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pro vyhledávání: '"axonal cytoskeleton"'
Akademický článek
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Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Neurons are highly polarized cells with elaborate shapes that allow them to perform their function. In neurons, microtubule organization—length, density, and dynamics—are essential for the establishment of polarity, growth, and transport. A mount
Externí odkaz:
https://doaj.org/article/f09102228feb460a963fb2d1446520b8
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 19, Iss , Pp 1738-1749 (2021)
Recent nanoscopy and super-resolution microscopy studies have substantiated the structural contribution of periodic actin-spectrin lattice to the axonal cytoskeleton of neuron. However, sufficient mechanical insight is not present for spectrin and ac
Externí odkaz:
https://doaj.org/article/37bb287457b64a41865e49f2ba301001
Autor:
Sushil Dubey, Nishita Bhembre, Shivani Bodas, Sukh Veer, Aurnab Ghose, Andrew Callan-Jones, Pramod Pullarkat
Publikováno v:
eLife, Vol 9 (2020)
Axons span extreme distances and are subject to significant stretch deformations during limb movements or sudden head movements, especially during impacts. Yet, axon biomechanics, and its relation to the ultrastructure that allows axons to withstand
Externí odkaz:
https://doaj.org/article/b652ca306b074abd9d6e31defbab2ef3
Autor:
Ana Rita Costa, Sara C Sousa, Rita Pinto-Costa, José C Mateus, Cátia DF Lopes, Ana Catarina Costa, David Rosa, Diana Machado, Luis Pajuelo, Xuewei Wang, Feng-quan Zhou, António J Pereira, Paula Sampaio, Boris Y Rubinstein, Inês Mendes Pinto, Marko Lampe, Paulo Aguiar, Monica M Sousa
Publikováno v:
eLife, Vol 9 (2020)
Neurons have a membrane periodic skeleton (MPS) composed of actin rings interconnected by spectrin. Here, combining chemical and genetic gain- and loss-of-function assays, we show that in rat hippocampal neurons the MPS is an actomyosin network that
Externí odkaz:
https://doaj.org/article/4602427c5eb7426abce176d9d2beeb7a
Autor:
Lobsiger, Christian S., Garcia, Michael L., Ward, Christopher M., Cleveland, Don W., Pollard, Thomas D.
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 2005 Jul . 102(29), 10351-10356.
Externí odkaz:
https://www.jstor.org/stable/3375979
Publikováno v:
Biomolecules, Vol 11, Iss 9, p 1308 (2021)
Microtubule-associated protein (MAP) tau is a cross-linking molecule that provides structural stability to axonal microtubules (MT). It is considered a potential biomarker for Alzheimer’s disease (AD), dementia, and other neurological disorders. It
Externí odkaz:
https://doaj.org/article/2e7ac2c45cef4b8a87ce174b066cc308
Autor:
Rishel Brenna Vohnoutka, Edward F. Boumil, Yuguan Liu, Atsuko Uchida, Harish C. Pant, Thomas B. Shea
Publikováno v:
Biology Open, Vol 6, Iss 10, Pp 1516-1527 (2017)
Phosphorylation of the C-terminal tail of the heavy neurofilament subunit (NF-H) impacts neurofilament (NF) axonal transport and residence within axons by fostering NF-NF associations that compete with transport. We tested the role of phosphorylation
Externí odkaz:
https://doaj.org/article/e0abb5973e3f4fbbbda52cbc17595979
Publikováno v:
Biomolecules, Vol 11, Iss 4, p 540 (2021)
Existent literature has limitations regarding the mechanical behavior of axonal cytoskeletal components in a high strain rate scenario, which is mainly due to limitations regarding the structure of some components such as tau protein and neurofilamen
Externí odkaz:
https://doaj.org/article/9294829af8044119b6893c3fef4dcd66
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 11 (2018)
In the adult nervous system axon caliber varies widely amongst different tracts. When considering a given axon, its diameter can further fluctuate in space and time, according to processes including the distribution of organelles and activity-depende
Externí odkaz:
https://doaj.org/article/e23a32d2a5484d09987b8e637ded29cf