdett, Jean Danao, Aaron Cantor, Jennifer A. Kozak, Sean P. Brown, Xiaochen Bai, Shilpa Sambashivan

Publikováno v: Cell Reports, Vol 32, Iss 5, Pp 107999- (2020)

Summary: The NADase SARM1 is a central switch in injury-activated axon degeneration, an early hallmark of many neurological diseases. Here, we present cryo-electron microscopy (cryo-EM) structures of autoinhibited (3.3 Å) and active SARM1 (6.8 Å) a

Externí odkaz: https://doaj.org/article/313bc7f0c8174c0b846a7e9facf8f63c

A common theme for axonopathies? The dependency cycle of local axon homeostasis

Autor: Andreas Prokop

Publikováno v: Prokop, A 2021, ' A common theme for axonopathies? The dependency cycle of local axon homeostasis ', Cytoskeleton, vol. 78, no. 2, pp. 52-63 . https://doi.org/10.1002/cm.21657

The number of acquired or inherited conditions leading to axon degeneration (from now on referred to as axonopathies) is vast. To diagnose patients, clinicians use a range of indicators including physiology, morphology, family and patient history, as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d84041f48923cdd4feca7d8632583c9d
https://pubmed.ncbi.nlm.nih.gov/33713552

Structural and Mechanistic Regulation of the Pro-degenerative NAD Hydrolase SARM1

Autor: Xiao Chen Bai, Desiree A. Thayer, Shilpa Sambashivan, Jean Danao, Tian Xie, Jennifer A. Kozak, Matthew Bratkowski, Prakhyat Mathur, Thomas C. Burdett, Sean P. Brown, Gregory Danko, Aaron Cantor, Shradha Lad, Yu San Yang

Publikováno v: Cell Reports, Vol 32, Iss 5, Pp 107999-(2020)

Summary The NADase SARM1 is a central switch in injury-activated axon degeneration, an early hallmark of many neurological diseases. Here, we present cryo-electron microscopy (cryo-EM) structures of autoinhibited (3.3 A) and active SARM1 (6.8 A) and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a8e618a4c2c183c475c8680f4f7ad46
https://doi.org/10.1016/j.celrep.2020.107999

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Lymphocytes with Cytotoxic Activity Induce Rapid Microtubule Axonal Destabilization Independently and before Signs of Neuronal Death

Autor: Vijaya L. Bodiga, Kalipada Pahan, Leah P. Shriver, Nichole M. Miller, Arundhati Jana, Avijit Ray, Bonnie N. Dittel, Rajiv Ahuja, Sreemanti Basu

Publikováno v: ASN Neuro, Vol 5 (2013)
ASN NEURO

MS (multiple sclerosis) is the most prevalent autoimmune disease of the CNS (central nervous system) historically characterized as an inflammatory and demyelinating disease. More recently, extensive neuronal pathology has lead to its classification a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e01b10e2b5c530bac4ee46646d510ad
https://doaj.org/article/958cf89618d0460ead83830f4ea5992b